| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | What Happens in Vegas | - | - | - | $116,433 | 7 | $185,919 | May 9 | - | false |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $95,601 | 14 | $162,247 | May 22 | - | false |
| 3 | 21 | - | - | - | $85,093 | 5 | $143,373 | May 16 | - | false |
| 4 | Speed Racer | - | - | - | $83,952 | 11 | $104,241 | May 9 | - | false |
| 5 | Masangeles | - | - | - | $73,904 | 8 | $82,150 | May 2 | - | false |
| 6 | Iron Man | - | - | - | $67,493 | 9 | $73,896 | May 2 | - | false |
| 7 | P.S. I Love You | - | - | - | $50,779 | 5 | $90,287 | Apr 25 | - | false |
| 8 | Eastern Promises | - | - | - | $30,776 | 4 | $37,132 | May 9 | - | false |
| 9 | Shattered | - | - | - | $19,428 | 5 | $32,636 | Apr 25 | - | false |
| 10 | Caramel | - | - | - | $18,944 | 3 | $45,991 | May 23 | - | false |
| 11 | Vantage Point | - | - | - | $18,037 | 6 | $91,534 | Apr 4 | - | false |
| 12 | Kill Them All | - | - | - | $15,387 | 8 | $70,162 | Apr 11 | - | false |
| 13 | Hit | - | - | - | $15,355 | 7 | $129,589 | Mar 14 | - | false |
| 14 | The Kite Runner | - | - | - | $14,229 | 1 | $24,214 | Apr 18 | - | false |
| 15 | I Do: How to Get Married and Stay Single | - | - | - | $8,357 | 2 | $22,248 | Apr 11 | - | false |
| 16 | The Spiderwick Chronicles | - | - | - | $8,306 | 5 | $43,959 | Mar 14 | - | false |
| 17 | I Could Never Be Your Woman | - | - | - | $7,843 | 4 | $56,516 | Apr 18 | - | false |
| 18 | August Rush | - | - | - | $6,515 | 1 | $23,133 | May 16 | - | false |
| 19 | Horton Hears a Who! | - | - | - | $6,182 | 9 | $114,107 | Mar 14 | - | false |
| 20 | Shutter | - | - | - | $4,790 | 3 | $26,832 | Apr 18 | - | false |
| 21 | Fool's Gold | - | - | - | $4,774 | 5 | $24,881 | Apr 18 | - | false |
| 22 | 1408 | - | - | - | $4,691 | 4 | $27,503 | Apr 4 | - | false |
| 23 | Vitus | - | - | - | $4,075 | 1 | $6,431 | May 23 | - | false |
| 24 | Explosive Brigade: Pirate Mission | - | - | - | $4,002 | 4 | $4,002 | May 16 | - | false |
| 25 | My Best Friend | - | - | - | $3,641 | 3 | $34,413 | Mar 28 | - | false |
| 26 | Bratz | - | - | - | $2,796 | 5 | $24,815 | Mar 21 | - | false |
| 27 | Angel-A | - | - | - | $2,759 | 2 | $6,888 | May 30 | - | false |
| 28 | The Water Horse | - | - | - | $2,114 | 8 | $89,068 | Feb 15 | - | false |
| 29 | Fierro | - | - | - | $2,043 | 4 | $2,107 | May 2 | - | false |
| 30 | D.F. (destino final) | - | - | - | $1,999 | 2 | $28,571 | May 30 | - | false |
| 31 | Untraceable | - | - | - | $1,526 | 5 | $72,607 | Mar 7 | - | false |
| 32 | Lonely Hearts | - | - | - | $941 | 4 | $21,067 | Apr 4 | - | false |
| 33 | 10,000 BC | - | - | - | $765 | 8 | $108,127 | Mar 21 | - | false |
| 34 | After the Wedding | - | - | - | $645 | 2 | $16,412 | Mar 7 | - | false |
