| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $120,003 | 4 | $202,781 | May 15 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $42,228 | 4 | $42,228 | May 1 | 20th Century Fox International | false |
| 3 | Star Trek | - | - | - | $39,357 | 4 | $42,027 | May 8 | United International Pictures | false |
| 4 | 17 Again | - | - | - | $33,122 | 2 | $57,717 | Apr 24 | Warner Bros. | false |
| 5 | Night at the Museum: Battle of the Smithsonian | - | - | - | $32,756 | 5 | $84,423 | May 22 | 20th Century Fox International | false |
| 6 | Coraline | - | - | - | $23,927 | 1 | $40,402 | May 15 | United International Pictures | false |
| 7 | Fast & Furious | - | - | - | $21,222 | 7 | $165,730 | Apr 10 | United International Pictures | false |
| 8 | Observe and Report | - | - | - | $15,331 | 2 | $15,331 | May 8 | Warner Bros. | false |
| 9 | I Love You, Man | - | - | - | $14,879 | 3 | $22,986 | Apr 24 | United International Pictures | false |
| 10 | Taken | - | - | - | $13,140 | 2 | $13,140 | May 1 | - | false |
| 11 | Monsters vs. Aliens | - | - | - | $11,616 | 7 | $138,992 | Apr 3 | United International Pictures | false |
| 12 | The Last House on the Left | - | - | - | $11,235 | 2 | $23,287 | May 22 | United International Pictures | false |
| 13 | The Boat That Rocked | - | - | - | $9,761 | 3 | $9,761 | May 1 | United International Pictures | false |
| 14 | Ghosts of Girlfriends Past | - | - | - | $7,258 | 3 | $59,644 | May 29 | Warner Bros. | false |
| 15 | Dark Planet: Rebellion | - | - | - | $6,175 | 3 | $15,949 | Apr 24 | - | false |
| 16 | Slumdog Millionaire | - | - | - | $6,171 | 2 | $129,599 | Mar 13 | - | false |
| 17 | State of Play | - | - | - | $3,225 | 1 | $22,802 | May 29 | United International Pictures | false |
| 18 | Crank: High Voltage | - | - | - | $2,364 | 3 | $49,777 | Apr 17 | - | false |
| 19 | New in Town | - | - | - | $1,823 | 2 | $17,239 | Apr 17 | - | false |
| 20 | Choke | - | - | - | $1,346 | 1 | $1,346 | May 15 | - | false |
| 21 | Knowing | - | - | - | $798 | 2 | $50,844 | Apr 3 | - | false |
