| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $4,717,664 | 132 | $7,760,800 | May 14 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $2,238,677 | 103 | $2,616,177 | Apr 30 | Warner Bros. | false |
| 3 | 17 Again | - | - | - | $1,398,592 | 70 | $2,303,876 | Apr 23 | RCV Film Distribution | false |
| 4 | Star Trek | - | - | - | $1,249,757 | 76 | $1,509,031 | May 7 | Universal Pictures International (UPI) | false |
| 5 | Night at the Museum: Battle of the Smithsonian | - | - | - | $1,167,828 | 102 | $2,317,341 | May 20 | Warner Bros. | false |
| 6 | He's Just Not That Into You | - | - | - | $836,686 | 86 | $1,747,003 | Apr 16 | Paradiso Entertainment | false |
| 7 | Monsters vs. Aliens | - | - | - | $755,876 | 180 | $2,201,054 | Apr 2 | Universal Pictures International (UPI) | false |
| 8 | Slumdog Millionaire | - | - | - | $734,289 | 48 | $5,268,767 | Feb 12 | Cinéart | false |
| 9 | The Reader | - | - | - | $637,510 | 36 | $2,000,700 | Apr 2 | Benelux Film Distributors | false |
| 10 | Knowing | - | - | - | $606,468 | 58 | $1,569,491 | Apr 9 | Independent Films | false |
| 11 | Beverly Hills Chihuahua | - | - | - | $536,037 | 60 | $1,019,753 | Apr 23 | Walt Disney Pictures | false |
| 12 | Fast & Furious | - | - | - | $436,692 | 103 | $3,559,229 | Apr 2 | Universal Pictures International (UPI) | false |
| 13 | Fighting | - | - | - | $345,315 | 39 | $592,992 | May 21 | Universal Pictures International (UPI) | false |
| 14 | Lemo | - | - | - | $295,006 | 106 | $652,168 | Apr 8 | Independent Films | false |
| 15 | The Haunting in Connecticut | - | - | - | $272,049 | 22 | $280,327 | Apr 30 | Benelux Film Distributors | false |
| 16 | The Last Days of Emma Blank | - | - | - | $245,446 | 22 | $309,112 | May 7 | A-Film Distribution | false |
| 17 | Sunshine Cleaning | - | - | - | $209,765 | 25 | $360,566 | May 14 | A-Film Distribution | false |
| 18 | Coraline | - | - | - | $206,039 | 90 | $344,879 | May 14 | Universal Pictures International (UPI) | false |
| 19 | The International | - | - | - | $130,999 | 40 | $427,019 | Apr 16 | Sony Pictures Releasing | false |
| 20 | Duplicity | - | - | - | $130,062 | 38 | $564,468 | May 28 | Universal Pictures International (UPI) | false |
| 21 | Bride Wars | - | - | - | $113,035 | 89 | $1,512,958 | Mar 26 | Warner Bros. | false |
| 22 | Coco Before Chanel | - | - | - | $102,751 | 31 | $966,553 | May 28 | RCV Film Distribution | false |
| 23 | My Bloody Valentine | - | - | - | $81,853 | 26 | $1,175,804 | Mar 12 | RCV Film Distribution | false |
| 24 | The Young Victoria | - | - | - | $81,766 | 22 | $152,956 | May 21 | Paradiso Entertainment | false |
| 25 | My Dad's a Detective | - | - | - | $75,506 | 43 | $188,552 | Apr 8 | RCV Film Distribution | false |
| 26 | I Love You, Man | - | - | - | $75,040 | 29 | $300,561 | May 28 | Universal Pictures International (UPI) | false |
| 27 | Street Fighter: The Legend of Chun-Li | - | - | - | $59,752 | 15 | $86,670 | May 7 | Independent Films | false |
| 28 | Eden Lake | - | - | - | $59,224 | 7 | $77,707 | May 14 | Benelux Film Distributors | false |
| 29 | The Uninvited | - | - | - | $28,527 | 33 | $198,929 | Apr 16 | Universal Pictures International (UPI) | false |
| 30 | Hotel for Dogs | - | - | - | $22,605 | 60 | $1,186,296 | Feb 19 | Universal Pictures International (UPI) | false |
| 31 | The Brothers Bloom | - | - | - | $22,360 | 20 | $90,921 | May 28 | A-Film Distribution | false |
| 32 | Inkheart | - | - | - | $22,031 | 40 | $97,770 | Apr 16 | Paradiso Entertainment | false |
| 33 | Casanegra | - | - | - | $20,108 | 3 | $20,108 | May 21 | Moonlight Films | false |
| 34 | Mammoth | - | - | - | $19,801 | 16 | $56,843 | Apr 23 | A-Film Distribution | false |
| 35 | The Boat That Rocked | - | - | - | $18,380 | 79 | $166,101 | Apr 16 | Universal Pictures International (UPI) | false |
| 36 | Dragonball Evolution | - | - | - | $18,309 | 60 | $382,916 | Apr 9 | Warner Bros. | false |
| 37 | The Burning Plain | - | - | - | $15,445 | 9 | $22,966 | May 14 | Cinéart | false |
| 38 | Gran Torino | - | - | - | $12,503 | 34 | $827,018 | Mar 12 | Warner Bros. | false |
