| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $203,871 | 6 | $287,459 | May 15 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $100,240 | 7 | $126,349 | May 1 | 20th Century Fox International | false |
| 3 | Star Trek | - | - | - | $89,304 | 5 | $101,352 | May 8 | United International Pictures | false |
| 4 | Night at the Museum: Battle of the Smithsonian | - | - | - | $45,469 | 6 | $92,573 | May 20 | 20th Century Fox International | false |
| 5 | 17 Again | - | - | - | $38,203 | 4 | $114,173 | Apr 17 | - | false |
| 6 | Monsters vs. Aliens | - | - | - | $32,432 | 13 | $160,780 | Apr 3 | United International Pictures | false |
| 7 | Dreamland | - | - | - | $31,319 | 3 | $123,238 | Apr 8 | - | false |
| 8 | The True Story of Puss'N Boots | - | - | - | $30,649 | 5 | $37,133 | May 1 | - | false |
| 9 | The Last House on the Left | - | - | - | $24,875 | 3 | $46,390 | May 22 | - | false |
| 10 | Observe and Report | - | - | - | $21,718 | 4 | $46,212 | Apr 24 | - | false |
| 11 | New in Town | - | - | - | $21,311 | 4 | $24,833 | May 1 | - | false |
| 12 | Hannah Montana: The Movie | - | - | - | $20,752 | 4 | $29,143 | May 13 | Walt Disney Pictures | false |
| 13 | I Love You, Man | - | - | - | $20,533 | 4 | $107,473 | Apr 10 | United International Pictures | false |
| 14 | The Boat That Rocked | - | - | - | $19,398 | 3 | $27,373 | May 8 | United International Pictures | false |
| 15 | Crank: High Voltage | - | - | - | $16,906 | 3 | $44,498 | Apr 24 | - | false |
| 16 | State of Play | - | - | - | $11,241 | 3 | $33,224 | Apr 17 | United International Pictures | false |
| 17 | Adventureland | - | - | - | $10,084 | 2 | $36,497 | May 29 | Walt Disney Pictures | false |
| 18 | The Unborn | - | - | - | $9,778 | 3 | $18,277 | Mar 27 | United International Pictures | false |
| 19 | Coraline | - | - | - | $7,168 | 3 | $27,221 | May 29 | United International Pictures | false |
| 20 | Fast & Furious | - | - | - | $6,527 | 5 | $145,551 | Apr 3 | United International Pictures | false |
| 21 | Let the Right One In | - | - | - | $5,123 | 1 | $15,808 | Apr 17 | - | false |
| 22 | Paul Blart: Mall Cop | - | - | - | $3,440 | 4 | $92,203 | Mar 27 | Sony Pictures Releasing | false |
| 23 | Franklin and the Turtle Lake Treasure 2009 Re-release | - | - | - | $2,332 | 6 | $13,038 | Apr 8 | - | false |
| 24 | Knowing | - | - | - | $1,359 | 4 | $74,799 | Mar 27 | Sam Film | false |
