| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $10,456,017 | 646 | $28,769,165 | Apr 16 | Walt Disney Pictures | false |
| 2 | Robin Hood | - | - | - | $9,363,041 | 540 | $13,683,489 | May 13 | United International Pictures | false |
| 3 | Iron Man 2 | - | - | - | $7,318,444 | 547 | $7,601,695 | Apr 30 | Paramount Pictures International | false |
| 4 | Prince of Persia: The Sands of Time | - | - | - | $5,672,718 | 603 | $13,327,923 | May 21 | Walt Disney Pictures | false |
| 5 | To Hell with the Ugly | - | - | - | $5,225,121 | 296 | $9,246,548 | Apr 23 | Warner Bros. | false |
| 6 | Law Abiding Citizen | - | - | - | $3,507,846 | 301 | $4,678,297 | May 7 | Warner Bros. | false |
| 7 | The Back-up Plan | - | - | - | $2,345,634 | 370 | $2,482,690 | May 7 | Sony Pictures Releasing | false |
| 8 | Sorry, If I Love You | - | - | - | $1,461,439 | 177 | $1,440,866 | Apr 30 | - | false |
| 9 | Legion | - | - | - | $1,282,645 | 297 | $3,213,507 | May 28 | Sony Pictures Releasing | false |
| 10 | How to Train Your Dragon | - | - | - | $1,229,737 | 577 | $12,458,930 | Mar 26 | Paramount Pictures International | false |
| 11 | Date Night | - | - | - | $1,110,145 | 340 | $1,077,601 | May 7 | 20th Century Fox International | false |
| 12 | Two Lovers | - | - | - | $1,052,739 | 125 | $1,768,721 | May 14 | DeAPlaneta | false |
| 13 | Oceans | - | - | - | $997,714 | 123 | $1,638,607 | Apr 23 | Notro Films | false |
| 14 | The Ghost Writer | - | - | - | $921,481 | 289 | $7,125,447 | Mar 26 | Aurum Films | false |
| 15 | The Spy Next Door 2010 Re-release | - | - | - | $904,538 | 256 | $1,477,123 | Apr 23 | Aurum Films | false |
| 16 | Magic Journey to Africa | - | - | - | $883,301 | 181 | $1,070,844 | May 7 | Filmax | false |
| 17 | Clash of the Titans | - | - | - | $774,844 | 554 | $14,556,322 | Mar 31 | Warner Bros. | false |
| 18 | Room in Rome | - | - | - | $613,553 | 126 | $687,413 | May 7 | Paramount Pictures International | false |
| 19 | StreetDance 2 | - | - | - | $562,523 | 210 | $1,607,853 | May 28 | Aurum Films | false |
| 20 | The Time Traveler's Wife | - | - | - | $480,840 | 306 | $1,073,725 | Apr 23 | TriPictures | false |
| 21 | From Paris with Love | - | - | - | $428,654 | 282 | $1,854,791 | Apr 16 | Aurum Films | false |
| 22 | The Edge of Love | - | - | - | $412,141 | 102 | $387,006 | Apr 30 | DeAPlaneta | false |
| 23 | The Bounty Hunter | - | - | - | $368,283 | 344 | $4,053,717 | Apr 9 | Sony Pictures Releasing | false |
| 24 | Little Nicholas | - | - | - | $322,440 | 84 | $316,487 | May 7 | Vértigo Films | false |
| 25 | The Concert | - | - | - | $316,850 | 70 | $2,131,980 | Mar 12 | Vértigo Films | false |
| 26 | Hot Tub Time Machine | - | - | - | $307,556 | 240 | $744,973 | May 28 | DeAPlaneta | false |
| 27 | The Crazies | - | - | - | $284,668 | 203 | $827,739 | May 28 | - | false |
| 28 | Pièce montée | - | - | - | $282,700 | 82 | $482,037 | May 21 | - | false |
| 29 | Fish Tank | - | - | - | $268,501 | 35 | $282,878 | Apr 30 | Alta Films | false |
| 30 | Avatar | - | - | - | $230,705 | 800 | $107,309,094 | Dec 18 | 20th Century Fox International | false |
| 31 | Nanny McPhee Returns | - | - | - | $195,018 | 295 | $3,231,325 | Mar 31 | United International Pictures | false |
| 32 | I Am Love | - | - | - | $194,676 | 28 | $586,094 | May 21 | Alta Films | false |
| 33 | The Disciple | - | - | - | $189,092 | 53 | $219,297 | Apr 23 | - | false |
| 34 | Baaria | - | - | - | $184,886 | 55 | $272,207 | May 21 | TriPictures | false |
| 35 | Welcome | - | - | - | $141,175 | 32 | $139,030 | Apr 30 | Golem Distribución | false |
| 36 | Fashion Victim | - | - | - | $120,877 | 11 | $221,021 | May 14 | Alta Films | false |
