| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Star Trek | - | - | - | $29,186,820 | 499 | $35,392,062 | May 8 | Paramount Pictures International | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $25,797,004 | 488 | $26,884,047 | Apr 29 | 20th Century Fox International | false |
| 3 | Angels & Demons | - | - | - | $23,225,135 | 512 | $30,726,140 | May 14 | Sony Pictures Releasing | false |
| 4 | Night at the Museum: Battle of the Smithsonian | - | - | - | $19,632,929 | 520 | $32,825,190 | May 21 | 20th Century Fox International | false |
| 5 | Hannah Montana: The Movie | - | - | - | $12,312,503 | 449 | $13,937,675 | May 1 | Walt Disney Pictures | false |
| 6 | Coraline | - | - | - | $10,174,676 | 440 | $12,193,282 | May 8 | Universal Pictures International (UPI) | false |
| 7 | Ghosts of Girlfriends Past | - | - | - | $6,596,665 | 382 | $6,859,122 | May 1 | Entertainment Film Distributors | false |
| 8 | Monsters vs. Aliens | - | - | - | $5,574,303 | 520 | $34,956,968 | Apr 3 | Paramount Pictures International | false |
| 9 | State of Play | - | - | - | $5,191,426 | 398 | $9,206,492 | Apr 24 | Universal Pictures International (UPI) | false |
| 10 | Slumdog Millionaire | - | - | - | $4,108,490 | 449 | $52,213,042 | Jan 9 | Pathé | false |
| 11 | Fighting | - | - | - | $3,163,551 | 293 | $3,341,473 | May 15 | Universal Pictures International (UPI) | false |
| 12 | Drag Me to Hell | - | - | - | $3,087,393 | 408 | $10,503,062 | May 29 | Lionsgate | false |
| 13 | 17 Again | - | - | - | $2,504,976 | 425 | $18,363,139 | Apr 10 | Entertainment Film Distributors | false |
| 14 | I Love You, Man | - | - | - | $2,135,445 | 339 | $6,838,762 | Apr 17 | Paramount Pictures International | false |
| 15 | Fast & Furious | - | - | - | $1,980,118 | 430 | $20,546,785 | Apr 10 | Universal Pictures International (UPI) | false |
| 16 | In the Loop | - | - | - | $1,415,352 | 151 | $3,545,746 | Apr 17 | Optimum Releasing | false |
| 17 | The Boat That Rocked | - | - | - | $1,049,184 | 462 | $10,125,727 | Apr 1 | Universal Pictures International (UPI) | false |
| 18 | Tormented | - | - | - | $1,033,909 | 234 | $1,147,307 | May 22 | Warner Bros. | false |
| 19 | The Young Victoria | - | - | - | $728,475 | 403 | $8,179,212 | Mar 6 | Momentum Pictures | false |
| 20 | Is Anybody There? | - | - | - | $648,514 | 96 | $768,921 | May 1 | Optimum Releasing | false |
| 21 | Marley & Me | - | - | - | $644,046 | 484 | $23,286,860 | Mar 11 | 20th Century Fox International | false |
| 22 | The Uninvited | - | - | - | $642,803 | 219 | $1,487,818 | Apr 24 | Paramount Pictures International | false |
| 23 | Synecdoche, New York | - | - | - | $605,397 | 40 | $875,104 | May 15 | Revolver Entertainment | false |
| 24 | Chéri | - | - | - | $585,995 | 81 | $673,008 | May 8 | Warner Bros. | false |
| 25 | 12 Rounds | - | - | - | $528,886 | 300 | $1,187,641 | May 27 | 20th Century Fox International | false |
| 26 | Race to Witch Mountain | - | - | - | $393,168 | 412 | $4,180,119 | Apr 10 | Walt Disney Pictures | false |
| 27 | The Damned United | - | - | - | $384,255 | 240 | $3,582,592 | Mar 27 | Sony Pictures Releasing | false |
| 28 | Gran Torino | - | - | - | $370,182 | 311 | $13,739,813 | Feb 20 | Warner Bros. | false |
| 29 | Knowing | - | - | - | $358,144 | 391 | $10,342,959 | Mar 25 | Entertainment One | false |
| 30 | Watchmen | - | - | - | $351,404 | 418 | $13,610,059 | Mar 6 | Paramount Pictures International | false |
| 31 | Observe and Report | - | - | - | $296,649 | 263 | $1,025,086 | Apr 24 | Warner Bros. | false |
| 32 | Hotel for Dogs | - | - | - | $286,823 | 435 | $10,814,090 | Feb 13 | Paramount Pictures International | false |
| 33 | Let the Right One In | - | - | - | $282,711 | 95 | $1,830,884 | Apr 10 | Momentum Pictures | false |
| 34 | Obsessed | - | - | - | $249,784 | 149 | $854,917 | May 29 | Sony Pictures Releasing | false |
