| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $240,024 | 15 | $455,824 | May 14 | Sony Pictures Releasing | false |
| 2 | 17 Again | - | - | - | $71,517 | 6 | $99,116 | Apr 30 | Warner Bros. | false |
| 3 | I Love You, Man | - | - | - | $67,449 | 9 | $140,002 | Apr 23 | United International Pictures | false |
| 4 | X-Men Origins: Wolverine | - | - | - | $59,880 | 8 | $72,458 | Apr 30 | 20th Century Fox International | false |
| 5 | Star Trek | - | - | - | $57,259 | 5 | $80,117 | May 7 | United International Pictures | false |
| 6 | Duplicity | - | - | - | $56,431 | 8 | $75,045 | Apr 30 | United International Pictures | false |
| 7 | Night at the Museum: Battle of the Smithsonian | - | - | - | $47,450 | 11 | $131,517 | May 21 | 20th Century Fox International | false |
| 8 | Fast & Furious | - | - | - | $42,631 | 9 | $334,388 | Apr 9 | United International Pictures | false |
| 9 | Monsters vs. Aliens | - | - | - | $37,613 | 14 | $218,376 | Apr 2 | United International Pictures | false |
| 10 | My Bloody Valentine | - | - | - | $35,164 | 4 | $87,559 | May 21 | - | false |
| 11 | Coraline | - | - | - | $27,395 | 9 | $60,658 | May 14 | United International Pictures | false |
| 12 | Slumdog Millionaire | - | - | - | $25,920 | 8 | $320,740 | Mar 19 | Blitz | false |
| 13 | Gran Torino | - | - | - | $21,328 | 5 | $81,382 | Apr 9 | Warner Bros. | false |
| 14 | Beverly Hills Chihuahua | - | - | - | $15,979 | 6 | $53,738 | May 21 | Walt Disney Pictures | false |
| 15 | Taxi 4 | - | - | - | $15,346 | 2 | $22,447 | May 7 | - | false |
| 16 | State of Play | - | - | - | $8,990 | 7 | $42,425 | May 28 | United International Pictures | false |
| 17 | Race to Witch Mountain | - | - | - | $8,682 | 6 | $39,459 | Apr 16 | Walt Disney Pictures | false |
| 18 | Marley & Me | - | - | - | $8,137 | 6 | $111,014 | Mar 26 | 20th Century Fox International | false |
| 19 | Confessions of a Shopaholic | - | - | - | $5,397 | 6 | $89,699 | Mar 19 | Walt Disney Pictures | false |
| 20 | Blindness | - | - | - | $3,950 | 1 | $4,273 | May 7 | - | false |
| 21 | The Wrestler | - | - | - | $3,512 | 4 | $16,970 | May 28 | - | false |
| 22 | The Reader | - | - | - | $1,850 | 2 | $79,637 | Mar 12 | Cinemania Group | false |
| 23 | He's Just Not That Into You | - | - | - | $1,431 | 6 | $132,728 | Mar 12 | Warner Bros. | false |
| 24 | Traitor | - | - | - | $954 | 2 | $7,017 | Apr 23 | - | false |
| 25 | Inkheart | - | - | - | $629 | 4 | $20,573 | Mar 26 | Warner Bros. | false |
