| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man | - | - | - | $2,536,090 | 73 | $2,731,097 | May 1 | Paramount Pictures International | false |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $2,476,787 | 114 | $3,873,372 | May 22 | Paramount Pictures International | false |
| 3 | What Happens in Vegas | - | - | - | $773,237 | 50 | $898,314 | May 8 | 20th Century Fox International | false |
| 4 | Made of Honor | - | - | - | $530,918 | 48 | $550,172 | May 1 | Sony Pictures Releasing | false |
| 5 | Second Hand Wedding | - | - | - | $528,063 | 55 | $1,306,250 | May 15 | Metropolis Films | false |
| 6 | Horton Hears a Who! | - | - | - | $450,075 | 90 | $1,809,758 | Apr 17 | 20th Century Fox International | false |
| 7 | The Painted Veil | - | - | - | $282,818 | 15 | $510,782 | Apr 24 | Paramount Pictures International | false |
| 8 | 21 | - | - | - | $257,332 | 55 | $655,477 | May 29 | Sony Pictures Releasing | false |
| 9 | Nim's Island | - | - | - | $244,486 | 50 | $809,726 | Apr 17 | Paramount Pictures International | false |
| 10 | The Spiderwick Chronicles | - | - | - | $227,986 | 65 | $1,025,914 | Apr 10 | Paramount Pictures International | false |
| 11 | Prom Night | - | - | - | $219,948 | 34 | $256,505 | May 15 | Sony Pictures Releasing | false |
| 12 | Lars and the Real Girl | - | - | - | $202,595 | 20 | $496,363 | Apr 10 | Rialto Distribution | false |
| 13 | Superhero Movie | - | - | - | $189,060 | 42 | $521,813 | Apr 24 | Roadshow Films | false |
| 14 | I'm Not There | - | - | - | $143,083 | 17 | $58 | May 8 | Hoyts Distribution | false |
| 15 | How About You | - | - | - | $142,732 | 26 | $157,504 | May 8 | Hopscotch Films | false |
| 16 | Dan in Real Life | - | - | - | $137,640 | 49 | $138,843 | May 1 | Hoyts Distribution | false |
| 17 | Untraceable | - | - | - | $134,871 | 32 | $157,084 | May 15 | Paramount Pictures International | false |
| 18 | The Bucket List | - | - | - | $110,453 | 43 | $1,348,550 | Feb 21 | Warner Bros. | false |
| 19 | Street Kings | - | - | - | $105,295 | 35 | $493,891 | Apr 17 | 20th Century Fox International | false |
| 20 | The Diving Bell and the Butterfly | - | - | - | $101,855 | 26 | $284,061 | May 22 | Hoyts Distribution | false |
| 21 | U2 3D | - | - | - | $96,544 | 4 | $133,449 | Apr 24 | Roadshow Films | false |
| 22 | St. Trinian's | - | - | - | $79,660 | 57 | $426,771 | Apr 17 | Sony Pictures Releasing | false |
| 23 | Step Up 2: The Streets | - | - | - | $78,906 | 33 | $1,447,792 | Mar 13 | Paramount Pictures International | false |
| 24 | Shine a Light | - | - | - | $72,733 | 4 | $259,054 | May 29 | 20th Century Fox International | false |
| 25 | Happy-Go-Lucky | - | - | - | $62,971 | 25 | $293,681 | May 29 | Rialto Distribution | false |
| 26 | Two Days in Paris | - | - | - | $60,368 | 22 | $434,413 | Mar 20 | Hopscotch Films | false |
| 27 | Hunting and Gathering | - | - | - | $57,541 | 6 | $129,800 | Apr 17 | Palace Films | false |
| 28 | Mama's Boy | - | - | - | $51,828 | 23 | $51,828 | May 15 | Rialto Distribution | false |
