| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $196,696 | 10 | $293,688 | May 15 | Sony Pictures Releasing | false |
| 2 | 17 Again | - | - | - | $123,597 | 7 | $131,594 | May 8 | Garsu Pasaulio Irasai | false |
| 3 | Monsters vs. Aliens | - | - | - | $58,487 | 10 | $232,224 | Apr 3 | Universal Pictures International (UPI) | false |
| 4 | X-Men Origins: Wolverine | - | - | - | $56,734 | 8 | $61,702 | May 1 | Universal Pictures International (UPI) | false |
| 5 | Night at the Museum: Battle of the Smithsonian | - | - | - | $47,401 | 8 | $104,857 | May 22 | Universal Pictures International (UPI) | false |
| 6 | Fast & Furious | - | - | - | $46,602 | 10 | $374,527 | Apr 3 | Universal Pictures International (UPI) | false |
| 7 | My Bloody Valentine | - | - | - | $45,878 | 8 | $124,231 | Apr 24 | ACME | false |
| 8 | Coraline | - | - | - | $37,946 | 2 | $51,771 | May 8 | Universal Pictures International (UPI) | false |
| 9 | Star Trek | - | - | - | $23,921 | 3 | $25,748 | May 8 | Universal Pictures International (UPI) | false |
| 10 | I Love You, Man | - | - | - | $21,588 | 6 | $37,227 | Apr 24 | Universal Pictures International (UPI) | false |
| 11 | Observe and Report | - | - | - | $21,465 | 5 | $22,897 | May 15 | Garsu Pasaulio Irasai | false |
| 12 | Bolt | - | - | - | $20,040 | 10 | $353,955 | Feb 27 | Universal Pictures International (UPI) | false |
| 13 | Fighting | - | - | - | $19,794 | 7 | $79,705 | May 29 | Universal Pictures International (UPI) | false |
| 14 | Taken | - | - | - | $16,578 | 7 | $33,413 | Apr 24 | ACME | false |
| 15 | The Uninvited | - | - | - | $14,380 | 3 | $22,666 | May 22 | Universal Pictures International (UPI) | false |
| 16 | Ghosts of Girlfriends Past | - | - | - | $13,685 | 7 | $67,524 | May 29 | Garsu Pasaulio Irasai | false |
| 17 | Knowing | - | - | - | $12,203 | 7 | $81,859 | Apr 10 | ACME | false |
| 18 | Confessions of a Shopaholic | - | - | - | $11,750 | 8 | $82,855 | Apr 10 | Universal Pictures International (UPI) | false |
| 19 | Crank: High Voltage | - | - | - | $10,020 | 7 | $92,134 | Apr 17 | ACME | false |
| 20 | Marley & Me | - | - | - | $7,619 | 8 | $139,599 | Mar 13 | Universal Pictures International (UPI) | false |
| 21 | Newsmakers | - | - | - | $7,118 | 3 | $7,338 | - | - | false |
| 22 | Race to Witch Mountain | - | - | - | $6,725 | 6 | $36,174 | Apr 17 | Universal Pictures International (UPI) | false |
| 23 | Push | - | - | - | $5,958 | 2 | $6,179 | May 22 | ACME | false |
| 24 | Madagascar: Escape 2 Africa | - | - | - | $5,924 | 10 | $748,906 | Nov 28 | Universal Pictures International (UPI) | false |
| 25 | Dark Planet: Rebellion | - | - | - | $5,505 | 5 | $11,096 | May 29 | ACME | false |
| 26 | Ice Age 2: The Meltdown | - | - | - | $5,466 | 3 | $665,174 | Apr 7 | Universal Pictures International (UPI) | false |
| 27 | Kung Fu Panda | - | - | - | $3,856 | 9 | $483,946 | Jun 6 | Universal Pictures International (UPI) | false |
| 28 | WALL·E | - | - | - | $3,839 | 10 | $420,941 | Jul 18 | Universal Pictures International (UPI) | false |
| 29 | Hotel for Dogs | - | - | - | $3,545 | 8 | $51,159 | Mar 20 | Universal Pictures International (UPI) | false |
| 30 | Gran Torino | - | - | - | $3,361 | 3 | $41,204 | Mar 27 | Garsu Pasaulio Irasai | false |
| 31 | Slumdog Millionaire | - | - | - | $3,324 | 4 | $286,818 | Feb 13 | ACME | false |
| 32 | The Tale of Despereaux | - | - | - | $2,861 | 10 | $282,007 | Dec 26 | Universal Pictures International (UPI) | false |
| 33 | Duplicity | - | - | - | $2,623 | 7 | $51,258 | Mar 20 | Universal Pictures International (UPI) | false |
| 34 | The Crimson Wing: Mystery of the Flamingos | - | - | - | $2,410 | 4 | $23,572 | Mar 13 | Universal Pictures International (UPI) | false |
| 35 | The Class | - | - | - | $2,398 | 3 | $23,770 | Apr 17 | - | false |
| 36 | Role Models | - | - | - | $1,960 | 3 | $35,144 | Feb 27 | Universal Pictures International (UPI) | false |
| 37 | Involuntary | - | - | - | $1,368 | 1 | $6,186 | Apr 3 | - | false |
| 38 | The Unborn | - | - | - | $308 | 7 | $91,195 | Mar 6 | Universal Pictures International (UPI) | false |
| 39 | Revolutionary Road | - | - | - | $257 | 4 | $57,055 | Jan 30 | Universal Pictures International (UPI) | false |
| 40 | Delta | - | - | - | $179 | 1 | $1,443 | May 29 | - | false |
| 41 | Ratatouille | - | - | - | $127 | 1 | $636,521 | Aug 17 | Universal Pictures International (UPI) | false |
| 42 | Watchmen | - | - | - | $96 | 6 | $52,728 | Mar 13 | Universal Pictures International (UPI) | false |