| 37 | The Princess and the Frog | - | - | - | $114,748 | 400 | $11,594,881 | Feb 5 | Walt Disney Pictures | false |
| 38 | Night Runner | - | - | - | $112,443 | 92 | $519,911 | Mar 5 | Alta Films | false |
| 39 | E.S.O. Entitat sobrenatural oculta | - | - | - | $91,343 | 60 | $174,851 | Apr 23 | - | false |
| 40 | The Maid | - | - | - | $91,220 | 10 | $196,272 | Apr 16 | Golem Distribución | false |
| 41 | The Island Inside | - | - | - | $88,362 | 43 | $317,155 | Apr 9 | Alta Films | false |
| 42 | Shutter Island | - | - | - | $85,172 | 406 | $11,402,431 | Feb 19 | Manga Entertainment | false |
| 43 | Fantastic Mr. Fox | - | - | - | $75,240 | 30 | $136,634 | Apr 23 | 20th Century Fox International | false |
| 44 | City of Life and Death | - | - | - | $72,092 | 45 | $435,634 | Apr 9 | Karma Films | false |
| 45 | Dogtooth | - | - | - | $69,675 | 7 | $163,996 | May 14 | Karma Films | false |
| 46 | Siempre hay tiempo | - | - | - | $68,442 | 24 | $82,447 | May 14 | - | false |
| 47 | Soul Kitchen | - | - | - | $65,414 | 22 | $788,001 | Mar 31 | Golem Distribución | false |
| 48 | An Education | - | - | - | $64,213 | 61 | $1,308,337 | Feb 26 | Sony Pictures Releasing | false |
| 49 | Rage | - | - | - | $61,561 | 48 | $145,524 | May 28 | Wanda Visión S.A. | false |
| 50 | Remember Me | - | - | - | $60,095 | 249 | $45,781 | Mar 31 | Filmax | false |
| 51 | My Name Is Khan | - | - | - | $55,317 | 47 | $152,259 | May 28 | 20th Century Fox International | false |
| 52 | About Elly | - | - | - | $52,354 | 6 | $142,370 | May 21 | Golem Distribución | false |
| 53 | The Invention of Lying | - | - | - | $52,098 | 30 | $52,098 | Apr 30 | United International Pictures | false |
| 54 | The Hurt Locker | - | - | - | $44,059 | 136 | $3,930,210 | Jan 29 | DeAPlaneta | false |
| 55 | Crazy Loves | - | - | - | $42,515 | 34 | $533,412 | Feb 19 | Wanda Visión S.A. | false |
| 56 | Honeymoons | - | - | - | $36,533 | 7 | $35,744 | Apr 30 | Wanda Visión S.A. | false |
| 57 | Madre amadísima | - | - | - | $34,863 | 21 | $32,812 | May 7 | Karma Films | false |
| 58 | The Book of Eli | - | - | - | $33,983 | 304 | $5,069,500 | Mar 18 | Sony Pictures Releasing | false |
| 59 | Solstorm 2010 Re-release | - | - | - | $33,959 | 8 | $59,571 | May 21 | Karma Films | false |
| 60 | Ingrid | - | - | - | $33,509 | 34 | $31,782 | Apr 30 | - | false |
| 61 | Nausicaä of the Valley of the Wind 2010 Re-release | - | - | - | $31,215 | 4 | $39,306 | May 7 | Aurum Films | false |
| 62 | A Prophet | - | - | - | $30,367 | 58 | $567,672 | Feb 26 | Alta Films | false |
| 63 | No One Knows About Persian Cats | - | - | - | $29,913 | 28 | $130,513 | Apr 16 | Alta Films | false |
| 64 | For 80 Days | - | - | - | $28,931 | 14 | $115,251 | May 21 | Barton Films | false |
| 65 | The Widows of Thursdays | - | - | - | $20,280 | 85 | $518,952 | Mar 26 | Alta Films | false |
| 66 | Reykjavik-Rotterdam 2010 Re-release | - | - | - | $19,928 | 4 | $22,472 | May 14 | - | false |
| 67 | The White Ribbon | - | - | - | $19,733 | 45 | $2,226,344 | Jan 15 | Golem Distribución | false |
| 68 | The Girl Who Kicked the Hornet's Nest | - | - | - | $19,382 | 240 | $3,580,508 | Mar 5 | Vértigo Films | false |
| 69 | Paper Birds | - | - | - | $16,875 | 230 | $2,693,223 | Mar 12 | 20th Century Fox International | false |
| 70 | The Secret in Their Eyes | - | - | - | $16,502 | 18 | $8,220,014 | Sep 25 | Alta Films | false |
| 71 | Dear John | - | - | - | $14,658 | 210 | $2,590,323 | Mar 26 | Sony Pictures Releasing | false |
| 72 | Mentiras piadosas | - | - | - | $14,595 | 4 | $18,262 | Apr 23 | - | false |
| 73 | Tulpan | - | - | - | $12,951 | 6 | $56,543 | Apr 16 | Karma Films | false |
