| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Angels & Demons | - | - | - | $2,389,799 | 161 | $3,330,559 | May 14 | Sony Pictures Releasing | false |
| 2 | X-Men Origins: Wolverine | - | - | - | $1,636,644 | 112 | $1,725,740 | Apr 30 | 20th Century Fox International | false |
| 3 | Night at the Museum: Battle of the Smithsonian | - | - | - | $1,388,876 | 115 | $2,537,926 | May 21 | 20th Century Fox International | false |
| 4 | The Reader | - | - | - | $475,996 | 35 | $570,036 | May 7 | Pachamama Cine | false |
| 5 | 17 Again | - | - | - | $406,868 | 47 | $421,582 | May 7 | Distribution Company | false |
| 6 | Star Trek | - | - | - | $391,037 | 50 | $403,172 | May 7 | Paramount Pictures International | false |
| 7 | The Unborn | - | - | - | $352,226 | 36 | $776,427 | May 21 | Universal Pictures International (UPI) | false |
| 8 | Duplicity | - | - | - | $351,798 | 41 | $587,482 | Apr 23 | Universal Pictures International (UPI) | false |
| 9 | Race to Witch Mountain | - | - | - | $333,225 | 48 | $966,504 | Apr 9 | Walt Disney Pictures | false |
| 10 | Fast & Furious | - | - | - | $325,900 | 48 | $1,901,922 | Apr 2 | Universal Pictures International (UPI) | false |
| 11 | Earth | - | - | - | $289,919 | 31 | $480,164 | Apr 22 | Walt Disney Pictures | false |
| 12 | Monsters vs. Aliens | - | - | - | $260,748 | 119 | $1,596,237 | Apr 2 | Paramount Pictures International | false |
| 13 | The Accidental Husband | - | - | - | $217,944 | 35 | $225,379 | Apr 30 | Walt Disney Pictures | false |
| 14 | Jonas Brothers: The 3D Concert Experience | - | - | - | $196,762 | 14 | $313,395 | May 22 | Walt Disney Pictures | false |
| 15 | Esperando la carroza 2: Se acabó la fiesta | - | - | - | $170,784 | 88 | $1,287,043 | Apr 2 | Primer Plano Film Group | false |
| 16 | Knowing | - | - | - | $162,736 | 50 | $1,080,098 | Apr 2 | Alfa Films | false |
| 17 | He's Just Not That Into You | - | - | - | $130,438 | 33 | $1,065,060 | Mar 5 | Distribution Company | false |
| 18 | The Class | - | - | - | $123,297 | 21 | $301,798 | Apr 16 | Primer Plano Film Group | false |
| 19 | New in Town | - | - | - | $110,691 | 31 | $262,520 | May 28 | Distribution Company | false |
| 20 | Live! | - | - | - | $86,631 | 23 | $231,368 | Apr 16 | Distribution Company | false |
| 21 | Lorna's Silence | - | - | - | $76,799 | 8 | $91,085 | May 14 | Distribution Company | false |
| 22 | Then She Found Me | - | - | - | $74,960 | 20 | $77,002 | Apr 30 | Distribution Company | false |
| 23 | Dragonball Evolution | - | - | - | $71,397 | 48 | $578,542 | Apr 9 | 20th Century Fox International | false |
| 24 | Gardens in Autumn 2008 Re-release | - | - | - | $69,906 | 7 | $82,676 | Apr 30 | IFA | false |
| 25 | Big Stan | - | - | - | $47,620 | 21 | $102,086 | Apr 23 | Pachamama Cine | false |
| 26 | The Merry Widow | - | - | - | $41,698 | 14 | $151,596 | Apr 16 | Alfa Films | false |
| 27 | Slumdog Millionaire | - | - | - | $27,196 | 47 | $1,523,147 | Feb 12 | Distribution Company | false |
| 28 | The Fish Child | - | - | - | $25,517 | 36 | $152,209 | Apr 9 | Distribution Company | false |
