| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Alice in Wonderland | - | - | - | $2,565,969 | 125 | $3,140,515 | May 13 | Walt Disney Pictures | false |
| 2 | Iron Man 2 | - | - | - | $1,455,515 | 96 | $1,454,137 | Apr 29 | United International Pictures | false |
| 3 | A Nightmare on Elm Street | - | - | - | $606,620 | 43 | $926,392 | May 20 | Warner Bros. | false |
| 4 | Ojos Rojos | - | - | - | $579,117 | 31 | $585,640 | May 6 | - | false |
| 5 | Clash of the Titans | - | - | - | $526,993 | 103 | $1,828,161 | Apr 15 | Warner Bros. | false |
| 6 | Prince of Persia: The Sands of Time | - | - | - | $410,757 | 85 | $1,269,138 | May 27 | Walt Disney Pictures | false |
| 7 | The Book of Eli | - | - | - | $247,336 | 37 | $254,655 | May 6 | Sony Pictures Releasing | false |
| 8 | How to Train Your Dragon | - | - | - | $235,587 | 69 | $1,511,998 | Mar 25 | United International Pictures | false |
| 9 | Shutter Island | - | - | - | $232,951 | 35 | $739,576 | Apr 8 | United International Pictures | false |
| 10 | La Esmeralda 1879 | - | - | - | $154,993 | 35 | $192,205 | May 20 | - | false |
| 11 | Date Night | - | - | - | $123,144 | 30 | $127,418 | May 6 | 20th Century Fox International | false |
| 12 | The Girl with the Dragon Tattoo | - | - | - | $90,633 | 12 | $144,435 | Apr 22 | Andes Films | false |
| 13 | Remember Me | - | - | - | $60,809 | 17 | $103,496 | Apr 22 | - | false |
| 14 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $55,440 | 15 | $60,802 | May 20 | - | false |
| 15 | The Bounty Hunter | - | - | - | $52,709 | 22 | $113,902 | Apr 22 | Sony Pictures Releasing | false |
| 16 | Love Happens | - | - | - | $41,571 | 17 | $41,571 | May 6 | - | false |
| 17 | The Young Victoria | - | - | - | $21,460 | 8 | $71,748 | Apr 15 | - | false |
| 18 | Spread | - | - | - | $18,770 | 9 | $18,770 | Apr 29 | - | false |
| 19 | Let it Rain | - | - | - | $11,608 | 1 | $11,608 | May 6 | - | false |
| 20 | Law Abiding Citizen | - | - | - | $6,442 | 19 | $29,385 | Apr 22 | Transeuropa | false |
| 21 | Avatar | - | - | - | $6,397 | 124 | $10,818,765 | Dec 17 | 20th Century Fox International | false |
| 22 | Legion | - | - | - | $5,756 | 26 | $444,893 | Mar 25 | Sony Pictures Releasing | false |
| 23 | The Secret in Their Eyes | - | - | - | $4,787 | 3 | $446,321 | Jan 7 | - | false |
| 24 | Edge of Darkness | - | - | - | $2,384 | 30 | $184,033 | Apr 1 | Warner Bros. | false |
| 25 | Let the Right One In | - | - | - | $2,087 | 5 | $54,580 | Mar 25 | - | false |
| 26 | The Men Who Stare at Goats | - | - | - | $1,915 | 9 | $42,713 | Apr 1 | Sony Pictures Releasing | false |
| 27 | The Haunting in Connecticut | - | - | - | $1,701 | 13 | $214,186 | Jan 14 | Transeuropa | false |
| 28 | 500 Days of Summer | - | - | - | $682 | 8 | $132,235 | Mar 11 | 20th Century Fox International | false |
| 29 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $632 | 54 | $1,424,935 | Jan 28 | 20th Century Fox International | false |
| 30 | The Imaginarium of Doctor Parnassus | - | - | - | $492 | 6 | $90,374 | Jan 28 | Sony Pictures Releasing | false |
| 31 | The Blind Side | - | - | - | $305 | 8 | $96,354 | Mar 18 | Warner Bros. | false |
| 32 | The Burning Plain | - | - | - | $244 | 3 | $8,106 | Apr 8 | - | false |
| 33 | My Life in Ruins | - | - | - | $221 | 15 | $25,982 | Apr 8 | - | false |
| 34 | Daybreakers | - | - | - | $113 | 16 | $57,831 | Apr 1 | - | false |
| 35 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $19 | 50 | $803,087 | Feb 11 | 20th Century Fox International | false |