| 29 | Sydney White | - | - | - | $42,519 | 44 | $126,659 | Apr 24 | Hoyts Distribution | false |
| 30 | Semi-Pro | - | - | - | $42,418 | 43 | $542,335 | Apr 10 | Roadshow Films | false |
| 31 | College Road Trip | - | - | - | $37,460 | 37 | $223,199 | Apr 18 | Walt Disney Pictures | false |
| 32 | In the Shadow of the Moon | - | - | - | $32,845 | 10 | $115,902 | May 22 | Madman Entertainment | false |
| 33 | Definitely, Maybe | - | - | - | $27,511 | 40 | $528,504 | Apr 3 | Paramount Pictures International | false |
| 34 | Death at a Funeral | - | - | - | $27,323 | 82 | $2,632,381 | Jan 10 | Hoyts Distribution | false |
| 35 | No Country for Old Men | - | - | - | $25,550 | 27 | $793,279 | Jan 31 | Paramount Pictures International | false |
| 36 | Music Within | - | - | - | $20,437 | 7 | $33,494 | Apr 24 | Rialto Distribution | false |
| 37 | Gone Baby Gone | - | - | - | $17,130 | 19 | $220,914 | Mar 27 | Walt Disney Pictures | false |
| 38 | There Will Be Blood | - | - | - | $11,771 | 18 | $352,416 | Feb 14 | Walt Disney Pictures | false |
| 39 | 3:10 to Yuma | - | - | - | $11,593 | 56 | $350,931 | Mar 20 | Hoyts Distribution | false |
| 40 | Once | - | - | - | $11,311 | 28 | $613,196 | Dec 6 | Hoyts Distribution | false |
| 41 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $11,078 | 2 | $142,442 | Mar 20 | Walt Disney Pictures | false |
| 42 | Leatherheads | - | - | - | $10,164 | 14 | $23,040 | May 29 | Paramount Pictures International | false |
| 43 | 4 | - | - | - | $10,013 | 25 | $151,980 | May 15 | Arkles Entertainment | false |
| 44 | How She Move | - | - | - | $9,513 | 32 | $310,723 | Apr 10 | Paramount Pictures International | false |
| 45 | The War on Democracy | - | - | - | $8,135 | 5 | $38,103 | Mar 6 | Hopscotch Films | false |
| 46 | Across the Universe | - | - | - | $7,505 | 4 | $50,705 | Apr 17 | Sony Pictures Releasing | false |
| 47 | Bonneville | - | - | - | $4,222 | 28 | $70,390 | Mar 27 | Dendy Films | false |
| 48 | Run Fatboy Run | - | - | - | $3,615 | 55 | $632,562 | Mar 13 | Roadshow Films | false |
| 49 | Bella | - | - | - | $3,583 | 7 | $101,655 | Nov 22 | Hopscotch Films | false |
| 50 | P.S. I Love You | - | - | - | $3,539 | 54 | $404,108 | Feb 28 | Hoyts Distribution | false |
| 51 | 10,000 BC | - | - | - | $2,533 | 47 | $1,068,677 | Mar 6 | Warner Bros. | false |
| 52 | Molière | - | - | - | $2,141 | 15 | $61,188 | Feb 28 | Hopscotch Films | false |
| 53 | Lady Chatterley | - | - | - | $1,853 | 4 | $30,389 | Feb 28 | Hopscotch Films | false |
| 54 | Rambo | - | - | - | $1,782 | 37 | $404,766 | Mar 27 | Sony Pictures Releasing | false |
| 55 | Alvin and the Chipmunks | - | - | - | $975 | 74 | $2,362,134 | Jan 1 | 20th Century Fox International | false |
| 56 | Never Back Down | - | - | - | $892 | 41 | $337,430 | Apr 3 | Roadshow Films | false |
| 57 | 27 Dresses | - | - | - | $591 | 50 | $1,091,250 | Feb 14 | 20th Century Fox International | false |
| 58 | Deep Water | - | - | - | $35 | 13 | $86,403 | Sep 27 | Hopscotch Films | false |
