| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $2,794,562 | 98 | $4,702,870 | May 13 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $2,033,012 | 100 | $2,342,715 | Apr 29 | 20th Century Fox International | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $1,071,989 | 85 | $2,449,746 | May 20 | 20th Century Fox International | false |
| 4 | Star Trek | - | - | - | $822,279 | 43 | $1,030,703 | May 6 | Universal Pictures International (UPI) | false |
| 5 | 17 Again | - | - | - | $760,891 | 36 | $1,298,598 | May 6 | Kinepolis Film Distribution (KFD) | false |
| 6 | Fast & Furious | - | - | - | $599,558 | 50 | $3,357,800 | Apr 8 | Universal Pictures International (UPI) | false |
| 7 | He's Just Not That Into You | - | - | - | $580,256 | 37 | $1,183,482 | Apr 22 | Paradiso Entertainment | false |
| 8 | Knowing | - | - | - | $500,586 | 58 | $2,700,532 | Apr 1 | Belga Films | false |
| 9 | My Bloody Valentine | - | - | - | $460,786 | 15 | $617,724 | Apr 29 | Kinepolis Film Distribution (KFD) | false |
| 10 | Coco Before Chanel | - | - | - | $391,383 | 32 | $653,020 | Apr 22 | Kinepolis Film Distribution (KFD) | false |
| 11 | Sister Smile | - | - | - | $386,053 | 33 | $585,907 | May 6 | Kinepolis Film Distribution (KFD) | false |
| 12 | Slumdog Millionaire | - | - | - | $336,183 | 40 | $3,794,750 | Jan 14 | Cinéart | false |
| 13 | Monsters vs. Aliens | - | - | - | $316,551 | 96 | $1,796,363 | Apr 1 | Universal Pictures International (UPI) | false |
| 14 | Beverly Hills Chihuahua | - | - | - | $315,420 | 52 | $1,342,050 | Apr 1 | Walt Disney Pictures | false |
| 15 | OSS 117: Lost in Rio | - | - | - | $279,936 | 21 | $768,906 | Apr 15 | Belga Films | false |
| 16 | Incognito | - | - | - | $273,446 | 15 | $312,690 | Apr 29 | Alternative Films | false |
| 17 | The Girl with the Dragon Tattoo | - | - | - | $227,115 | 42 | $604,455 | May 20 | Benelux Film Distributors | false |
| 18 | The Last House on the Left | - | - | - | $209,279 | 27 | $403,733 | Apr 22 | Universal Pictures International (UPI) | false |
| 19 | S&M Judge | - | - | - | $143,557 | 19 | $1,142,211 | Mar 11 | Kinepolis Film Distribution (KFD) | false |
| 20 | In the Electric Mist | - | - | - | $140,285 | 16 | $249,071 | Apr 22 | Benelux Film Distributors | false |
| 21 | Bolt | - | - | - | $124,285 | 98 | $3,284,544 | Feb 11 | Walt Disney Pictures | false |
| 22 | Je l'aimais | - | - | - | $122,654 | 14 | $162,599 | May 6 | - | false |
| 23 | The Boy in the Striped Pajamas | - | - | - | $113,698 | 11 | $135,110 | Apr 29 | Walt Disney Pictures | false |
| 24 | Twilight | - | - | - | $97,385 | 54 | $3,294,541 | Nov 26 | Belga Films | false |
| 25 | Duplicity | - | - | - | $82,432 | 38 | $956,611 | Mar 25 | Universal Pictures International (UPI) | false |
| 26 | Gran Torino | - | - | - | $76,981 | 32 | $1,126,546 | Feb 25 | Warner Bros. | false |
| 27 | The Reader | - | - | - | $75,450 | 25 | $912,785 | Mar 4 | Benelux Film Distributors | false |
| 28 | London River | - | - | - | $66,085 | 12 | $73,176 | Apr 29 | ABC Distribution | false |
| 29 | Make It Happen | - | - | - | $64,730 | 18 | $379,114 | Apr 8 | Benelux Film Distributors | false |
| 30 | The Boat That Rocked | - | - | - | $58,700 | 28 | $84,981 | May 6 | Universal Pictures International (UPI) | false |
| 31 | Safari | - | - | - | $58,430 | 18 | $536,468 | Apr 1 | Alternative Films | false |
| 32 | Hotel for Dogs | - | - | - | $48,922 | 45 | $1,302,755 | Feb 18 | Universal Pictures International (UPI) | false |
| 33 | Chéri | - | - | - | $48,657 | 20 | $264,933 | Apr 8 | Benelux Film Distributors | false |
| 34 | Confessions of a Shopaholic | - | - | - | $41,752 | 52 | $926,725 | Mar 18 | Walt Disney Pictures | false |
| 35 | Watchmen | - | - | - | $36,288 | 52 | $1,223,314 | Mar 4 | Universal Pictures International (UPI) | false |
| 36 | Le missionnaire | - | - | - | $34,179 | 14 | $35,165 | Apr 29 | - | false |
