| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $11,457,346 | 689 | $18,982,360 | May 23 | Universal Pictures International (UPI) | false |
| 2 | Gomorrah | - | - | - | $10,315,310 | 441 | $17,665,830 | May 16 | 01 Distribution | false |
| 3 | Iron Man | - | - | - | $8,791,683 | 509 | $10,809,921 | May 1 | Universal Pictures International (UPI) | false |
| 4 | What Happens in Vegas | - | - | - | $4,586,176 | 295 | $5,188,588 | May 9 | 20th Century Fox International | false |
| 5 | Superhero Movie | - | - | - | $3,714,245 | 362 | $4,416,797 | May 16 | Medusa Distribuzione | false |
| 6 | Saw IV | - | - | - | $3,353,629 | 337 | $4,328,882 | Apr 30 | 01 Distribution | false |
| 7 | Sex and the City | - | - | - | $2,739,591 | 552 | $9,817,656 | May 30 | 01 Distribution | false |
| 8 | Il Divo | - | - | - | $1,542,798 | 358 | $8,517,653 | May 28 | Lucky Red | false |
| 9 | Mongol: The Rise of Genghis Khan | - | - | - | $1,187,529 | 137 | $1,325,000 | May 9 | BIM Distribuzione | false |
| 10 | The Other Boleyn Girl | - | - | - | $1,086,603 | 102 | $2,180,712 | Apr 24 | Universal Pictures International (UPI) | false |
| 11 | Meet the Spartans | - | - | - | $1,079,999 | 286 | $3,769,624 | Apr 24 | 20th Century Fox International | false |
| 12 | Gli ultimi della strada | - | - | - | $1,028,095 | 252 | $1,062,945 | May 16 | 01 Distribution | false |
| 13 | 21 | - | - | - | $950,235 | 247 | $3,927,213 | Apr 18 | Sony Pictures Releasing | false |
| 14 | Step Up 2: The Streets | - | - | - | $945,602 | 333 | $5,313,261 | Apr 18 | Moviemax | false |
| 15 | The Hunting Party | - | - | - | $848,533 | 255 | $1,087,953 | Apr 30 | Mikado Film | false |
| 16 | The Darjeeling Limited | - | - | - | $831,124 | 70 | $1,237,762 | Apr 30 | 20th Century Fox International | false |
| 17 | Speed Racer | - | - | - | $769,874 | 396 | $756,653 | May 9 | Warner Bros. | false |
| 18 | The Demons of St. Petersburg | - | - | - | $653,802 | 110 | $1,409,678 | Apr 24 | 01 Distribution | false |
| 19 | The Kite Runner | - | - | - | $605,884 | 371 | $12,730,140 | Mar 28 | Filmauro | false |
| 20 | Wild Blood | - | - | - | $593,327 | 215 | $932,866 | May 23 | 01 Distribution | false |
| 21 | In Bruges | - | - | - | $588,716 | 151 | $772,903 | May 16 | Mikado Film | false |
| 22 | L'anno mille | - | - | - | $577,570 | 38 | $777,830 | Apr 24 | Mediafilm | false |
| 23 | Horton Hears a Who! | - | - | - | $521,700 | 463 | $3,958,990 | Apr 18 | 20th Century Fox International | false |
| 24 | Carnera: The Walking Mountain | - | - | - | $404,838 | 244 | $408,793 | May 9 | Medusa Distribuzione | false |
| 25 | The Hitcher | - | - | - | $404,297 | 205 | $1,092,472 | May 30 | Medusa Distribuzione | false |
| 26 | Tutta la vita davanti | - | - | - | $364,811 | 368 | $5,648,340 | Mar 28 | Medusa Distribuzione | false |
| 27 | Evening | - | - | - | $363,931 | 180 | $1,160,067 | Apr 24 | Medusa Distribuzione | false |
| 28 | Before the Devil Knows You're Dead | - | - | - | $345,457 | 277 | $4,648,889 | Mar 14 | Medusa Distribuzione | false |
