| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man 2 | - | - | - | $1,786,511 | 95 | $1,903,726 | Apr 30 | United International Pictures | false |
| 2 | Clash of the Titans | - | - | - | $1,185,599 | 93 | $3,010,415 | Apr 16 | Warner Bros. | false |
| 3 | A Nightmare on Elm Street | - | - | - | $1,142,051 | 55 | $1,672,304 | May 14 | Warner Bros. | false |
| 4 | Legion | - | - | - | $560,163 | 41 | $610,696 | May 7 | Sony Pictures Releasing | false |
| 5 | Date Night | - | - | - | $482,643 | 61 | $1,299,140 | Apr 9 | 20th Century Fox International | false |
| 6 | Nanny McPhee Returns | - | - | - | $413,207 | 37 | $636,120 | May 14 | United International Pictures | false |
| 7 | The Back-up Plan | - | - | - | $333,243 | 40 | $730,413 | May 21 | Sony Pictures Releasing | false |
| 8 | Toy Story 2009 Re-release | - | - | - | $255,035 | 8 | $255,035 | May 14 | Walt Disney Pictures | false |
| 9 | Paranormal Activity | - | - | - | $229,401 | 38 | $349,537 | Apr 23 | - | false |
| 10 | Marmaduke | - | - | - | $201,269 | 54 | $1,110,195 | May 28 | 20th Century Fox International | false |
| 11 | How to Train Your Dragon | - | - | - | $172,568 | 76 | $1,719,199 | Mar 26 | United International Pictures | false |
| 12 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $154,840 | 23 | $161,603 | May 7 | - | false |
| 13 | Cop Out | - | - | - | $123,992 | 43 | $458,560 | May 28 | Warner Bros. | false |
| 14 | SubHysteria | - | - | - | $96,438 | 15 | $213,015 | May 14 | - | false |
| 15 | It's Complicated | - | - | - | $90,558 | 40 | $389,027 | May 28 | United International Pictures | false |
| 16 | Dear John | - | - | - | $88,834 | 15 | $141,889 | Apr 23 | Sony Pictures Releasing | false |
| 17 | Toy Story 2 2009 Re-release | - | - | - | $82,173 | 9 | $277,773 | May 28 | Walt Disney Pictures | false |
| 18 | Alice in Wonderland | - | - | - | $80,944 | 92 | $4,335,113 | Mar 5 | Walt Disney Pictures | false |
| 19 | I Hate Valentine's Day | - | - | - | $69,417 | 15 | $150,611 | Apr 16 | - | false |
| 20 | Case 39 | - | - | - | $56,156 | 29 | $265,440 | Apr 9 | United International Pictures | false |
| 21 | Everybody's Fine | - | - | - | $49,116 | 17 | $124,312 | Apr 9 | Walt Disney Pictures | false |
| 22 | Last Chance Harvey | - | - | - | $47,142 | 16 | $66,304 | May 21 | - | false |
| 23 | The Imaginarium of Doctor Parnassus | - | - | - | $46,660 | 10 | $113,890 | Apr 16 | Sony Pictures Releasing | false |
| 24 | The Bounty Hunter | - | - | - | $43,493 | 40 | $673,976 | Mar 31 | Sony Pictures Releasing | false |
| 25 | Did You Hear About the Morgans? | - | - | - | $41,235 | 40 | $253,991 | Apr 16 | Sony Pictures Releasing | false |
| 26 | A Prophet | - | - | - | $36,226 | 3 | $42,189 | Apr 30 | Sony Pictures Releasing | false |
| 27 | The Book of Eli | - | - | - | $17,950 | 63 | $996,734 | Mar 26 | Sony Pictures Releasing | false |
| 28 | Street Fighter: The Legend of Chun-Li | - | - | - | $17,209 | 14 | $40,802 | Apr 23 | - | false |
| 29 | The Haunting in Connecticut | - | - | - | $13,541 | 24 | $275,080 | Mar 26 | - | false |
| 30 | 500 Days of Summer | - | - | - | $10,389 | 7 | $97,037 | Mar 26 | 20th Century Fox International | false |
| 31 | The Return 2010 Re-release | - | - | - | $10,277 | 8 | $129,063 | Feb 26 | - | false |
| 32 | Feast 2010 Re-release | - | - | - | $4,704 | 4 | $30,281 | Mar 19 | - | false |
| 33 | Tarata | - | - | - | $4,291 | 3 | $4,291 | May 14 | - | false |
| 34 | Couples Retreat | - | - | - | $3,897 | 33 | $370,826 | Mar 26 | United International Pictures | false |
| 35 | Old Dogs | - | - | - | $582 | 51 | $2,468,108 | Feb 5 | United International Pictures | false |
