| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | What Happens in Vegas | - | - | - | $168,070 | 3 | $268,518 | May 9 | Universal Pictures International (UPI) | false |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $126,223 | 5 | $303,200 | May 22 | Universal Pictures International (UPI) | false |
| 3 | Iron Man | - | - | - | $107,381 | 3 | $126,835 | May 1 | Universal Pictures International (UPI) | false |
| 4 | 21 | - | - | - | $68,200 | 3 | $219,076 | Apr 18 | Universal Pictures International (UPI) | false |
| 5 | Fool's Gold | - | - | - | $35,701 | 3 | $130,928 | Apr 11 | Universal Pictures International (UPI) | false |
| 6 | Leatherheads | - | - | - | $30,550 | 1 | $60,079 | Apr 25 | Universal Pictures International (UPI) | false |
| 7 | Deception | - | - | - | $27,045 | 1 | $29,422 | May 2 | ACME | false |
| 8 | The Orphanage | - | - | - | $24,441 | 11 | $37,268 | Apr 25 | ACME | false |
| 9 | Drillbit Taylor | - | - | - | $19,079 | 1 | $76,888 | Apr 4 | Universal Pictures International (UPI) | false |
| 10 | Female Agents | - | - | - | $15,920 | 1 | $17,519 | May 9 | ACME | false |
| 11 | Amatieris | - | - | - | $14,484 | 1 | $64,023 | Apr 11 | Red Cats Film Studio | false |
| 12 | Street Kings | - | - | - | $13,281 | 2 | $50,010 | Apr 18 | Universal Pictures International (UPI) | false |
| 13 | Speed Racer | - | - | - | $13,135 | 3 | $15,365 | May 16 | Universal Pictures International (UPI) | false |
| 14 | Balls of Fury | - | - | - | $13,099 | 1 | $13,908 | May 16 | Garsu Pasaulio Irasai | false |
| 15 | Horton Hears a Who! | - | - | - | $10,995 | 7 | $227,943 | Mar 21 | Universal Pictures International (UPI) | false |
| 16 | 10,000 BC | - | - | - | $10,335 | 3 | $238,988 | Mar 14 | Universal Pictures International (UPI) | false |
| 17 | Feast of Love | - | - | - | $7,552 | 1 | $25,833 | Apr 18 | ACME | false |
| 18 | Rambo | - | - | - | $7,136 | 1 | $16,026 | Apr 25 | Garsu Pasaulio Irasai | false |
| 19 | Shutter | - | - | - | $2,904 | 1 | $65,852 | Mar 28 | Universal Pictures International (UPI) | false |
| 20 | Sleuth | - | - | - | $2,774 | 1 | $79,577 | Mar 28 | ACME | false |
