| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man 2 | - | - | - | $2,483,677 | 101 | $2,566,778 | Apr 29 | Paramount Pictures International | false |
| 2 | Robin Hood | - | - | - | $2,219,387 | 116 | $2,992,530 | May 13 | Universal Pictures International (UPI) | false |
| 3 | Carancho | - | - | - | $1,731,311 | 67 | $2,525,489 | May 6 | Walt Disney Pictures | false |
| 4 | Clash of the Titans | - | - | - | $1,432,317 | 114 | $3,978,951 | Apr 15 | Warner Bros. | false |
| 5 | A Nightmare on Elm Street | - | - | - | $973,856 | 48 | $1,163,151 | May 6 | Warner Bros. | false |
| 6 | Prince of Persia: The Sands of Time | - | - | - | $907,596 | 99 | $3,101,060 | May 27 | Walt Disney Pictures | false |
| 7 | Garfield's Pet Force | - | - | - | $692,361 | 34 | $877,854 | May 13 | CDI Films | false |
| 8 | How to Train Your Dragon | - | - | - | $502,410 | 127 | $2,127,376 | Mar 25 | Paramount Pictures International | false |
| 9 | The Ghost Writer | - | - | - | $459,680 | 42 | $789,829 | May 13 | Alfa Films | false |
| 10 | Alice in Wonderland | - | - | - | $379,326 | 155 | $8,193,223 | Mar 4 | Walt Disney Pictures | false |
| 11 | Brother and Sister | - | - | - | $293,971 | 69 | $1,810,863 | Apr 1 | Primer Plano Film Group | false |
| 12 | The Back-up Plan | - | - | - | $187,692 | 31 | $291,820 | May 20 | Sony Pictures Releasing | false |
| 13 | Hachi: A Dog's Tale | - | - | - | $173,057 | 36 | $312,385 | May 20 | - | false |
| 14 | From Paris with Love | - | - | - | $134,398 | 44 | $133,729 | May 6 | - | false |
| 15 | Brooklyn's Finest 2010 Re-release | - | - | - | $117,949 | 48 | $172,005 | May 20 | Distribution Company | false |
| 16 | Remember Me | - | - | - | $98,881 | 29 | $305,441 | Apr 8 | Alfa Films | false |
| 17 | The Men Who Stare at Goats | - | - | - | $95,640 | 30 | $195,188 | Apr 22 | Sony Pictures Releasing | false |
| 18 | The White Ribbon | - | - | - | $95,392 | 15 | $180,975 | Apr 22 | - | false |
| 19 | Shutter Island | - | - | - | $80,787 | 45 | $1,578,795 | Mar 11 | Paramount Pictures International | false |
| 20 | Marmaduke | - | - | - | $67,713 | 31 | $201,229 | May 27 | 20th Century Fox International | false |
| 21 | The Beaches of Agnès | - | - | - | $62,299 | 8 | $65,961 | Apr 29 | IFA | false |
| 22 | It's Alive | - | - | - | $55,473 | 21 | $118,181 | Apr 22 | Distribution Company | false |
| 23 | Case 39 | - | - | - | $53,645 | 32 | $273,176 | Apr 8 | Paramount Pictures International | false |
| 24 | Date Night | - | - | - | $52,572 | 45 | $369,744 | Apr 8 | 20th Century Fox International | false |
| 25 | Avatar | - | - | - | $51,985 | 148 | $13,778,096 | Jan 1 | 20th Century Fox International | false |
| 26 | Battle for Terra | - | - | - | $50,940 | 32 | $81,176 | May 27 | Distribution Company | false |
| 27 | A Single Man | - | - | - | $39,634 | 13 | $94,927 | Apr 22 | - | false |
| 28 | Love Happens | - | - | - | $39,502 | 33 | $172,917 | Apr 15 | Distribution Company | false |
| 29 | Synecdoche, New York | - | - | - | $34,392 | 10 | $34,392 | Apr 29 | Distribution Company | false |
| 30 | Brideshead Revisited | - | - | - | $31,618 | 9 | $96,499 | May 27 | Impacto Cine | false |
| 31 | Ex | - | - | - | $29,883 | 19 | $73,365 | Apr 22 | Primer Plano Film Group | false |
| 32 | El mural | - | - | - | $20,746 | 21 | $137,066 | May 20 | - | false |
| 33 | The Bounty Hunter | - | - | - | $19,522 | 43 | $344,433 | Apr 1 | Sony Pictures Releasing | false |
