| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man 2 | - | - | - | $190,957 | 9 | $198,156 | Apr 30 | United International Pictures | false |
| 2 | Robin Hood | - | - | - | $95,179 | 8 | $157,766 | May 14 | United International Pictures | false |
| 3 | Prince of Persia: The Sands of Time | - | - | - | $62,680 | 9 | $146,755 | May 19 | Walt Disney Pictures | false |
| 4 | The Back-up Plan | - | - | - | $42,818 | 3 | $47,564 | May 5 | Sony Pictures Releasing | false |
| 5 | Kick-Ass | - | - | - | $40,712 | 5 | $135,879 | Apr 16 | - | false |
| 6 | Cop Out | - | - | - | $25,143 | 2 | $27,566 | May 5 | Warner Bros. | false |
| 7 | How to Train Your Dragon | - | - | - | $19,600 | 9 | $168,995 | Apr 2 | United International Pictures | false |
| 8 | She's Out of My League | - | - | - | $18,569 | 4 | $38,520 | Apr 23 | United International Pictures | false |
| 9 | Easy Money | - | - | - | $18,064 | 2 | $46,085 | May 19 | - | false |
| 10 | Date Night | - | - | - | $15,099 | 4 | $65,687 | Apr 9 | 20th Century Fox International | false |
| 11 | Astro Boy | - | - | - | $12,397 | 7 | $21,892 | Apr 23 | - | false |
| 12 | Crazy Heart | - | - | - | $8,447 | 1 | $20,680 | Apr 16 | 20th Century Fox International | false |
| 13 | Hot Tub Time Machine | - | - | - | $8,333 | 4 | $109,455 | Mar 31 | - | false |
| 14 | A Prophet | - | - | - | $7,977 | 1 | $7,977 | Apr 30 | Sony Pictures Releasing | false |
| 15 | I Love You Phillip Morris | - | - | - | $7,064 | 3 | $70,789 | Apr 2 | - | false |
| 16 | Brooklyn's Finest 2010 Re-release | - | - | - | $5,735 | 2 | $9,782 | May 19 | - | false |
| 17 | Clash of the Titans | - | - | - | $5,453 | 8 | $136,087 | Apr 9 | Warner Bros. | false |
| 18 | The Imaginarium of Doctor Parnassus | - | - | - | $5,272 | 1 | $8,331 | Apr 16 | - | false |
| 19 | The Spy Next Door 2010 Re-release | - | - | - | $5,007 | 3 | $15,768 | Apr 16 | - | false |
| 20 | The Girl Who Kicked the Hornet's Nest | - | - | - | $4,235 | 5 | $186,189 | Feb 19 | - | false |
| 21 | The Last Song | - | - | - | $4,055 | 3 | $19,568 | May 26 | Walt Disney Pictures | false |
| 22 | Nanny McPhee Returns | - | - | - | $4,014 | 4 | $29,775 | Mar 26 | United International Pictures | false |
| 23 | Amazon Jack 2010 Re-release | - | - | - | $3,674 | 4 | $17,935 | May 19 | - | false |
| 24 | Centurion | - | - | - | $3,168 | 2 | $12,041 | May 26 | - | false |
| 25 | Youth in Revolt | - | - | - | $2,762 | 2 | $11,802 | May 26 | - | false |
| 26 | The Crazies | - | - | - | $1,837 | 2 | $12,529 | Apr 16 | - | false |
| 27 | King's Road | - | - | - | $1,715 | 3 | $62,389 | Mar 26 | - | false |
| 28 | Oceans | - | - | - | $682 | 1 | $3,408 | May 26 | - | false |
| 29 | The Blind Side | - | - | - | $458 | 3 | $47,982 | Mar 12 | Warner Bros. | false |
| 30 | Dear John | - | - | - | $413 | 3 | $22,088 | Mar 31 | - | false |
