| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Star Trek | - | - | - | $35,392,062 | 499 | $9,059,797 | 25.6% | 499 | May 8 | - | Paramount Pictures International | false |
| 2 | Night at the Museum: Battle of the Smithsonian | - | - | - | $32,825,190 | 520 | $6,625,627 | 20.2% | 515 | May 21 | - | 20th Century Fox International | false |
| 3 | Angels & Demons | - | - | - | $30,726,140 | 512 | $7,763,481 | 25.3% | 506 | May 14 | - | Sony Pictures Releasing | false |
| 4 | Hannah Montana: The Movie | - | - | - | $13,937,675 | 449 | $3,029,249 | 21.7% | 415 | May 1 | - | Walt Disney Pictures | false |
| 5 | Coraline | - | - | - | $12,193,282 | 440 | $3,695,729 | 30.3% | 392 | May 8 | - | Universal Pictures International (UPI) | false |
| 6 | Drag Me to Hell | - | - | - | $10,503,062 | 408 | $3,087,393 | 29.4% | 397 | May 29 | - | Lionsgate | false |
| 7 | Ghosts of Girlfriends Past | - | - | - | $6,859,122 | 382 | $1,457,119 | 21.2% | 382 | May 1 | - | Entertainment Film Distributors | false |
| 8 | Fighting | - | - | - | $3,341,473 | 293 | $1,504,181 | 45% | 293 | May 15 | - | Universal Pictures International (UPI) | false |
| 9 | 12 Rounds | - | - | - | $1,187,641 | 300 | $528,886 | 44.5% | 300 | May 27 | - | 20th Century Fox International | false |
| 10 | Tormented | - | - | - | $1,147,307 | 234 | $453,478 | 39.5% | 234 | May 22 | - | Warner Bros. | false |
| 11 | Synecdoche, New York | - | - | - | $875,104 | 40 | $186,850 | 21.4% | 30 | May 15 | - | Revolver Entertainment | false |
| 12 | Obsessed | - | - | - | $854,917 | 149 | $249,784 | 29.2% | 149 | May 29 | - | Sony Pictures Releasing | false |
| 13 | Is Anybody There? | - | - | - | $768,921 | 96 | $183,947 | 23.9% | 96 | May 1 | - | Optimum Releasing | false |
| 14 | Chéri | - | - | - | $673,008 | 81 | $183,069 | 27.2% | 81 | May 8 | - | Warner Bros. | false |
| 15 | Jonas Brothers: The 3D Concert Experience | - | - | - | $409,245 | 169 | $189,445 | 46.3% | 169 | May 29 | - | Walt Disney Pictures | false |
| 16 | Munde U.K. De | - | - | - | $307,106 | 7 | $50,660 | 16.5% | 6 | May 8 | - | Tip Top Entertainment (TTE) | false |
| 17 | Mark of an Angel | - | - | - | $130,793 | 13 | $34,545 | 26.4% | 13 | May 22 | - | Metrodome Distribution | false |
| 18 | Awaydays | - | - | - | $129,261 | 46 | $62,180 | 48.1% | 46 | May 22 | - | Optimum Releasing | false |
| 19 | A Girl Cut in Two | - | - | - | $125,515 | 7 | $13,036 | 10.4% | 5 | May 22 | - | Artificial Eye | false |
| 20 | Sleep Furiously | - | - | - | $121,187 | 12 | $18,906 | 15.6% | 9 | May 29 | - | New Wave Films | false |
| 21 | Everlasting Moments | - | - | - | $115,791 | 7 | $15,177 | 13.1% | 7 | May 22 | - | Icon Film Distribution Australia | false |
| 22 | Fireflies in the Garden 2008 Re-release | - | - | - | $97,167 | 27 | $33,707 | 34.7% | 27 | May 31 | - | The Works UK Distribution | false |
| 23 | O'Horten | - | - | - | $70,678 | 9 | $14,625 | 20.7% | 9 | May 8 | - | Artificial Eye | false |
| 24 | Fermat's Room 2009 Re-release | - | - | - | $48,369 | 5 | $4,792 | 9.9% | 1 | May 29 | - | Revolver Entertainment | false |
| 25 | Blue Eyelids 2009 Re-release | - | - | - | $48,093 | 1 | - | - | - | May 8 | - | Axiom Films | false |
| 26 | Pierrot le Fou 2009 Re-release | - | - | - | $47,138 | 4 | $9,859 | 20.9% | 3 | May 22 | - | British Film Institute (BFI) | false |
| 27 | Sounds Like Teen Spirit | - | - | - | $35,768 | 9 | $12,155 | 34% | 8 | May 8 | - | Warner Music | false |
| 28 | Helen | - | - | - | $34,820 | 6 | $8,551 | 24.6% | 6 | May 1 | - | New Wave Films | false |
| 29 | Fugitive Pieces | - | - | - | $22,182 | 6 | $5,407 | 24.4% | 6 | May 29 | - | Soda Pictures | false |
| 30 | Little Ashes | - | - | - | $19,429 | 4 | $7,450 | 38.3% | 4 | May 8 | - | - | false |
| 31 | Sarvam | - | - | - | $16,903 | 7 | $16,903 | 100% | 7 | May 15 | - | Ayngaran International | false |
| 32 | Objectified | - | - | - | $7,185 | 1 | $7,185 | 100% | 1 | May 22 | - | - | false |
| 33 | French Film | - | - | - | $6,478 | 3 | $3,161 | 48.8% | 3 | May 15 | - | Vertigo Films | false |
| 34 | Momma's Man | - | - | - | $3,141 | 4 | $3,141 | 100% | 4 | May 8 | - | Diffusion Pictures | false |
| 35 | Delta | - | - | - | $2,824 | 2 | $2,824 | 100% | 2 | May 8 | - | ICA Films | false |
| 36 | Funuke: Show Some Love, You Losers! | - | - | - | $713 | 1 | $713 | 100% | 1 | May 1 | - | Third Window Films | false |
| 37 | Louise Bourgeois | - | - | - | $578 | 1 | $578 | 100% | 1 | May 22 | - | Revolver Entertainment | false |