| 29 | Leatherheads | - | - | - | $339,872 | 218 | $3,763,108 | Apr 11 | Universal Pictures International (UPI) | false |
| 30 | Non pensarci | - | - | - | $336,402 | 222 | $2,239,655 | Apr 4 | 01 Distribution | false |
| 31 | King of California | - | - | - | $299,778 | 110 | $300,080 | May 16 | Moviemax | false |
| 32 | The Girl by the Lake | - | - | - | $298,757 | 143 | $4,688,666 | Sep 14 | Medusa Distribuzione | false |
| 33 | Rise: Blood Hunter | - | - | - | $298,576 | 127 | $326,477 | May 23 | Eagle Pictures | false |
| 34 | Juno | - | - | - | $252,779 | 239 | $3,352,339 | Apr 4 | 20th Century Fox International | false |
| 35 | Nim's Island | - | - | - | $235,633 | 304 | $4,095,643 | Apr 11 | Moviemax | false |
| 36 | Fool's Gold | - | - | - | $203,473 | 232 | $1,013,544 | Apr 23 | Warner Bros. | false |
| 37 | La seconda volta non si scorda mai | - | - | - | $195,754 | 217 | $2,675,946 | Apr 11 | Mikado Film | false |
| 38 | When Darkness Falls 2008 Re-release | - | - | - | $183,285 | 31 | $218,530 | May 2 | Teodora Film | false |
| 39 | Be Kind Rewind | - | - | - | $163,448 | 95 | $220,443 | May 23 | BIM Distribuzione | false |
| 40 | Definitely, Maybe | - | - | - | $133,405 | 100 | $134,760 | May 16 | Universal Pictures International (UPI) | false |
| 41 | Shall We Kiss? | - | - | - | $130,933 | 36 | $140,508 | May 9 | - | false |
| 42 | Over Her Dead Body | - | - | - | $108,297 | 133 | $507,321 | Apr 24 | Eagle Pictures | false |
| 43 | Reservation Road | - | - | - | $104,831 | 103 | $104,831 | May 23 | Warner Bros. | false |
| 44 | Next | - | - | - | $97,623 | 289 | $4,522,275 | Apr 4 | Medusa Distribuzione | false |
| 45 | The Band's Visit | - | - | - | $89,827 | 51 | $919,800 | Mar 21 | Mikado Film | false |
| 46 | Introducing the Dwights | - | - | - | $77,656 | 69 | $386,825 | Apr 18 | Lucky Red | false |
| 47 | The Fox and the Child | - | - | - | $73,905 | 240 | $2,400,103 | Mar 21 | Lucky Red | false |
| 48 | U2 3D | - | - | - | $72,161 | 31 | $182,003 | Apr 24 | Independent Films | false |
| 49 | Once | - | - | - | $67,434 | 35 | $746,500 | May 30 | Sacher Distribuzione | false |
| 50 | Tutto torna | - | - | - | $66,096 | 8 | $84,447 | May 9 | - | false |
| 51 | Surviving with Wolves | - | - | - | $63,516 | 43 | $88,101 | May 2 | Warner Bros. | false |
| 52 | The Zone | - | - | - | $61,811 | 27 | $312,516 | Apr 4 | Sacher Distribuzione | false |
| 53 | Under the Bombs | - | - | - | $61,132 | 17 | $69,275 | May 2 | Fandango | false |
| 54 | Maradona by Kusturica | - | - | - | $54,394 | 82 | $160,690 | May 30 | BIM Distribuzione | false |
| 55 | The Last Deadly Mission | - | - | - | $54,298 | 161 | $829,466 | Apr 18 | Medusa Distribuzione | false |
| 56 | Underdog | - | - | - | $53,629 | 15 | $74,430 | May 16 | Walt Disney Pictures | false |
| 57 | Shine a Light | - | - | - | $51,036 | 57 | $479,849 | Apr 11 | BIM Distribuzione | false |
| 58 | Chiamami Salomè | - | - | - | $46,797 | 6 | $57,999 | May 9 | Mediaplex | false |
