| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $8,253,803 | 800 | $13,379,208 | May 15 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $3,971,362 | 855 | $10,267,814 | Apr 30 | 20th Century Fox International | false |
| 3 | Ghosts of Girlfriends Past | - | - | - | $2,207,065 | 350 | $2,750,044 | May 15 | Warner Bros. | false |
| 4 | Hannah Montana: The Movie | - | - | - | $1,659,053 | 320 | $2,455,662 | May 22 | Walt Disney Pictures | false |
| 5 | Race to Witch Mountain | - | - | - | $1,138,513 | 360 | $4,560,558 | Mar 27 | Walt Disney Pictures | false |
| 6 | The Haunting in Connecticut | - | - | - | $1,122,375 | 300 | $2,705,122 | Apr 17 | Gussi Films | false |
| 7 | Earth | - | - | - | $837,645 | 116 | $950,290 | May 15 | Walt Disney Pictures | false |
| 8 | Igor | - | - | - | $837,373 | 250 | $1,097,430 | Apr 24 | Videocine | false |
| 9 | Knowing | - | - | - | $618,806 | 317 | $4,764,802 | Mar 27 | Corazón Films | false |
| 10 | Amar a morir | - | - | - | $611,840 | 322 | $2,656,911 | Apr 9 | Gussi Films | false |
| 11 | Fast & Furious | - | - | - | $568,143 | 654 | $13,210,004 | Apr 3 | Universal Pictures International (UPI) | false |
| 12 | Push | - | - | - | $538,955 | 154 | $837,940 | Mar 20 | - | false |
| 13 | Monsters vs. Aliens | - | - | - | $450,619 | 753 | $10,569,999 | Apr 3 | Paramount Pictures International | false |
| 14 | Gran Torino | - | - | - | $447,466 | 201 | $2,177,471 | Mar 27 | Warner Bros. | false |
| 15 | Sin Nombre | - | - | - | $430,881 | 199 | $610,225 | May 15 | Universal Pictures International (UPI) | false |
| 16 | El libro de piedra | - | - | - | $411,711 | 155 | $874,746 | Apr 17 | - | false |
| 17 | I Love You, Man | - | - | - | $400,307 | 201 | $601,354 | Apr 24 | Paramount Pictures International | false |
| 18 | Duplicity | - | - | - | $393,891 | 258 | $1,796,746 | Apr 9 | Universal Pictures International (UPI) | false |
| 19 | Up | - | - | - | $346,456 | 799 | $14,192,640 | Jun 5 | Walt Disney Pictures | false |
| 20 | Slumdog Millionaire | - | - | - | $287,695 | 225 | $6,390,432 | Feb 20 | Gussi Films | false |
| 21 | The Reader | - | - | - | $275,126 | 99 | $1,108,524 | Apr 3 | Gussi Films | false |
| 22 | The Last House on the Left | - | - | - | $195,734 | 174 | $445,028 | May 22 | Universal Pictures International (UPI) | false |
| 23 | The Accidental Husband | - | - | - | $142,997 | 250 | $1,286,202 | Apr 3 | Walt Disney Pictures | false |
| 24 | 12 Rounds | - | - | - | $139,068 | 80 | $321,345 | Apr 17 | 20th Century Fox International | false |
| 25 | Borderland | - | - | - | $97,551 | 79 | $253,200 | Apr 9 | Videocine | false |
| 26 | Then She Found Me | - | - | - | $96,956 | 59 | $159,322 | May 15 | Videocine | false |
| 27 | Street Fighter: The Legend of Chun-Li | - | - | - | $77,825 | 73 | $92,203 | May 22 | Gussi Films | false |
| 28 | Surveillance | - | - | - | $75,815 | 108 | $110,048 | Apr 24 | - | false |
| 29 | Insignificant Things | - | - | - | $74,994 | 100 | $251,897 | Apr 17 | Warner Bros. | false |
| 30 | The International | - | - | - | $70,497 | 150 | $888,873 | Mar 20 | Sony Pictures Releasing | false |
| 31 | Dragonball Evolution | - | - | - | $69,603 | 402 | $2,414,834 | Apr 9 | 20th Century Fox International | false |
| 32 | The Children of Huang Shi | - | - | - | $67,688 | 30 | $102,371 | Apr 24 | Gussi Films | false |
| 33 | Paul Blart: Mall Cop | - | - | - | $64,935 | 302 | $2,252,572 | Mar 13 | Sony Pictures Releasing | false |
| 34 | The Unborn | - | - | - | $53,590 | 352 | $5,249,945 | Mar 13 | Universal Pictures International (UPI) | false |
| 35 | In Bruges | - | - | - | $53,480 | 60 | $155,239 | Mar 20 | Corazón Films | false |
| 36 | Paraiso Travel | - | - | - | $38,072 | 52 | $60,046 | Apr 24 | - | false |
| 37 | Another Egg and Chicken Movie | - | - | - | $34,283 | 446 | $8,583,678 | Mar 20 | Videocine | false |
| 38 | Personal Effects | - | - | - | $33,787 | 30 | $106,897 | May 29 | Gussi Films | false |
| 39 | Cherry Blossoms | - | - | - | $31,647 | 14 | $82,225 | Apr 17 | - | false |
| 40 | The Girl in the Park | - | - | - | $31,472 | 21 | $35,546 | May 22 | - | false |
| 41 | Rachel Getting Married | - | - | - | $29,139 | 10 | $163,954 | Mar 20 | Sony Pictures Releasing | false |
| 42 | The Secret Life of Bees | - | - | - | $24,686 | 50 | $173,055 | Mar 13 | 20th Century Fox International | false |
| 43 | DOA: Dead or Alive 2009 Re-release | - | - | - | $16,110 | 30 | $18,990 | May 15 | Gussi Films | false |
| 44 | Elegy | - | - | - | $9,542 | 80 | $216,717 | Mar 13 | Corazón Films | false |
| 45 | When Did You Last See Your Father? | - | - | - | $8,417 | 11 | $22,833 | May 29 | - | false |
| 46 | Mister Lonely | - | - | - | $6,898 | 4 | $20,759 | May 29 | - | false |
| 47 | Underworld: Rise of the Lycans | - | - | - | $5,942 | 250 | $3,847,460 | Feb 6 | Sony Pictures Releasing | false |
| 48 | Desierto adentro | - | - | - | $1,954 | 20 | $48,966 | Mar 13 | Gussi Films | false |
| 49 | Boogeyman 2 | - | - | - | $1,466 | 25 | $82,216 | May 8 | Gussi Films | false |
| 50 | Standard Operating Procedure | - | - | - | $1,090 | 7 | $9,431 | Apr 3 | - | false |
| 51 | Dark Matter | - | - | - | $862 | 14 | $30,215 | Mar 27 | David Distribucion | false |
| 52 | The Pink Panther 2 | - | - | - | $622 | 375 | $2,178,265 | Feb 27 | Sony Pictures Releasing | false |