| 34 | The Fourth Kind | - | - | - | $18,175 | 25 | $173,769 | Apr 1 | Alfa Films | false |
| 35 | Seraphine | - | - | - | $18,110 | 11 | $110,486 | Apr 1 | - | false |
| 36 | Me Two 2010 Re-release | - | - | - | $16,592 | 15 | $16,592 | May 6 | Distribution Company | false |
| 37 | The Blind Side | - | - | - | $15,870 | 33 | $308,898 | Mar 18 | Warner Bros. | false |
| 38 | The Box | - | - | - | $15,148 | 18 | $75,812 | Apr 15 | Alfa Films | false |
| 39 | Zenitram | - | - | - | $14,373 | 31 | $20,600 | May 20 | Primer Plano Film Group | false |
| 40 | Hadewijch | - | - | - | $14,054 | 4 | $25,715 | May 20 | CDI Films | false |
| 41 | Eva and Lola | - | - | - | $13,297 | 10 | $15,452 | May 13 | Primer Plano Film Group | false |
| 42 | Jerichow | - | - | - | $11,271 | 4 | $15,705 | May 20 | Alfa Films | false |
| 43 | The Book of Eli | - | - | - | $9,268 | 41 | $591,241 | Mar 18 | Sony Pictures Releasing | false |
| 44 | Birds of Paradise | - | - | - | $6,965 | 41 | $48,538 | Feb 18 | Sony Pictures Releasing | false |
| 45 | Ricky | - | - | - | $5,453 | 8 | $5,453 | Apr 29 | Impacto Cine | false |
| 46 | Couples Retreat | - | - | - | $5,027 | 23 | $167,416 | Mar 4 | Universal Pictures International (UPI) | false |
| 47 | The Rebound | - | - | - | $4,386 | 28 | $124,134 | Mar 25 | Alfa Films | false |
| 48 | Remembering the Children | - | - | - | $4,169 | 10 | $56,849 | Apr 8 | Distribution Company | false |
| 49 | Everybody's Fine | - | - | - | $4,094 | 28 | $190,231 | Mar 18 | Walt Disney Pictures | false |
| 50 | Dear John | - | - | - | $2,985 | 30 | $69,939 | Apr 15 | Sony Pictures Releasing | false |
| 51 | Edge of Darkness | - | - | - | $2,966 | 65 | $1,141,602 | Feb 25 | Warner Bros. | false |
| 52 | Precious | - | - | - | $2,923 | 31 | $303,251 | Feb 11 | - | false |
| 53 | Crazy Heart | - | - | - | $2,165 | 11 | $109,394 | Mar 11 | 20th Century Fox International | false |
| 54 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $1,929 | 98 | $1,090,189 | Jan 21 | 20th Century Fox International | false |
| 55 | Paco | - | - | - | $1,904 | 42 | $183,358 | Mar 18 | Primer Plano Film Group | false |
| 56 | Redacted 2010 Re-release | - | - | - | $1,841 | 6 | $1,841 | May 13 | Distribution Company | false |
| 57 | Dilettante | - | - | - | $1,828 | 1 | $1,828 | May 6 | Primer Plano Film Group | false |
| 58 | Did You Hear About the Morgans? | - | - | - | $989 | 30 | $283,813 | Mar 11 | Sony Pictures Releasing | false |
| 59 | Puzzle | - | - | - | $701 | 1 | $21,280 | Apr 29 | Primer Plano Film Group | false |
| 60 | Astro Boy | - | - | - | $625 | 29 | $174,796 | Jan 28 | Alfa Films | false |
| 61 | The Hurt Locker | - | - | - | $555 | 51 | $791,443 | Feb 4 | Distribution Company | false |
| 62 | Gods 2010 Re-release | - | - | - | $555 | 1 | $1,389 | May 27 | - | false |
| 63 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $404 | 33 | $175,545 | Mar 4 | Distribution Company | false |
| 64 | The Wolfman | - | - | - | $267 | 67 | $1,121,565 | Feb 11 | Universal Pictures International (UPI) | false |
| 65 | Brothers | - | - | - | $253 | 67 | $1,493,496 | Mar 25 | Distribution Company | false |
| 66 | 9 | - | - | - | $111 | 19 | $38,881 | Mar 18 | Distribution Company | false |
| 67 | The Girl with the Dragon Tattoo | - | - | - | $77 | 23 | $278,936 | Feb 18 | - | false |
| 68 | Old Dogs | - | - | - | $51 | 68 | $1,506,322 | Jan 21 | Walt Disney Pictures | false |
| 69 | Fame | - | - | - | $25 | 37 | $57,537 | Apr 1 | Impacto Cine | false |
