| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $191,929 | 14 | $314,045 | May 15 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $68,179 | 9 | $73,958 | Apr 29 | 20th Century Fox International | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $60,876 | 11 | $160,290 | May 22 | 20th Century Fox International | false |
| 4 | Flawless | - | - | - | $36,026 | 4 | $51,122 | Apr 24 | - | false |
| 5 | Jonas Brothers: The 3D Concert Experience | - | - | - | $34,050 | 4 | $35,982 | May 15 | Walt Disney Pictures | false |
| 6 | Race to Witch Mountain | - | - | - | $32,645 | 7 | $36,226 | May 8 | Walt Disney Pictures | false |
| 7 | Monsters vs. Aliens | - | - | - | $30,399 | 10 | $218,719 | Apr 3 | Paramount Pictures International | false |
| 8 | Summer Hours | - | - | - | $24,244 | 3 | $28,880 | Apr 29 | - | false |
| 9 | Paul Blart: Mall Cop | - | - | - | $23,605 | 8 | $81,975 | Apr 9 | Sony Pictures Releasing | false |
| 10 | Giant | - | - | - | $19,187 | 4 | $51,325 | May 22 | - | false |
| 11 | Righteous Kill | - | - | - | $18,949 | 5 | $57,520 | Apr 17 | - | false |
| 12 | Gran Torino | - | - | - | $16,773 | 7 | $133,412 | Mar 20 | Warner Bros. | false |
| 13 | Dan in Real Life | - | - | - | $15,708 | 2 | $16,228 | May 8 | - | false |
| 14 | He's Just Not That Into You | - | - | - | $15,481 | 7 | $75,006 | May 29 | - | false |
| 15 | Fast & Furious | - | - | - | $15,177 | 6 | $54,936 | May 29 | Universal Pictures International (UPI) | false |
| 16 | Hotel for Dogs | - | - | - | $11,711 | 6 | $59,054 | Mar 20 | Paramount Pictures International | false |
| 17 | Fados | - | - | - | $11,279 | 1 | $17,699 | May 8 | - | false |
| 18 | Duplicity | - | - | - | $11,149 | 7 | $33,550 | May 29 | Universal Pictures International (UPI) | false |
| 19 | Slumdog Millionaire | - | - | - | $10,619 | 6 | $285,996 | Feb 13 | - | false |
| 20 | The Strangers | - | - | - | $8,944 | 3 | $20,809 | May 22 | - | false |
| 21 | Earth | - | - | - | $8,826 | 1 | $15,029 | Apr 24 | Walt Disney Pictures | false |
| 22 | Deception | - | - | - | $8,178 | 3 | $21,663 | Apr 17 | - | false |
| 23 | The Unborn | - | - | - | $7,351 | 4 | $7,351 | May 15 | United International Pictures | false |
| 24 | My Mom's New Boyfriend | - | - | - | $6,943 | 3 | $12,318 | Apr 17 | - | false |
| 25 | Lust, Caution | - | - | - | $5,300 | 1 | $6,754 | Apr 29 | - | false |
| 26 | Hunting and Gathering | - | - | - | $3,877 | 2 | $18,589 | Mar 20 | - | false |
| 27 | Elegy | - | - | - | $3,118 | 2 | $22,332 | Mar 27 | - | false |
| 28 | Lamb of God | - | - | - | $2,496 | 3 | $5,031 | Apr 24 | - | false |
| 29 | Red Like the Sky 2008 Re-release | - | - | - | $2,161 | 2 | $2,161 | May 8 | - | false |
| 30 | Dragonball Evolution | - | - | - | $2,056 | 5 | $35,681 | Apr 10 | 20th Century Fox International | false |
| 31 | Watchmen | - | - | - | $2,017 | 5 | $13,224 | Apr 17 | Paramount Pictures International | false |
| 32 | Confessions of a Shopaholic | - | - | - | $1,597 | 5 | $38,072 | Mar 27 | Walt Disney Pictures | false |
| 33 | U2 3D | - | - | - | $1,301 | 1 | $43,539 | Feb 6 | - | false |
| 34 | Rudo y Cursi | - | - | - | $673 | 5 | $4,663 | Apr 24 | Universal Pictures International (UPI) | false |
| 35 | Underworld: Rise of the Lycans | - | - | - | $539 | 3 | $21,169 | Apr 3 | Sony Pictures Releasing | false |
| 36 | The Secret Life of Bees | - | - | - | $406 | 3 | $7,102 | Apr 9 | 20th Century Fox International | false |
| 37 | Stranded | - | - | - | $262 | 8 | $99,970 | Mar 6 | - | false |
| 38 | Inkheart | - | - | - | $249 | 4 | $12,459 | Apr 3 | - | false |
| 39 | The Forbidden Kingdom | - | - | - | $201 | 1 | $201 | May 8 | - | false |
| 40 | The Pink Panther 2 | - | - | - | $115 | 10 | $99,408 | Feb 13 | Sony Pictures Releasing | false |
| 41 | The International | - | - | - | $93 | 6 | $56,028 | Mar 27 | Sony Pictures Releasing | false |