| 74 | Precious | - | - | - | $12,877 | 118 | $2,794,276 | Feb 5 | Filmax | false |
| 75 | Green Zone | - | - | - | $11,972 | 310 | $3,855,647 | Mar 12 | United International Pictures | false |
| 76 | The Marc Pease Experience | - | - | - | $11,685 | 33 | $11,397 | May 21 | - | false |
| 77 | Five Minutes of Heaven | - | - | - | $11,335 | 45 | $152,635 | Apr 9 | - | false |
| 78 | The Last Summer of La Boyita | - | - | - | $11,101 | 4 | $11,322 | May 7 | Warner Bros. | false |
| 79 | Unresolved Sexual Tension | - | - | - | $10,342 | 254 | $2,722,780 | Mar 18 | Paramount Pictures International | false |
| 80 | Desert Flower 2009 Re-release | - | - | - | $8,776 | 50 | $249,048 | Mar 12 | Golem Distribución | false |
| 81 | Fireflies in the Garden 2008 Re-release | - | - | - | $7,505 | 122 | $394,889 | Apr 2 | DeAPlaneta | false |
| 82 | The Day God Walked Away | - | - | - | $6,516 | 22 | $6,342 | Apr 30 | Barton Films | false |
| 83 | A Single Man | - | - | - | $6,220 | 99 | $870,400 | Feb 12 | Aurum Films | false |
| 84 | Cell 211 | - | - | - | $5,439 | 220 | $15,905,730 | Nov 6 | Paramount Pictures International | false |
| 85 | Post Grad | - | - | - | $4,555 | 30 | $25,226 | Apr 16 | 20th Century Fox International | false |
| 86 | The Boys Are Back | - | - | - | $4,470 | 147 | $288,286 | Apr 9 | DeAPlaneta | false |
| 87 | Garbo: The Spy | - | - | - | $3,841 | 18 | $319,279 | Dec 4 | - | false |
| 88 | La bomba del Liceu | - | - | - | $3,654 | 3 | $42,060 | Mar 12 | - | false |
| 89 | Ajami | - | - | - | $3,532 | 42 | $66,666 | Mar 26 | Karma Films | false |
| 90 | Lourdes | - | - | - | $3,420 | 27 | $82,474 | Mar 31 | Alta Films | false |
| 91 | The Trap 2010 Re-release | - | - | - | $3,383 | 2 | $6,933 | May 28 | - | false |
| 92 | Gentlemen Broncos | - | - | - | $3,114 | 30 | $3,114 | May 14 | 20th Century Fox International | false |
| 93 | Familystrip | - | - | - | $3,074 | 6 | $16,006 | May 28 | - | false |
| 94 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $2,330 | 424 | $5,879,303 | Feb 19 | 20th Century Fox International | false |
| 95 | The Hedgehog | - | - | - | $2,101 | 96 | $1,789,908 | Dec 11 | Alta Films | false |
| 96 | Up in the Air | - | - | - | $2,016 | 241 | $6,521,090 | Jan 22 | Paramount Pictures International | false |
| 97 | Son & Moon: diario de un astronauta | - | - | - | $1,645 | 4 | $1,645 | May 14 | - | false |
| 98 | For the Good of Others | - | - | - | $1,636 | 251 | $1,654,889 | Mar 18 | Alta Films | false |
| 99 | Stigmata | - | - | - | $1,586 | 2 | $1,586 | May 7 | - | false |
| 100 | Crazy Heart | - | - | - | $1,533 | 55 | $601,173 | Mar 5 | 20th Century Fox International | false |
| 101 | The Men Who Stare at Goats | - | - | - | $1,529 | 228 | $4,426,474 | Mar 5 | Sony Pictures Releasing | false |
| 102 | Brothers | - | - | - | $1,223 | 209 | $923,959 | Mar 18 | United International Pictures | false |
| 103 | Invictus | - | - | - | $1,031 | 303 | $10,313,309 | Jan 29 | Warner Bros. | false |
| 104 | Chéri | - | - | - | $721 | 84 | $561,150 | Jan 29 | Alta Films | false |
| 105 | Cloudy with a Chance of Meatballs | - | - | - | $584 | 491 | $7,000,967 | Dec 4 | Sony Pictures Releasing | false |
| 106 | Red Cliff | - | - | - | $429 | 187 | $851,418 | Mar 18 | TriPictures | false |
| 107 | Trouble at Timpetill | - | - | - | $222 | 50 | $252,647 | Mar 18 | - | false |
| 108 | Julie & Julia | - | - | - | $189 | 206 | $2,597,806 | Nov 6 | Sony Pictures Releasing | false |
| 109 | Born to Suffer | - | - | - | $59 | 86 | $537,825 | Feb 12 | Alta Films | false |
| 110 | Dragon Hunters | - | - | - | $58 | 99 | $464,848 | Mar 5 | - | false |
