| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man 2 | - | - | - | $1,211,345 | 53 | $1,243,781 | Apr 30 | United International Pictures | false |
| 2 | Clash of the Titans | - | - | - | $704,112 | 43 | $1,296,539 | Apr 23 | Importadora El Rosado | false |
| 3 | Prince of Persia: The Sands of Time | - | - | - | $336,481 | 48 | $1,231,250 | May 28 | Walt Disney Pictures | false |
| 4 | A Nightmare on Elm Street | - | - | - | $277,261 | 21 | $421,687 | May 21 | Importadora El Rosado | false |
| 5 | Garfield's Pet Force | - | - | - | $246,866 | 14 | $411,671 | May 21 | - | false |
| 6 | Legion | - | - | - | $188,720 | 25 | $191,464 | May 7 | Sony Pictures Releasing | false |
| 7 | The Bounty Hunter | - | - | - | $130,726 | 26 | $166,521 | May 21 | Sony Pictures Releasing | false |
| 8 | How to Train Your Dragon | - | - | - | $102,607 | 46 | $1,187,919 | Mar 26 | United International Pictures | false |
| 9 | The Last Song | - | - | - | $97,022 | 14 | $114,606 | May 14 | Walt Disney Pictures | false |
| 10 | The Rebound | - | - | - | $85,294 | 14 | $104,198 | May 13 | Importadora El Rosado | false |
| 11 | Case 39 | - | - | - | $63,681 | 16 | $92,708 | May 21 | United International Pictures | false |
| 12 | Remember Me | - | - | - | $63,449 | 13 | $68,947 | May 14 | - | false |
| 13 | 9 | - | - | - | $62,637 | 11 | $99,817 | Apr 23 | - | false |
| 14 | The Lovely Bones | - | - | - | $52,629 | 16 | $52,629 | May 7 | United International Pictures | false |
| 15 | Shutter Island | - | - | - | $23,719 | 16 | $139,720 | Apr 16 | United International Pictures | false |
| 16 | Date Night | - | - | - | $22,478 | 25 | $211,332 | Apr 9 | 20th Century Fox International | false |
| 17 | The Imaginarium of Doctor Parnassus | - | - | - | $22,114 | 7 | $35,677 | May 14 | Sony Pictures Releasing | false |
| 18 | Dear John | - | - | - | $22,012 | 25 | $121,068 | Apr 16 | Sony Pictures Releasing | false |
| 19 | Priceless 2009 Re-release | - | - | - | $21,503 | 4 | $26,220 | May 7 | - | false |
| 20 | The Blind Side | - | - | - | $21,489 | 13 | $140,998 | Mar 12 | Importadora El Rosado | false |
| 21 | When in Rome | - | - | - | $21,110 | 14 | $107,669 | Apr 16 | Walt Disney Pictures | false |
| 22 | The Hurt Locker | - | - | - | $18,895 | 4 | $60,008 | Apr 1 | - | false |
| 23 | Amelia | - | - | - | $9,505 | 6 | $9,505 | May 14 | 20th Century Fox International | false |
| 24 | Alice in Wonderland | - | - | - | $9,396 | 53 | $2,323,343 | Mar 5 | Walt Disney Pictures | false |
| 25 | The Soloist | - | - | - | $7,658 | 6 | $7,658 | May 14 | United International Pictures | false |
| 26 | The Wolfman | - | - | - | $4,679 | 30 | $323,146 | Apr 2 | United International Pictures | false |
| 27 | The Reader | - | - | - | $3,013 | 3 | $3,013 | May 7 | - | false |
| 28 | Everybody's Fine | - | - | - | $2,445 | 12 | $94,573 | Jan 29 | Walt Disney Pictures | false |
| 29 | Old Dogs | - | - | - | $1,844 | 28 | $637,344 | Feb 12 | Walt Disney Pictures | false |
| 30 | It's Complicated | - | - | - | $1,378 | 15 | $74,577 | Apr 9 | United International Pictures | false |
| 31 | [Rec]² | - | - | - | $840 | 7 | $84,022 | Apr 1 | - | false |
| 32 | An Education | - | - | - | $414 | 6 | $26,496 | Apr 9 | Sony Pictures Releasing | false |
| 33 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $118 | 31 | $570,938 | Feb 12 | 20th Century Fox International | false |
