| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man 2 | - | - | - | $9,979,666 | 581 | $9,979,666 | Apr 30 | Paramount Pictures International | false |
| 2 | Robin Hood | - | - | - | $9,959,535 | 667 | $14,676,791 | May 12 | United International Pictures | false |
| 3 | Prince of Persia: The Sands of Time | - | - | - | $3,989,947 | 548 | $8,912,558 | May 19 | Walt Disney Pictures | false |
| 4 | OceanWorld | - | - | - | $3,260,746 | 266 | $3,297,162 | Apr 30 | Eagle Pictures | false |
| 5 | Weddings and Other Disasters | - | - | - | $2,733,144 | 305 | $4,769,415 | Apr 23 | 01 Distribution | false |
| 6 | The Final Destination | - | - | - | $2,710,678 | 338 | $4,590,236 | May 21 | Warner Bros. | false |
| 7 | Come Undone | - | - | - | $2,277,670 | 284 | $2,548,548 | Apr 30 | Warner Bros. | false |
| 8 | La nostra vita | - | - | - | $2,093,859 | 269 | $4,400,186 | May 21 | 01 Distribution | false |
| 9 | Sex and the City 2 | - | - | - | $2,072,658 | 476 | $7,802,889 | May 28 | Warner Bros. | false |
| 10 | Clash of the Titans | - | - | - | $1,874,842 | 533 | $10,275,464 | Apr 16 | Warner Bros. | false |
| 11 | Date Night | - | - | - | $1,815,224 | 222 | $1,815,224 | May 7 | 20th Century Fox International | false |
| 12 | Draquila - L'Italia che trema | - | - | - | $1,717,610 | 28 | $2,124,529 | May 7 | BIM Distribuzione | false |
| 13 | The Back-up Plan | - | - | - | $1,634,207 | 233 | $1,926,942 | May 14 | Sony Pictures Releasing | false |
| 14 | The Last Song | - | - | - | $1,589,637 | 247 | $1,589,637 | Apr 30 | Walt Disney Pictures | false |
| 15 | Furry Vengeance | - | - | - | $1,192,669 | 226 | $1,556,613 | May 7 | Eagle Pictures | false |
| 16 | Basilicata Coast to Coast | - | - | - | $946,416 | 196 | $4,588,816 | Apr 9 | Eagle Pictures | false |
| 17 | Dear John | - | - | - | $922,261 | 204 | $922,261 | May 7 | Sony Pictures Releasing | false |
| 18 | The Crazies | - | - | - | $567,815 | 283 | $1,499,039 | Apr 23 | Medusa Distribuzione | false |
| 19 | Wild Grass | - | - | - | $377,828 | 41 | $377,828 | Apr 30 | BIM Distribuzione | false |
| 20 | The Ghost Writer | - | - | - | $356,509 | 352 | $4,811,454 | Apr 9 | 01 Distribution | false |
| 21 | A Matador's Mistress | - | - | - | $350,810 | 101 | $350,810 | May 14 | Eagle Pictures | false |
| 22 | Shadow | - | - | - | $346,997 | - | $346,997 | May 14 | - | false |
| 23 | The Road | - | - | - | $330,222 | 151 | $1,630,241 | May 28 | - | false |
| 24 | The Girl Who Kicked the Hornet's Nest | - | - | - | $266,445 | 186 | $818,396 | May 28 | BIM Distribuzione | false |
| 25 | Departures | - | - | - | $243,506 | 42 | $868,327 | Apr 9 | - | false |
| 26 | Vengeance | - | - | - | $195,637 | 79 | $195,637 | Apr 30 | Fandango | false |
| 27 | Le ultime 56 ore | - | - | - | $190,483 | 184 | $190,483 | May 7 | Medusa Distribuzione | false |
| 28 | Certified Copy | - | - | - | $188,113 | 55 | $338,271 | May 21 | BIM Distribuzione | false |
| 29 | Green Zone | - | - | - | $182,017 | 301 | $3,636,987 | Apr 9 | Medusa Distribuzione | false |
| 30 | Loose Cannons | - | - | - | $179,097 | 427 | $10,994,715 | Mar 12 | 01 Distribution | false |
