| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $2,781,346 | 89 | $4,444,803 | May 15 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $2,342,840 | 72 | $2,524,914 | Apr 30 | 20th Century Fox International | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $2,145,936 | 82 | $4,372,866 | May 22 | 20th Century Fox International | false |
| 4 | Race to Witch Mountain | - | - | - | $1,501,890 | 40 | $1,838,367 | May 1 | Walt Disney Pictures | false |
| 5 | Fast & Furious | - | - | - | $906,178 | 65 | $4,604,144 | Apr 3 | United International Pictures | false |
| 6 | Star Trek | - | - | - | $552,893 | 45 | $568,721 | May 8 | United International Pictures | false |
| 7 | Coraline | - | - | - | $523,794 | 37 | $545,266 | May 6 | United International Pictures | false |
| 8 | He's Just Not That Into You | - | - | - | $477,004 | 27 | $513,899 | May 1 | - | false |
| 9 | The Accidental Husband | - | - | - | $402,415 | 26 | $505,288 | May 15 | Walt Disney Pictures | false |
| 10 | Monsters vs. Aliens | - | - | - | $336,032 | 81 | $3,033,291 | Apr 3 | United International Pictures | false |
| 11 | The Strangers | - | - | - | $285,515 | 23 | $485,189 | Apr 24 | - | false |
| 12 | Earth | - | - | - | $224,463 | 11 | $367,734 | Apr 24 | Walt Disney Pictures | false |
| 13 | Knowing | - | - | - | $201,212 | 41 | $817,528 | May 29 | - | false |
| 14 | Slumdog Millionaire | - | - | - | $168,352 | 27 | $1,748,182 | Feb 27 | - | false |
| 15 | Solstice | - | - | - | $143,564 | 15 | $248,308 | May 22 | - | false |
| 16 | Catacombs | - | - | - | $125,412 | 15 | $216,775 | Apr 24 | - | false |
| 17 | Role Models | - | - | - | $123,616 | 30 | $277,708 | Apr 24 | United International Pictures | false |
| 18 | Inkheart | - | - | - | $101,536 | 26 | $953,627 | Mar 27 | - | false |
| 19 | Balls of Fury | - | - | - | $89,566 | 12 | $238,255 | Apr 17 | - | false |
| 20 | Paris, Je T'aime | - | - | - | $81,859 | 5 | $135,749 | May 15 | - | false |
| 21 | Paul Blart: Mall Cop | - | - | - | $76,495 | 35 | $1,305,828 | Mar 13 | Sony Pictures Releasing | false |
| 22 | Swing con son | - | - | - | $51,501 | 9 | $79,165 | Apr 24 | - | false |
| 23 | Milk | - | - | - | $49,778 | 18 | $65,571 | May 8 | United International Pictures | false |
| 24 | Flawless | - | - | - | $49,033 | 12 | $213,503 | May 29 | - | false |
| 25 | Underworld: Rise of the Lycans | - | - | - | $47,565 | 31 | $1,033,059 | Mar 27 | Sony Pictures Releasing | false |
| 26 | Dragonball Evolution | - | - | - | $46,454 | 58 | $1,143,339 | Apr 8 | 20th Century Fox International | false |
| 27 | Sex Drive | - | - | - | $37,339 | 21 | $212,030 | Apr 17 | - | false |
| 28 | The Diving Bell and the Butterfly | - | - | - | $31,303 | 3 | $68,100 | May 22 | - | false |
| 29 | Confessions of a Shopaholic | - | - | - | $27,476 | 37 | $962,748 | Mar 27 | Walt Disney Pictures | false |
| 30 | Swing Vote | - | - | - | $26,889 | 10 | $92,837 | May 29 | - | false |
| 31 | Pride and Glory | - | - | - | $19,266 | 20 | $162,496 | Apr 17 | - | false |
| 32 | The Band's Visit | - | - | - | $14,844 | 4 | $15,489 | May 1 | - | false |
| 33 | Chaos | - | - | - | $10,141 | 15 | $218,145 | Apr 10 | - | false |
| 34 | Captivity | - | - | - | $5,895 | 17 | $296,357 | Mar 27 | - | false |
| 35 | Smart People | - | - | - | $3,798 | 3 | $38,959 | Apr 17 | - | false |
| 36 | The Painted Veil | - | - | - | $2,465 | 7 | $101,574 | Apr 3 | - | false |
| 37 | The International | - | - | - | $2,239 | 25 | $573,995 | Mar 6 | Sony Pictures Releasing | false |
| 38 | The Pope's Toilet | - | - | - | $2,060 | 3 | $4,366 | May 29 | - | false |