| 37 | Ponyo | - | - | - | $31,317 | 10 | $114,702 | Apr 8 | Cinéart | false |
| 38 | Katanga Business | - | - | - | $27,124 | 7 | $99,263 | Apr 1 | Cinéart | false |
| 39 | Bank Error in Your Favour | - | - | - | $26,454 | 14 | $79,646 | May 27 | Cinéart | false |
| 40 | The Chaser | - | - | - | $23,799 | 5 | $29,740 | May 6 | Cinéart | false |
| 41 | Welcome | - | - | - | $23,290 | 11 | $169,847 | Mar 25 | Cinéart | false |
| 42 | Milk | - | - | - | $21,538 | 17 | $376,401 | Feb 25 | A-Film Distribution | false |
| 43 | The Uninvited | - | - | - | $20,557 | 15 | $164,844 | Apr 15 | Universal Pictures International (UPI) | false |
| 44 | Defiance | - | - | - | $19,776 | 32 | $265,967 | Mar 4 | Kinepolis Film Distribution (KFD) | false |
| 45 | Observe and Report | - | - | - | $17,947 | 6 | $18,243 | May 13 | 20th Century Fox International | false |
| 46 | Linha de Passe | - | - | - | $17,555 | 8 | $45,018 | Apr 15 | Cinéart | false |
| 47 | Celle que j'aime | - | - | - | $17,044 | 7 | $20,111 | Apr 29 | Les Films de l'Elysée | false |
| 48 | The Unborn | - | - | - | $14,814 | 17 | $288,914 | Mar 18 | Universal Pictures International (UPI) | false |
| 49 | Jonas Brothers: The 3D Concert Experience | - | - | - | $12,913 | 12 | $12,913 | May 13 | Walt Disney Pictures | false |
| 50 | Synecdoche, New York | - | - | - | $11,759 | 4 | $19,525 | May 13 | Paradiso Entertainment | false |
| 51 | Frozen River | - | - | - | $11,389 | 4 | $25,850 | Apr 15 | A-Film Distribution | false |
| 52 | Vengeance | - | - | - | $10,397 | 16 | $27,377 | May 27 | - | false |
| 53 | The International | - | - | - | $9,697 | 30 | $355,898 | Mar 11 | Sony Pictures Releasing | false |
| 54 | Inkheart | - | - | - | $9,441 | 14 | $105,975 | Apr 8 | Paradiso Entertainment | false |
| 55 | Romaine 30° Below | - | - | - | $8,703 | 3 | $9,147 | May 13 | Les Films de l'Elysée | false |
| 56 | Food Beware: The French Organic Revolution | - | - | - | $7,645 | 6 | $33,255 | Apr 15 | - | false |
| 57 | Tokyo Sonata | - | - | - | $7,582 | 2 | $14,077 | May 20 | A-Film Distribution | false |
| 58 | The Curious Case of Benjamin Button | - | - | - | $6,141 | 70 | $3,305,657 | Feb 4 | Warner Bros. | false |
| 59 | Che: Part Two | - | - | - | $5,302 | 3 | $20,533 | Apr 22 | Cinéart | false |
| 60 | The True Story of Puss'N Boots | - | - | - | $3,736 | 19 | $78,056 | Apr 1 | - | false |
| 61 | Marley & Me | - | - | - | $3,646 | 50 | $1,107,042 | Mar 11 | 20th Century Fox International | false |
| 62 | Coco | - | - | - | $3,235 | 21 | $905,950 | Mar 18 | Universal Pictures International (UPI) | false |
| 63 | Eden Is West | - | - | - | $2,858 | 3 | $13,973 | May 27 | Alternative Films | false |
| 64 | Dragonball Evolution | - | - | - | $2,288 | 30 | $271,749 | Apr 8 | 20th Century Fox International | false |
| 65 | Red Cliff | - | - | - | $2,198 | 23 | $305,236 | Mar 25 | Belga Films | false |
| 66 | The Fall | - | - | - | $1,948 | 3 | $17,372 | Mar 11 | Paradiso Entertainment | false |
| 67 | Underworld: Rise of the Lycans | - | - | - | $1,825 | 5 | $94,540 | Mar 18 | Sony Pictures Releasing | false |
| 68 | Episode 3: 'Enjoy Poverty' | - | - | - | $1,660 | 2 | $1,660 | May 13 | - | false |
| 69 | Française | - | - | - | $1,052 | 2 | $1,118 | May 6 | - | false |
| 70 | The Visitor | - | - | - | $798 | 1 | $798 | May 20 | - | false |
| 71 | Fighter | - | - | - | $775 | 6 | $819 | Apr 29 | Jekino | false |
| 72 | Jar City | - | - | - | $737 | 2 | $874 | May 6 | - | false |
| 73 | Birdwatchers | - | - | - | $546 | 2 | $3,543 | Mar 4 | ABC Distribution | false |
| 74 | The Girl on the Train | - | - | - | $520 | 12 | $50,998 | Mar 18 | Benelux Film Distributors | false |
| 75 | Princess Lillifee | - | - | - | $377 | 14 | $59,805 | Mar 27 | Walt Disney Pictures | false |
| 76 | Leonera | - | - | - | $38 | 4 | $7,681 | Mar 25 | A-Film Distribution | false |
