| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | X-Men Origins: Wolverine | - | - | - | $635,126 | 40 | $636,910 | Apr 30 | 20th Century Fox International | false |
| 2 | Hannah Montana: The Movie | - | - | - | $453,939 | 37 | $480,266 | May 8 | Walt Disney Pictures | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $424,156 | 40 | $764,477 | May 22 | 20th Century Fox International | false |
| 4 | Angels & Demons | - | - | - | $419,593 | 27 | $543,396 | May 15 | Sony Pictures Releasing | false |
| 5 | Coraline | - | - | - | $261,989 | 31 | $261,989 | Apr 30 | United International Pictures | false |
| 6 | 17 Again | - | - | - | $140,797 | 14 | $175,666 | May 15 | Importadora El Rosado | false |
| 7 | Star Trek | - | - | - | $125,886 | 20 | $125,886 | May 8 | United International Pictures | false |
| 8 | Fast & Furious | - | - | - | $90,798 | 40 | $249,250 | May 29 | United International Pictures | false |
| 9 | Earth | - | - | - | $78,895 | 15 | $181,924 | Apr 24 | Walt Disney Pictures | false |
| 10 | Paul Blart: Mall Cop | - | - | - | $72,601 | 23 | $158,482 | Apr 24 | Sony Pictures Releasing | false |
| 11 | Friday the 13th | - | - | - | $67,085 | 24 | $162,369 | Apr 23 | United International Pictures | false |
| 12 | Space Chimps | - | - | - | $29,274 | 15 | $78,587 | May 29 | - | false |
| 13 | Race to Witch Mountain | - | - | - | $27,048 | 32 | $609,549 | Mar 27 | Walt Disney Pictures | false |
| 14 | Dragonball Evolution | - | - | - | $20,162 | 26 | $384,761 | Apr 9 | 20th Century Fox International | false |
| 15 | He's Just Not That Into You | - | - | - | $20,077 | 10 | $67,617 | May 29 | Importadora El Rosado | false |
| 16 | Changeling | - | - | - | $10,705 | 16 | $59,124 | Apr 17 | United International Pictures | false |
| 17 | Confessions of a Shopaholic | - | - | - | $9,657 | 19 | $154,769 | Apr 9 | Walt Disney Pictures | false |
| 18 | Monsters vs. Aliens | - | - | - | $7,141 | 39 | $501,219 | Apr 3 | United International Pictures | false |
| 19 | The International | - | - | - | $6,481 | 16 | $71,153 | Apr 17 | Sony Pictures Releasing | false |
| 20 | Frost/Nixon | - | - | - | $5,583 | 6 | $5,583 | May 15 | United International Pictures | false |
| 21 | Milk | - | - | - | $2,785 | 2 | $4,270 | May 22 | United International Pictures | false |
