| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $3,133,301 | 133 | $6,858,076 | May 22 | Universal Pictures International (UPI) | false |
| 2 | What Happens in Vegas | - | - | - | $2,664,642 | 93 | $4,169,150 | May 8 | Warner Bros. | false |
| 3 | Iron Man | - | - | - | $1,865,372 | 75 | $2,103,537 | May 1 | Universal Pictures International (UPI) | false |
| 4 | Dunya & Desie | - | - | - | $993,799 | 80 | $2,173,370 | Apr 17 | Independent Films | false |
| 5 | Taken | - | - | - | $654,190 | 35 | $1,003,046 | May 1 | Independent Films | false |
| 6 | Fool's Gold | - | - | - | $650,224 | 39 | $813,348 | May 1 | Warner Bros. | false |
| 7 | Into the Wild | - | - | - | $493,289 | 23 | $1,434,924 | Apr 24 | A-Film Distribution | false |
| 8 | Morrison krijgt een zusje | - | - | - | $345,412 | 85 | $670,833 | Apr 23 | Warner Bros. | false |
| 9 | Winx Club: The Secret of the Lost Kingdom | - | - | - | $329,933 | 110 | $704,794 | Apr 16 | Independent Films | false |
| 10 | Summer Heat | - | - | - | $320,443 | 88 | $3,283,980 | Mar 20 | Independent Films | false |
| 11 | Meet the Spartans | - | - | - | $277,679 | 50 | $589,514 | Apr 24 | Warner Bros. | false |
| 12 | Horton Hears a Who! | - | - | - | $250,661 | 162 | $2,072,468 | Mar 19 | Warner Bros. | false |
| 13 | Street Kings | - | - | - | $219,552 | 51 | $733,480 | Apr 17 | Warner Bros. | false |
| 14 | The Bucket List | - | - | - | $218,937 | 35 | $1,377,573 | Mar 27 | Warner Bros. | false |
| 15 | Happy-Go-Lucky | - | - | - | $212,552 | 21 | $412,001 | May 15 | RCV Film Distribution | false |
| 16 | Vantage Point | - | - | - | $199,406 | 51 | $1,087,846 | Apr 10 | Sony Pictures Releasing | false |
| 17 | The Kite Runner | - | - | - | $165,466 | 88 | $7,357,076 | Jan 10 | Universal Pictures International (UPI) | false |
| 18 | Over Her Dead Body | - | - | - | $159,717 | 20 | $284,545 | May 22 | RCV Film Distribution | false |
| 19 | Be Kind Rewind | - | - | - | $148,224 | 16 | $194,963 | May 15 | A-Film Distribution | false |
| 20 | Speed Racer | - | - | - | $139,419 | 88 | $152,146 | May 7 | Warner Bros. | false |
| 21 | Dragon Hunters | - | - | - | $139,049 | 61 | $264,633 | Apr 23 | Independent Films | false |
| 22 | Doomsday | - | - | - | $96,333 | 35 | $253,330 | Apr 24 | RCV Film Distribution | false |
| 23 | The Ruins | - | - | - | $77,671 | 25 | $329,672 | Apr 17 | Universal Pictures International (UPI) | false |
| 24 | Alvin and the Chipmunks | - | - | - | $74,971 | 95 | $4,303,169 | Feb 6 | 20th Century Fox International | false |
| 25 | The Orphanage | - | - | - | $57,358 | 14 | $111,421 | May 22 | A-Film Distribution | false |
| 26 | Paris | - | - | - | $42,314 | 10 | $45,159 | May 15 | Cinéart | false |
| 27 | All the Boys Love Mandy Lane | - | - | - | $41,992 | 15 | $135,850 | May 29 | Moonlight Films | false |
| 28 | Elite Squad | - | - | - | $40,862 | 15 | $93,542 | May 22 | Benelux Film Distributors | false |
| 29 | Leatherheads | - | - | - | $29,712 | 15 | $64,688 | May 29 | Universal Pictures International (UPI) | false |
| 30 | Untraceable | - | - | - | $28,466 | 35 | $871,965 | Mar 20 | RCV Film Distribution | false |
| 31 | The Eye | - | - | - | $28,066 | 40 | $648,811 | Apr 3 | RCV Film Distribution | false |
| 32 | The Spiderwick Chronicles | - | - | - | $24,005 | 107 | $940,386 | Mar 12 | Universal Pictures International (UPI) | false |
| 33 | No Country for Old Men | - | - | - | $20,631 | 35 | $2,160,513 | Feb 14 | Universal Pictures International (UPI) | false |
| 34 | Funny Games | - | - | - | $19,739 | 14 | $66,644 | May 29 | Cinéart | false |
| 35 | Silk | - | - | - | $12,589 | 14 | $12,589 | May 1 | Benelux Film Distributors | false |
| 36 | Flight of the Red Balloon | - | - | - | $12,090 | 5 | $12,090 | May 1 | Filmmuseum Distributie | false |
| 37 | The Secret of the Grain | - | - | - | $8,802 | 6 | $228,116 | Apr 17 | Cinéart | false |
| 38 | Shall We Kiss? | - | - | - | $7,228 | 9 | $7,228 | May 8 | Cinemien | false |
| 39 | The Fall | - | - | - | $4,910 | 5 | $4,910 | May 1 | Paradiso Entertainment | false |
