| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $18,316,745 | 818 | $26,775,811 | May 13 | Sony Pictures Releasing | false |
| 2 | My Bloody Valentine | - | - | - | $7,717,455 | 278 | $8,725,914 | May 8 | Medusa Distribuzione | false |
| 3 | X-Men Origins: Wolverine | - | - | - | $6,005,055 | 407 | $6,945,272 | Apr 29 | 20th Century Fox International | false |
| 4 | Night at the Museum: Battle of the Smithsonian | - | - | - | $4,605,356 | 518 | $9,988,389 | May 22 | 20th Century Fox International | false |
| 5 | State of Play | - | - | - | $3,102,976 | 301 | $3,559,324 | Apr 30 | United International Pictures | false |
| 6 | Hannah Montana: The Movie | - | - | - | $3,086,635 | 346 | $3,279,336 | Apr 30 | Walt Disney Pictures | false |
| 7 | Star Trek | - | - | - | $2,965,409 | 327 | $3,127,646 | May 8 | United International Pictures | false |
| 8 | 17 Again | - | - | - | $1,812,249 | 328 | $2,211,411 | May 15 | Warner Bros. | false |
| 9 | Fast & Furious | - | - | - | $1,644,317 | 422 | $11,161,012 | Apr 17 | United International Pictures | false |
| 10 | Vincere | - | - | - | $1,431,953 | 302 | $2,991,766 | May 20 | 01 Distribution | false |
| 11 | The Girl with the Dragon Tattoo | - | - | - | $1,304,955 | 437 | $5,295,520 | May 29 | BIM Distribuzione | false |
| 12 | Questione di cuore | - | - | - | $1,264,364 | 264 | $3,919,677 | Apr 17 | 01 Distribution | false |
| 13 | Gran Torino | - | - | - | $1,209,300 | 332 | $12,993,866 | Mar 13 | Warner Bros. | false |
| 14 | Che: Part Two | - | - | - | $846,820 | 179 | $891,334 | May 1 | BIM Distribuzione | false |
| 15 | Generazione mille euro | - | - | - | $722,132 | 267 | $1,712,362 | Apr 24 | 01 Distribution | false |
| 16 | Death Defying Acts | - | - | - | $677,596 | 187 | $1,628,520 | Apr 24 | Eagle Pictures | false |
| 17 | Monsters vs. Aliens | - | - | - | $647,571 | 496 | $10,546,331 | Apr 3 | United International Pictures | false |
| 18 | Earth | - | - | - | $484,241 | 87 | $1,046,151 | Apr 22 | Walt Disney Pictures | false |
| 19 | Antichrist | - | - | - | $442,195 | 121 | $707,717 | May 22 | Lucky Red | false |
| 20 | Coco Before Chanel | - | - | - | $434,623 | 164 | $1,792,873 | May 29 | Warner Bros. | false |
| 21 | Marley & Me | - | - | - | $383,107 | 348 | $6,737,110 | Apr 3 | 20th Century Fox International | false |
| 22 | Feisbum | - | - | - | $334,209 | 200 | $335,452 | May 8 | - | false |
| 23 | Elegy | - | - | - | $280,132 | 34 | $291,499 | Apr 30 | 01 Distribution | false |
| 24 | Che: Part One | - | - | - | $266,509 | 208 | $2,749,408 | Apr 10 | BIM Distribuzione | false |
| 25 | The Friends at the Margherita Cafe | - | - | - | $262,257 | 265 | $4,326,733 | Apr 3 | 01 Distribution | false |
| 26 | How to Lose Friends & Alienate People | - | - | - | $251,935 | 156 | $251,935 | May 8 | Mikado Film | false |
| 27 | Diary of a Nymphomaniac | - | - | - | $250,472 | 82 | $273,790 | Apr 30 | Sony Pictures Releasing | false |
| 28 | The Tale of Despereaux | - | - | - | $230,676 | 103 | $645,683 | Apr 24 | United International Pictures | false |