| 31 | La bella società | - | - | - | $170,072 | 147 | $170,072 | May 21 | Medusa Distribuzione | false |
| 32 | Una canzone per te | - | - | - | $163,109 | 205 | $413,920 | May 28 | United International Pictures | false |
| 33 | The Man Who Will Come | - | - | - | $134,641 | 69 | $1,877,452 | Jan 22 | Mikado Film | false |
| 34 | How to Train Your Dragon | - | - | - | $123,217 | 488 | $6,505,999 | Mar 26 | Universal Pictures International (UPI) | false |
| 35 | Happy Family | - | - | - | $119,808 | 353 | $6,111,219 | Mar 26 | 01 Distribution | false |
| 36 | Cell 211 | - | - | - | $78,370 | 173 | $773,108 | Apr 16 | - | false |
| 37 | Life Is a Wonderful Thing | - | - | - | $77,113 | 410 | $6,161,728 | Apr 2 | Medusa Distribuzione | false |
| 38 | From Paris with Love | - | - | - | $76,806 | 250 | $1,246,434 | Apr 16 | - | false |
| 39 | Life During Wartime | - | - | - | $74,496 | 10 | $209,587 | Apr 16 | - | false |
| 40 | The Bounty Hunter | - | - | - | $58,784 | 256 | $2,208,057 | Apr 9 | Sony Pictures Releasing | false |
| 41 | The First Beautiful Thing | - | - | - | $54,501 | 350 | $9,115,665 | Jan 15 | Medusa Distribuzione | false |
| 42 | The Concert | - | - | - | $54,114 | 139 | $4,825,505 | Feb 5 | BIM Distribuzione | false |
| 43 | No One Knows About Persian Cats | - | - | - | $54,042 | 38 | $217,434 | Apr 16 | BIM Distribuzione | false |
| 44 | Cirque du Freak: The Vampire's Assistant | - | - | - | $50,728 | 96 | $50,728 | May 7 | United International Pictures | false |
| 45 | Christine Cristina | - | - | - | $47,684 | 20 | $47,684 | May 7 | 01 Distribution | false |
| 46 | Little Girl | - | - | - | $44,602 | 11 | $92,103 | May 14 | - | false |
| 47 | The Last Station 2010 Re-release | - | - | - | $37,122 | 30 | $124,692 | May 28 | Sony Pictures Releasing | false |
| 48 | U2 3D | - | - | - | $31,434 | 31 | $182,003 | Apr 24 | Independent Films | false |
| 49 | Le Quattro Volte | - | - | - | $21,941 | 7 | $79,355 | May 28 | - | false |
| 50 | Fantastic Mr. Fox | - | - | - | $19,546 | 98 | $297,811 | Apr 16 | 20th Century Fox International | false |
| 51 | Alice in Wonderland | - | - | - | $15,858 | 668 | $39,952,697 | Mar 3 | Walt Disney Pictures | false |
| 52 | Call of the Wild | - | - | - | $15,800 | 62 | $206,094 | Feb 19 | - | false |
| 53 | Final Destination 3 | - | - | - | $13,177 | 272 | $2,767,155 | Mar 24 | Eagle Pictures | false |
| 54 | Little Nicholas | - | - | - | $11,436 | 159 | $935,187 | Apr 2 | BIM Distribuzione | false |
| 55 | A Prophet | - | - | - | $10,626 | 81 | $794,872 | Mar 19 | BIM Distribuzione | false |
| 56 | Avatar | - | - | - | $9,434 | 856 | $93,746,295 | Jan 15 | 20th Century Fox International | false |
| 57 | 14 kilómetros 2009 Re-release | - | - | - | $9,118 | 8 | $9,118 | May 28 | - | false |
| 58 | Simon Konianski | - | - | - | $8,874 | 25 | $150,872 | Apr 9 | Fandango | false |
| 59 | Invictus | - | - | - | $8,647 | 418 | $9,063,387 | Feb 26 | Warner Bros. | false |
| 60 | It's Complicated | - | - | - | $7,020 | 302 | $4,985,582 | Mar 19 | United International Pictures | false |
| 61 | Extraordinary Measures | - | - | - | $810 | 12 | $14,921 | Apr 23 | Sony Pictures Releasing | false |