| 35 | Jonas Brothers: The 3D Concert Experience | - | - | - | $189,445 | 169 | $409,245 | May 29 | Walt Disney Pictures | false |
| 36 | Crank: High Voltage | - | - | - | $167,868 | 319 | $1,859,343 | Apr 16 | Lionsgate | false |
| 37 | Duplicity | - | - | - | $128,833 | 356 | $4,383,941 | Mar 20 | Universal Pictures International (UPI) | false |
| 38 | Munde U.K. De | - | - | - | $125,521 | 7 | $307,106 | May 8 | Tip Top Entertainment (TTE) | false |
| 39 | Fifty Dead Men Walking | - | - | - | $116,213 | 80 | $641,867 | Apr 10 | Metrodome Distribution | false |
| 40 | Awaydays | - | - | - | $112,194 | 46 | $129,261 | May 22 | Optimum Releasing | false |
| 41 | Encounters at the End of the World | - | - | - | $104,875 | 13 | $236,908 | Apr 24 | Revolver Entertainment | false |
| 42 | Shifty | - | - | - | $84,985 | 51 | $244,579 | Apr 24 | Metrodome Distribution | false |
| 43 | Madagascar: Escape 2 Africa | - | - | - | $53,204 | 546 | $35,471,617 | Dec 5 | Paramount Pictures International | false |
| 44 | The Age of Stupid | - | - | - | $43,840 | 20 | $310,829 | Mar 20 | - | false |
| 45 | The Secret of Moonacre | - | - | - | $38,907 | 373 | $1,437,637 | Feb 6 | Warner Bros. | false |
| 46 | Mark of an Angel | - | - | - | $34,545 | 13 | $130,793 | May 22 | Metrodome Distribution | false |
| 47 | O'Horten | - | - | - | $33,767 | 9 | $70,678 | May 8 | Artificial Eye | false |
| 48 | Sounds Like Teen Spirit | - | - | - | $31,608 | 9 | $35,768 | May 8 | Warner Music | false |
| 49 | The Haunting in Connecticut | - | - | - | $26,104 | 314 | $6,191,957 | Mar 27 | Entertainment Film Distributors | false |
| 50 | A Summer in Genoa | - | - | - | $25,629 | 13 | $199,714 | Mar 27 | Metrodome Distribution | false |
| 51 | Helen | - | - | - | $22,897 | 6 | $34,820 | May 1 | New Wave Films | false |
| 52 | Little Ashes | - | - | - | $19,429 | 4 | $19,429 | May 8 | - | false |
| 53 | Good | - | - | - | $19,059 | 14 | $89,539 | Apr 17 | Lionsgate | false |
| 54 | Sleep Furiously | - | - | - | $18,906 | 12 | $121,187 | May 29 | New Wave Films | false |
| 55 | Sarvam | - | - | - | $16,903 | 7 | $16,903 | May 15 | Ayngaran International | false |
| 56 | Everlasting Moments | - | - | - | $15,177 | 7 | $115,791 | May 22 | Icon Film Distribution Australia | false |
| 57 | A Girl Cut in Two | - | - | - | $13,036 | 7 | $125,515 | May 22 | Artificial Eye | false |
| 58 | Mini Punjab | - | - | - | $10,354 | 8 | $63,902 | Apr 17 | - | false |
| 59 | Pierrot le Fou 2009 Re-release | - | - | - | $9,859 | 4 | $47,138 | May 22 | British Film Institute (BFI) | false |
| 60 | Objectified | - | - | - | $7,185 | 1 | $7,185 | May 22 | - | false |
| 61 | Under the Sea 3D | - | - | - | $6,843 | 3 | $345,798 | Feb 13 | IMAX | false |
| 62 | French Film | - | - | - | $6,478 | 3 | $6,478 | May 15 | Vertigo Films | false |
| 63 | Fugitive Pieces | - | - | - | $5,407 | 6 | $22,182 | May 29 | Soda Pictures | false |
| 64 | Fermat's Room 2009 Re-release | - | - | - | $4,792 | 5 | $48,369 | May 29 | Revolver Entertainment | false |
| 65 | From Russia with Love 2009 Re-release | - | - | - | $3,874 | 1 | $11,281 | Apr 24 | Park Circus | false |
| 66 | Waveriders | - | - | - | $3,154 | 15 | $142,878 | Apr 3 | Element Films | false |
| 67 | Momma's Man | - | - | - | $3,141 | 4 | $3,141 | May 8 | Diffusion Pictures | false |
| 68 | The Class | - | - | - | $2,825 | 35 | $1,433,912 | Feb 27 | Artificial Eye | false |
| 69 | Delta | - | - | - | $2,824 | 2 | $2,824 | May 8 | ICA Films | false |
| 70 | Bolt | - | - | - | $1,944 | 570 | $26,755,584 | Feb 13 | Walt Disney Pictures | false |
| 71 | Funuke: Show Some Love, You Losers! | - | - | - | $713 | 1 | $713 | May 1 | Third Window Films | false |
| 72 | Louise Bourgeois | - | - | - | $578 | 1 | $578 | May 22 | Revolver Entertainment | false |
