| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man | - | - | - | $88,504 | 9 | $101,817 | May 1 | - | false |
| 2 | What Happens in Vegas | - | - | - | $82,745 | 7 | $202,649 | May 15 | - | false |
| 3 | Made of Honor | - | - | - | $70,077 | 7 | $111,357 | May 1 | - | false |
| 4 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $54,922 | 10 | $150,962 | May 29 | - | false |
| 5 | Mme Bambino | - | - | - | $34,967 | 6 | $266,835 | Mar 27 | - | false |
| 6 | Fool's Gold | - | - | - | $32,514 | 7 | $70,995 | Apr 24 | - | false |
| 7 | 21 | - | - | - | $31,426 | 5 | $89,757 | Apr 17 | - | false |
| 8 | Superhero Movie | - | - | - | $19,499 | 7 | $52,977 | Apr 24 | - | false |
| 9 | College Road Trip | - | - | - | $16,616 | 8 | $68,116 | May 15 | - | false |
| 10 | Two Days in Paris | - | - | - | $16,138 | 2 | $19,820 | May 8 | - | false |
| 11 | Drillbit Taylor | - | - | - | $11,604 | 7 | $11,604 | May 15 | - | false |
| 12 | Untraceable | - | - | - | $10,836 | 7 | $63,544 | Apr 10 | - | false |
| 13 | Never Back Down | - | - | - | $9,241 | 6 | $23,618 | Apr 24 | - | false |
| 14 | Sleeping Dogs Lie | - | - | - | $8,847 | 3 | $8,847 | May 1 | - | false |
| 15 | Sydney White | - | - | - | $8,231 | 4 | $8,231 | May 1 | - | false |
| 16 | Rogue | - | - | - | $7,358 | 7 | $11,244 | May 22 | - | false |
| 17 | The Lark Farm | - | - | - | $6,977 | 3 | $33,107 | Apr 17 | - | false |
| 18 | Reservation Road | - | - | - | $6,530 | 5 | $7,802 | May 8 | - | false |
| 19 | The Eye | - | - | - | $5,868 | 5 | $12,663 | Apr 24 | - | false |
| 20 | Doomsday | - | - | - | $5,667 | 7 | $12,870 | Apr 24 | - | false |
| 21 | Speed Racer | - | - | - | $5,611 | 6 | $5,611 | May 22 | - | false |
| 22 | Khallik Maai | - | - | - | $4,395 | 5 | $94,116 | Feb 7 | - | false |
| 23 | Definitely, Maybe | - | - | - | $4,325 | 8 | $85,754 | Apr 3 | - | false |
| 24 | The Island | - | - | - | $3,626 | 6 | $34,725 | Apr 3 | - | false |
| 25 | Mad Money | - | - | - | $3,600 | 5 | $14,702 | May 29 | - | false |
| 26 | The Other Boleyn Girl | - | - | - | $3,150 | 7 | $70,788 | Mar 27 | - | false |
| 27 | Persepolis | - | - | - | $2,867 | 2 | $20,550 | Mar 27 | - | false |
| 28 | Asterix at the Olympic Games | - | - | - | $2,791 | 6 | $104,694 | Mar 20 | - | false |
| 29 | Mr. Woodcock | - | - | - | $2,713 | 5 | $2,864 | May 22 | - | false |
| 30 | Awake | - | - | - | $1,970 | 6 | $29,402 | Mar 20 | - | false |
| 31 | Kharej ala el kanoun | - | - | - | $1,163 | 4 | $4,808 | May 29 | - | false |
| 32 | Hallam Foe | - | - | - | $966 | 1 | $3,023 | Apr 24 | - | false |
| 33 | Princess of the Sun | - | - | - | $939 | 1 | $8,935 | Mar 27 | - | false |
| 34 | Under the Bombs | - | - | - | $621 | 7 | $237,851 | Dec 13 | - | false |
| 35 | Saw IV | - | - | - | $489 | 2 | $1,697 | May 29 | - | false |
| 36 | Juno | - | - | - | $483 | 4 | $11,672 | Apr 17 | - | false |
| 37 | In the Name of the King: A Dungeon Siege Tale | - | - | - | $188 | 4 | $16,549 | Apr 3 | - | false |
| 38 | Things We Lost in the Fire | - | - | - | $107 | 7 | $12,161 | Apr 17 | - | false |
| 39 | Eastern Promises | - | - | - | $89 | 6 | $25,286 | Jan 10 | - | false |
| 40 | Boot Camp | - | - | - | $60 | 5 | $4,900 | Apr 10 | - | false |