| 29 | Sbirri | - | - | - | $223,633 | 224 | $2,385,262 | Apr 10 | Medusa Distribuzione | false |
| 30 | When a Man Comes Home 2009 Re-release | - | - | - | $215,533 | 32 | $222,480 | Apr 30 | Teodora Film | false |
| 31 | The Milk of Sorrow | - | - | - | $213,467 | 35 | $259,256 | May 8 | - | false |
| 32 | Chef's Special 2009 Re-release | - | - | - | $170,556 | 97 | $514,692 | Apr 24 | - | false |
| 33 | Terra madre | - | - | - | $121,505 | 24 | $192,935 | May 8 | BIM Distribuzione | false |
| 34 | Battle for Terra | - | - | - | $118,638 | 130 | $297,695 | May 29 | Sony Pictures Releasing | false |
| 35 | Just Friends 2009 Re-release | - | - | - | $111,809 | 75 | $111,809 | May 8 | Warner Bros. | false |
| 36 | Two Lovers | - | - | - | $90,492 | 108 | $1,339,026 | Mar 27 | BIM Distribuzione | false |
| 37 | Duplicity | - | - | - | $83,403 | 203 | $2,847,062 | Apr 10 | United International Pictures | false |
| 38 | Louise hires a contract killer | - | - | - | $75,948 | 48 | $803,171 | Apr 3 | Fandango | false |
| 39 | The Uninvited | - | - | - | $73,717 | 50 | $73,717 | May 29 | United International Pictures | false |
| 40 | Blood of the Losers | - | - | - | $72,576 | 35 | $74,062 | May 8 | 01 Distribution | false |
| 41 | Shadowless Sword 2009 Re-release | - | - | - | $66,885 | 18 | $66,885 | May 15 | Eagle Pictures | false |
| 42 | La casa sulle nuvole | - | - | - | $44,743 | 19 | $44,743 | May 8 | Istituto Luce | false |
| 43 | Tutta colpa di Giuda | - | - | - | $44,118 | 74 | $353,690 | Apr 10 | Warner Bros. | false |
| 44 | RocknRolla | - | - | - | $41,584 | 138 | $386,404 | Apr 24 | Walt Disney Pictures | false |
| 45 | Tulpan | - | - | - | $41,021 | 15 | $104,411 | Apr 24 | BIM Distribuzione | false |
| 46 | What Just Happened | - | - | - | $40,638 | 275 | $1,350,455 | Apr 17 | Medusa Distribuzione | false |
| 47 | Franklyn | - | - | - | $38,075 | 149 | $700,561 | Apr 17 | Sony Pictures Releasing | false |
| 48 | Cloud 9 | - | - | - | $27,919 | 17 | $145,980 | May 29 | Warner Bros. | false |
| 49 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $25,874 | 8 | $72,993 | Jun 20 | Walt Disney Pictures | false |
| 50 | Star Trek: Nemesis | - | - | - | $23,644 | 63 | $599,287 | May 16 | United International Pictures | false |
| 51 | Role Models | - | - | - | $23,593 | 99 | $23,593 | May 22 | United International Pictures | false |
| 52 | Choke | - | - | - | $18,749 | 10 | $22,858 | May 13 | 20th Century Fox International | false |
| 53 | La matassa | - | - | - | $12,118 | 514 | $10,007,765 | Mar 13 | Medusa Distribuzione | false |
| 54 | Slumdog Millionaire | - | - | - | $11,670 | 160 | $9,341,549 | Dec 5 | Lucky Red | false |
| 55 | The Reader | - | - | - | $8,489 | 161 | $3,645,596 | Feb 20 | 01 Distribution | false |
| 56 | Dragonball Evolution | - | - | - | $7,898 | 328 | $2,661,061 | Apr 10 | 20th Century Fox International | false |
| 57 | Ponyo | - | - | - | $7,010 | 184 | $1,013,560 | Mar 20 | Lucky Red | false |
