| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $1,161,440 | 102 | $1,453,509 | May 15 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $209,319 | 26 | $249,039 | Apr 30 | 20th Century Fox International | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $161,747 | 27 | $307,697 | May 21 | 20th Century Fox International | false |
| 4 | The Unborn | - | - | - | $86,425 | 15 | $89,568 | May 8 | United International Pictures | false |
| 5 | Paul Blart: Mall Cop | - | - | - | $61,441 | 27 | $300,180 | Apr 9 | Sony Pictures Releasing | false |
| 6 | Knowing | - | - | - | $58,926 | 12 | $62,620 | May 8 | - | false |
| 7 | Star Trek | - | - | - | $51,748 | 12 | $53,814 | May 8 | United International Pictures | false |
| 8 | Ghosts of Girlfriends Past | - | - | - | $51,422 | 13 | $103,118 | May 22 | Warner Bros. | false |
| 9 | Monsters vs. Aliens | - | - | - | $49,968 | 25 | $196,497 | Apr 3 | United International Pictures | false |
| 10 | Hannah Montana: The Movie | - | - | - | $49,188 | 12 | $65,081 | May 15 | Walt Disney Pictures | false |
| 11 | Race to Witch Mountain | - | - | - | $41,255 | 17 | $132,877 | Apr 17 | Walt Disney Pictures | false |
| 12 | 17 Again | - | - | - | $40,434 | 14 | $81,411 | Apr 24 | Warner Bros. | false |
| 13 | Underworld: Rise of the Lycans | - | - | - | $38,758 | 30 | $310,431 | Mar 27 | Sony Pictures Releasing | false |
| 14 | Fast & Furious | - | - | - | $19,586 | 25 | $345,890 | Apr 3 | United International Pictures | false |
| 15 | Duplicity | - | - | - | $13,582 | 11 | $47,118 | May 29 | United International Pictures | false |
| 16 | The Flock | - | - | - | $10,098 | 6 | $10,098 | Apr 30 | - | false |
| 17 | Rudo y Cursi | - | - | - | $10,075 | 11 | $10,729 | May 1 | United International Pictures | false |
| 18 | Earth | - | - | - | $9,928 | 4 | $24,513 | Apr 22 | Walt Disney Pictures | false |
| 19 | Milk | - | - | - | $9,530 | 8 | $9,530 | May 8 | United International Pictures | false |
| 20 | Doubt | - | - | - | $7,571 | 6 | $118,185 | May 15 | Walt Disney Pictures | false |
| 21 | Slumdog Millionaire | - | - | - | $5,606 | 4 | $96,509 | Mar 20 | - | false |
| 22 | The Mist | - | - | - | $1,318 | 8 | $8,928 | Apr 24 | - | false |
| 23 | Dragonball: Evolution | - | - | - | $982 | 21 | $63,749 | Apr 9 | 20th Century Fox International | false |
| 24 | The Boy in the Striped Pajamas | - | - | - | $351 | 5 | $36,939 | Mar 27 | Walt Disney Pictures | false |
