| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $1,153,595 | 52 | $1,339,785 | May 14 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $853,538 | 60 | $867,258 | Apr 30 | 20th Century Fox International | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $831,327 | 60 | $1,234,546 | May 21 | 20th Century Fox International | false |
| 4 | Hannah Montana: The Movie | - | - | - | $457,536 | 26 | $534,630 | May 7 | Walt Disney Pictures | false |
| 5 | My Bloody Valentine | - | - | - | $454,354 | 25 | $485,701 | Apr 30 | - | false |
| 6 | Star Trek | - | - | - | $392,100 | 40 | $418,859 | May 7 | Paramount Pictures International | false |
| 7 | 17 Again | - | - | - | $276,390 | 20 | $305,114 | Apr 30 | Warner Bros. | false |
| 8 | Ghosts of Girlfriends Past | - | - | - | $245,544 | 22 | $307,630 | May 14 | Warner Bros. | false |
| 9 | Paul Blart: Mall Cop | - | - | - | $214,286 | 38 | $383,632 | Apr 23 | Sony Pictures Releasing | false |
| 10 | The Unborn | - | - | - | $186,539 | 32 | $503,820 | May 28 | Universal Pictures International (UPI) | false |
| 11 | Race to Witch Mountain | - | - | - | $169,061 | 36 | $867,052 | Apr 9 | Walt Disney Pictures | false |
| 12 | Unrest 2009 Re-release | - | - | - | $105,044 | 20 | $325,339 | Apr 16 | - | false |
| 13 | The Accidental Husband | - | - | - | $75,860 | 24 | $223,925 | May 28 | Walt Disney Pictures | false |
| 14 | Flawless | - | - | - | $67,151 | 12 | $89,555 | May 7 | - | false |
| 15 | Monsters vs. Aliens | - | - | - | $66,694 | 48 | $964,561 | Apr 2 | Paramount Pictures International | false |
| 16 | Fast & Furious | - | - | - | $57,161 | 25 | $668,172 | Apr 2 | Universal Pictures International (UPI) | false |
| 17 | Earth | - | - | - | $50,562 | 8 | $104,560 | Apr 23 | Walt Disney Pictures | false |
| 18 | The Prize | - | - | - | $50,287 | 20 | $118,410 | Apr 30 | - | false |
| 19 | The Wrestler | - | - | - | $48,496 | 14 | $55,422 | May 21 | - | false |
| 20 | Funny Games | - | - | - | $46,104 | 15 | $59,923 | May 21 | - | false |
| 21 | The Counterfeiters | - | - | - | $41,851 | 7 | $41,851 | Apr 30 | - | false |
| 22 | Space Chimps | - | - | - | $29,076 | 25 | $207,357 | Feb 26 | - | false |
| 23 | The Milk of Sorrow | - | - | - | $23,187 | 24 | $763,882 | Mar 12 | - | false |
| 24 | Underworld: Rise of the Lycans | - | - | - | $13,843 | 24 | $286,161 | Mar 19 | Sony Pictures Releasing | false |
| 25 | Death Defying Acts | - | - | - | $12,872 | 14 | $81,894 | Apr 23 | - | false |
| 26 | Fireflies in the Garden 2008 Re-release | - | - | - | $12,721 | 5 | $53,300 | May 28 | - | false |
| 27 | Swing Vote | - | - | - | $9,284 | 12 | $61,424 | Apr 2 | - | false |
| 28 | The Women | - | - | - | $8,814 | 14 | $105,118 | Mar 19 | - | false |
| 29 | Confessions of a Shopaholic | - | - | - | $8,333 | 24 | $226,301 | Mar 26 | Walt Disney Pictures | false |
| 30 | The Ugly Duckling and Me! | - | - | - | $7,988 | 20 | $135,234 | Mar 12 | - | false |
| 31 | The International | - | - | - | $7,404 | 24 | $121,017 | Apr 16 | Sony Pictures Releasing | false |
| 32 | Dragonball Evolution | - | - | - | $6,170 | 50 | $448,035 | Apr 9 | 20th Century Fox International | false |
| 33 | The Return | - | - | - | $5,616 | 10 | $67,396 | Dec 11 | - | false |
| 34 | Gran Torino | - | - | - | $4,790 | 20 | $257,828 | Mar 19 | Warner Bros. | false |
| 35 | Role Models | - | - | - | $4,498 | 24 | $86,456 | Apr 16 | Universal Pictures International (UPI) | false |
| 36 | Mad Money | - | - | - | $4,474 | 12 | $70,106 | Feb 19 | - | false |
| 37 | Wild Child | - | - | - | $3,883 | 12 | $69,668 | Feb 26 | Universal Pictures International (UPI) | false |
| 38 | Rudo y Cursi | - | - | - | $1,439 | 30 | $33,383 | Apr 23 | Universal Pictures International (UPI) | false |
| 39 | Rec 2009 Re-release | - | - | - | $1,289 | 20 | $178,187 | Mar 12 | - | false |
| 40 | The Bank Job | - | - | - | $943 | 25 | $179,481 | Apr 9 | - | false |
| 41 | Doubt | - | - | - | $774 | 8 | $67,811 | Feb 12 | Walt Disney Pictures | false |
| 42 | Vicky Cristina Barcelona | - | - | - | $513 | 15 | $169,383 | Feb 26 | - | false |
| 43 | 12:08 East of Bucharest | - | - | - | $278 | 2 | $6,257 | Apr 9 | - | false |