| 29 | Música en espera | - | - | - | $25,464 | 40 | $826,770 | Mar 19 | Distribution Company | false |
| 30 | Blood Appears | - | - | - | $21,421 | 6 | $25,911 | May 14 | - | false |
| 31 | Fireflies in the Garden 2008 Re-release | - | - | - | $15,237 | 14 | $75,443 | Mar 26 | - | false |
| 32 | The Air I Breathe | - | - | - | $15,116 | 9 | $47,777 | Apr 16 | CDI Films | false |
| 33 | Cloud 9 | - | - | - | $13,632 | 6 | $56,116 | Apr 9 | Primer Plano Film Group | false |
| 34 | Days of May | - | - | - | $13,617 | 5 | $17,291 | May 21 | Primer Plano Film Group | false |
| 35 | Chef's Special 2009 Re-release | - | - | - | $13,250 | 13 | $16,498 | May 28 | Alfa Films | false |
| 36 | The Artist | - | - | - | $13,233 | 5 | $26,090 | May 28 | Primer Plano Film Group | false |
| 37 | Luisa | - | - | - | $12,167 | 9 | $14,253 | May 7 | Primer Plano Film Group | false |
| 38 | The International | - | - | - | $10,838 | 30 | $342,598 | Mar 26 | Sony Pictures Releasing | false |
| 39 | Belle toujours 2008 Re-release | - | - | - | $10,691 | 7 | $65,716 | Apr 9 | Impacto Cine | false |
| 40 | Hotel for Dogs | - | - | - | $10,147 | 43 | $633,029 | Feb 19 | Paramount Pictures International | false |
| 41 | The Edge of Heaven | - | - | - | $9,591 | 13 | $155,500 | Mar 19 | Alfa Films | false |
| 42 | A Thousand Years of Good Prayers | - | - | - | $8,030 | 5 | $10,685 | May 21 | Primer Plano Film Group | false |
| 43 | Pa-ra-da | - | - | - | $7,632 | 5 | $7,632 | May 7 | Primer Plano Film Group | false |
| 44 | Manuel de Falla, músico de dos mundos | - | - | - | $6,045 | 7 | $6,045 | Apr 30 | Primer Plano Film Group | false |
| 45 | Gran Torino | - | - | - | $6,036 | 51 | $903,115 | Mar 5 | Warner Bros. | false |
| 46 | Rumba | - | - | - | $3,429 | 9 | $67,362 | Apr 2 | Distribution Company | false |
| 47 | Mundo alas | - | - | - | $3,223 | 8 | $35,429 | Mar 26 | Distribution Company | false |
| 48 | Confessions of a Shopaholic | - | - | - | $2,615 | 46 | $338,497 | Mar 19 | Walt Disney Pictures | false |
| 49 | Coraline | - | - | - | $1,962 | 24 | $141,818 | Mar 12 | Universal Pictures International (UPI) | false |
| 50 | Transporter 3 | - | - | - | $1,484 | 42 | $386,925 | Mar 12 | - | false |
| 51 | Bonneville | - | - | - | $849 | 14 | $54,595 | Mar 26 | Impacto Cine | false |
| 52 | Seven Pounds | - | - | - | $817 | 28 | $263,090 | Feb 26 | Sony Pictures Releasing | false |
| 53 | Paris | - | - | - | $797 | 17 | $212,523 | Mar 12 | Impacto Cine | false |
| 54 | Summer Hours | - | - | - | $730 | 4 | $209,214 | Jan 22 | Alfa Films | false |
| 55 | Gomorrah | - | - | - | $615 | 33 | $254,128 | Mar 12 | Alfa Films | false |
| 56 | Battle in Heaven 2009 Re-release | - | - | - | $564 | 5 | $4,476 | Apr 23 | Primer Plano Film Group | false |
| 57 | Porotos de soja | - | - | - | $302 | 1 | $748 | May 21 | - | false |
| 58 | Push | - | - | - | $290 | 25 | $78,511 | Mar 26 | Alfa Films | false |
| 59 | Watchmen | - | - | - | $151 | 56 | $431,855 | Mar 5 | Paramount Pictures International | false |
