| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $1,351,445 | 100 | $1,577,031 | May 14 | Sony Pictures Releasing | false |
| 2 | Night at the Museum: Battle of the Smithsonian | - | - | - | $580,572 | 94 | $786,266 | May 21 | Gemini Films | false |
| 3 | X-Men Origins: Wolverine | - | - | - | $475,859 | 80 | $483,429 | Apr 30 | 20th Century Fox International | false |
| 4 | Star Trek | - | - | - | $394,380 | 78 | $408,398 | May 7 | Paramount Pictures International | false |
| 5 | Dark Planet: Rebellion | - | - | - | $303,577 | 85 | $617,179 | Apr 23 | Gemini Films | false |
| 6 | Coraline | - | - | - | $199,903 | 55 | $203,758 | Apr 30 | Universal Pictures International (UPI) | false |
| 7 | Race to Witch Mountain | - | - | - | $103,720 | 40 | $203,636 | Apr 23 | Walt Disney Pictures | false |
| 8 | The Boat That Rocked | - | - | - | $81,400 | 40 | $81,400 | May 7 | Universal Pictures International (UPI) | false |
| 9 | I Love You, Man | - | - | - | $64,235 | 40 | $244,972 | Apr 9 | Paramount Pictures International | false |
| 10 | Observe and Report | - | - | - | $59,488 | 30 | $67,057 | May 14 | Warner Bros. | false |
| 11 | Monsters vs. Aliens | - | - | - | $52,797 | 81 | $842,356 | Mar 19 | Paramount Pictures International | false |
| 12 | Fast & Furious | - | - | - | $48,900 | 71 | $1,007,293 | Apr 9 | Universal Pictures International (UPI) | false |
| 13 | He's Just Not That Into You | - | - | - | $10,928 | 62 | $290,724 | Mar 30 | Warner Bros. | false |
| 14 | Crank: High Voltage | - | - | - | $7,907 | 58 | $465,690 | Apr 16 | Central Partnership | false |
| 15 | Taras Bulba | - | - | - | $6,372 | 90 | $1,834,005 | Apr 2 | Central Partnership | false |
| 16 | 12 Rounds | - | - | - | $5,464 | 25 | $35,702 | Apr 16 | 20th Century Fox International | false |
| 17 | Easy Virtue | - | - | - | $4,361 | 16 | $92,346 | Apr 23 | Aurora | false |
| 18 | Dragonball Evolution | - | - | - | $1,929 | 31 | $44,350 | Apr 2 | 20th Century Fox International | false |
| 19 | Gran Torino | - | - | - | $862 | 2 | $7,469 | Apr 9 | Warner Bros. | false |
| 20 | Duplicity | - | - | - | $175 | 44 | $184,725 | Mar 26 | Universal Pictures International (UPI) | false |
| 21 | Watchmen | - | - | - | $43 | 65 | $443,139 | Mar 5 | Paramount Pictures International | false |
| 22 | First Love: It's the Music! | - | - | - | $12 | 30 | $67,559 | Mar 19 | 20th Century Fox International | false |