| 59 | The Wind Blows Round | - | - | - | $38,811 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 60 | Tuttifrutti | - | - | - | $36,619 | 21 | $103,007 | May 16 | - | false |
| 61 | Chi nasce tondo... | - | - | - | $33,486 | 4 | $33,486 | May 16 | Istituto Luce | false |
| 62 | Cover Boy... Last Revolution | - | - | - | $32,263 | 8 | $147,184 | Mar 21 | Istituto Luce | false |
| 63 | Ci sta un francese, un inglese e un napoletano | - | - | - | $29,795 | 64 | $843,004 | Mar 28 | Medusa Distribuzione | false |
| 64 | 10 Items or Less | - | - | - | $28,921 | 35 | $226,695 | Apr 18 | DNC Entertainment | false |
| 65 | The Early Bird Catches the Worm | - | - | - | $27,915 | 253 | $1,550,893 | Feb 29 | Medusa Distribuzione | false |
| 66 | The Oxford Murders | - | - | - | $23,839 | 100 | $817,983 | Apr 11 | Warner Bros. | false |
| 67 | Charlie Bartlett | - | - | - | $22,144 | 31 | $51,943 | May 30 | DNC Entertainment | false |
| 68 | Good Morning Heartache | - | - | - | $22,102 | 79 | $278,471 | Apr 11 | Medusa Distribuzione | false |
| 69 | The City of Lost Children | - | - | - | $15,758 | 1 | $42,854 | - | - | false |
| 70 | Gone Baby Gone | - | - | - | $14,758 | 16 | $115,103 | Apr 4 | Walt Disney Pictures | false |
| 71 | Love Is Not Enough | - | - | - | $11,261 | 76 | $698,276 | Apr 18 | Mediafilm | false |
| 72 | Il Nostro Messia | - | - | - | $10,873 | 1 | $11,622 | May 23 | - | false |
| 73 | Alexandra | - | - | - | $9,042 | 7 | $77,404 | May 30 | - | false |
| 74 | Cargo 200 | - | - | - | $7,895 | 7 | $7,895 | May 9 | Archibald | false |
| 75 | Amore, bugie & calcetto | - | - | - | $4,436 | 313 | $2,222,029 | Apr 4 | Warner Bros. | false |
| 76 | Something's Gotta Give | - | - | - | $4,153 | 264 | $8,441,993 | Feb 6 | - | false |
| 77 | My Blueberry Nights | - | - | - | $3,897 | 133 | $669,987 | Mar 28 | BIM Distribuzione | false |
| 78 | Ultimo bersaglio | - | - | - | $3,450 | 1 | $24,775 | Jun 5 | Independent Films | false |
| 79 | Slipstream | - | - | - | $3,249 | 4 | $3,769 | May 9 | - | false |
| 80 | There Will Be Blood | - | - | - | $3,083 | 111 | $2,566,966 | Feb 15 | Walt Disney Pictures | false |
| 81 | Quiet Chaos | - | - | - | $2,813 | 384 | $9,204,569 | Feb 8 | 01 Distribution | false |
| 82 | Into the Wild | - | - | - | $2,739 | 191 | $8,058,998 | Jan 25 | BIM Distribuzione | false |
| 83 | Persepolis | - | - | - | $2,415 | 94 | $1,785,411 | Feb 22 | BIM Distribuzione | false |
| 84 | The Secret of the Grain | - | - | - | $1,627 | 79 | $2,875,013 | Jan 11 | Lucky Red | false |
| 85 | Jimmy della collina | - | - | - | $1,561 | 5 | $71,846 | Apr 4 | Aranciafilm | false |
| 86 | The Water Horse | - | - | - | $1,491 | 176 | $1,946,763 | Mar 14 | Sony Pictures Releasing | false |
| 87 | Nelle tue mani | - | - | - | $1,363 | 18 | $111,266 | Mar 14 | Teodora Film | false |
| 88 | Mars 2008 Re-release | - | - | - | $1,309 | 2 | $7,223 | Mar 28 | Officine UBU | false |
| 89 | August Rush | - | - | - | $1,071 | 190 | $1,462,687 | Nov 30 | Medusa Distribuzione | false |
