| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $1,639,023 | 73 | $2,211,285 | May 14 | Sony Pictures Releasing | false |
| 2 | Hannah Montana: The Movie | - | - | - | $960,593 | 40 | $1,056,206 | Apr 30 | Walt Disney Pictures | false |
| 3 | X-Men Origins: Wolverine | - | - | - | $940,236 | 64 | $993,660 | Apr 30 | 20th Century Fox International | false |
| 4 | Night at the Museum: Battle of the Smithsonian | - | - | - | $829,981 | 71 | $1,381,208 | May 21 | 20th Century Fox International | false |
| 5 | Knowing | - | - | - | $319,588 | 33 | $715,344 | May 21 | - | false |
| 6 | Fast & Furious | - | - | - | $312,475 | 32 | $344,211 | May 7 | United International Pictures | false |
| 7 | Star Trek | - | - | - | $247,840 | 30 | $273,992 | May 7 | United International Pictures | false |
| 8 | Earth | - | - | - | $235,608 | 20 | $372,880 | Apr 22 | Walt Disney Pictures | false |
| 9 | Monsters vs. Aliens | - | - | - | $206,949 | 79 | $1,036,375 | Apr 2 | United International Pictures | false |
| 10 | Race to Witch Mountain | - | - | - | $205,554 | 36 | $674,840 | Apr 9 | Walt Disney Pictures | false |
| 11 | Vicky Cristina Barcelona | - | - | - | $184,414 | 20 | $220,130 | Apr 30 | - | false |
| 12 | The Unborn | - | - | - | $161,156 | 29 | $344,528 | Apr 16 | United International Pictures | false |
| 13 | 17 Again | - | - | - | $75,381 | 22 | $136,867 | Apr 23 | Warner Bros. | false |
| 14 | Ghosts of Girlfriends Past | - | - | - | $74,508 | 17 | $85,301 | May 14 | Warner Bros. | false |
| 15 | Paris | - | - | - | $59,877 | 5 | $90,990 | May 7 | - | false |
| 16 | Gran Torino | - | - | - | $56,627 | 15 | $356,118 | Mar 19 | Warner Bros. | false |
| 17 | Slumdog Millionaire | - | - | - | $41,781 | 21 | $764,404 | Feb 19 | Bazuca Films | false |
| 18 | Duplicity | - | - | - | $40,821 | 21 | $144,527 | May 28 | United International Pictures | false |
| 19 | The Wrestler | - | - | - | $29,536 | 14 | $71,088 | Apr 23 | - | false |
| 20 | Paul Blart: Mall Cop | - | - | - | $24,819 | 25 | $69,509 | Apr 23 | Sony Pictures Releasing | false |
| 21 | Dragonball Evolution | - | - | - | $19,423 | 57 | $357,254 | Apr 9 | 20th Century Fox International | false |
| 22 | Gomorrah | - | - | - | $19,240 | 14 | $39,643 | May 28 | Transeuropa | false |
| 23 | Rogue | - | - | - | $8,687 | 12 | $8,687 | May 7 | - | false |
| 24 | My Mom's New Boyfriend | - | - | - | $5,104 | 4 | $7,120 | May 28 | Andes Films | false |
| 25 | Changeling | - | - | - | $2,114 | 33 | $260,517 | Mar 12 | United International Pictures | false |
| 26 | Death Sentence | - | - | - | $1,255 | 16 | $38,016 | Apr 16 | - | false |
| 27 | Bedtime Stories | - | - | - | $1,039 | 36 | $1,019,509 | Feb 19 | Walt Disney Pictures | false |
| 28 | My Brother is an Only Child | - | - | - | $982 | 1 | $11,752 | Apr 9 | Transeuropa | false |
| 29 | Reincarnation 2009 Re-release | - | - | - | $853 | 7 | $68,087 | Mar 26 | Andes Films | false |
| 30 | Underworld: Rise of the Lycans | - | - | - | $679 | 31 | $316,294 | Mar 19 | Sony Pictures Releasing | false |
| 31 | Confessions of a Shopaholic | - | - | - | $452 | 21 | $106,491 | Mar 26 | Walt Disney Pictures | false |
