| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $3,732,788 | 170 | $4,742,120 | May 13 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $1,407,355 | 93 | $1,546,965 | Apr 29 | 20th Century Fox International | false |
| 3 | My Life in Ruins | - | - | - | $696,499 | 120 | $1,871,896 | May 27 | - | false |
| 4 | Star Trek | - | - | - | $537,423 | 42 | $537,423 | May 7 | United International Pictures | false |
| 5 | Night at the Museum: Battle of the Smithsonian | - | - | - | $492,623 | 78 | $777,243 | May 21 | 20th Century Fox International | false |
| 6 | State of Play | - | - | - | $427,318 | 40 | $427,318 | Apr 30 | United International Pictures | false |
| 7 | Pain of Autumn | - | - | - | $254,157 | 17 | $254,157 | Apr 30 | Odeon | false |
| 8 | 17 Again | - | - | - | $241,295 | 23 | $241,295 | May 7 | Roadshow Films | false |
| 9 | Duplicity | - | - | - | $234,615 | 48 | $978,849 | Apr 16 | United International Pictures | false |
| 10 | Fast & Furious | - | - | - | $211,350 | 46 | $2,450,550 | Apr 2 | United International Pictures | false |
| 11 | Monsters vs. Aliens | - | - | - | $187,041 | 92 | $871,681 | Apr 2 | United International Pictures | false |
| 12 | The Last House on the Left | - | - | - | $113,763 | 28 | $295,310 | May 28 | Roadshow Films | false |
| 13 | Hotel for Dogs | - | - | - | $108,126 | 21 | $226,450 | Apr 16 | United International Pictures | false |
| 14 | Coraline | - | - | - | $55,730 | 29 | $142,150 | May 28 | United International Pictures | false |
| 15 | Confessions of a Shopaholic | - | - | - | $39,277 | 38 | $601,396 | Apr 9 | Walt Disney Pictures | false |
| 16 | The First Day of the Rest of Your Life | - | - | - | $33,837 | 3 | $33,837 | May 14 | Odeon | false |
| 17 | Crank: High Voltage | - | - | - | $30,626 | 22 | $174,370 | Apr 23 | Spentzos Films | false |
| 18 | My Stars | - | - | - | $12,415 | 3 | $12,415 | May 28 | - | false |
| 19 | The Broken | - | - | - | $8,145 | 6 | $8,145 | May 21 | Odeon | false |
| 20 | The International | - | - | - | $818 | 49 | $568,899 | Mar 19 | Sony Pictures Releasing | false |
