| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Sex and the City | - | - | - | $52,276,151 | 470 | $17,374,683 | 33.2% | 460 | May 28 | - | Entertainment Film Distributors | false |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $50,771,279 | 540 | $24,146,846 | 47.6% | 538 | May 22 | - | Paramount Pictures International | false |
| 3 | Iron Man | - | - | - | $34,282,266 | 500 | $10,772,921 | 31.4% | 500 | May 2 | - | Paramount Pictures International | false |
| 4 | What Happens in Vegas | - | - | - | $15,639,183 | 405 | $2,467,460 | 15.8% | 398 | May 9 | - | 20th Century Fox International | false |
| 5 | Nim's Island | - | - | - | $7,784,514 | 393 | $1,616,830 | 20.8% | 393 | May 2 | - | Universal Pictures International (UPI) | false |
| 6 | Made of Honor | - | - | - | $4,699,956 | 348 | $1,477,648 | 31.4% | 348 | May 2 | - | Sony Pictures Releasing | false |
| 7 | Speed Racer | - | - | - | $3,240,114 | 457 | $707,369 | 21.8% | 442 | May 9 | - | Warner Bros. | false |
| 8 | Doomsday | - | - | - | $2,061,794 | 259 | $608,289 | 29.5% | 257 | May 9 | - | Universal Pictures International (UPI) | false |
| 9 | Harold & Kumar Escape from Guantanamo Bay | - | - | - | $1,359,602 | 181 | $525,854 | 38.7% | 177 | May 30 | - | Entertainment Film Distributors | false |
| 10 | Caramel | - | - | - | $902,814 | 49 | $240,247 | 26.6% | 46 | May 16 | - | Momentum Pictures | false |
| 11 | Bhoothnath | - | - | - | $404,071 | 34 | $127,693 | 31.6% | 33 | May 9 | - | Eros Worldwide | false |
| 12 | Smart People | - | - | - | $400,097 | 73 | $172,637 | 43.1% | 73 | May 16 | - | Icon Film Distribution Australia | false |
| 13 | Charlie Bartlett | - | - | - | $388,748 | 202 | $190,141 | 48.9% | 202 | May 16 | - | Verve Pictures | false |
| 14 | Shutter | - | - | - | $368,489 | 65 | $141,996 | 38.5% | 65 | May 16 | - | 20th Century Fox International | false |
| 15 | Jannat: In Search of Heaven... | - | - | - | $302,341 | 21 | $96,371 | 31.9% | 21 | May 16 | - | Tip Top Entertainment (TTE) | false |
| 16 | Kuruvi | - | - | - | $263,919 | 16 | $152,431 | 57.8% | 13 | May 2 | - | Ayngaran International | false |
| 17 | Cassandra's Dream | - | - | - | $239,955 | 50 | $93,522 | 39% | 50 | May 23 | - | Optimum Releasing | false |
| 18 | Joy Division | - | - | - | $182,842 | 6 | - | - | - | May 2 | - | - | false |
| 19 | Jules and Jim 2008 Re-release | - | - | - | $174,288 | 13 | $50,711 | 29.1% | 13 | May 30 | - | British Film Institute (BFI) | false |
| 20 | Honeydripper | - | - | - | $168,534 | 18 | $38,336 | 22.7% | 18 | May 9 | - | Axiom Films | false |
| 21 | Heartbeat Detector | - | - | - | $158,771 | 6 | $31,757 | 20% | 6 | May 16 | - | Trinity Filmed Entertainment | false |
| 22 | Outpost | - | - | - | $146,104 | 51 | $75,656 | 51.8% | 51 | May 16 | - | Vertigo Films | false |
| 23 | Where in the World Is Osama Bin Laden? | - | - | - | $142,956 | 38 | $51,866 | 36.3% | 38 | May 9 | - | Optimum Releasing | false |
| 24 | P2 | - | - | - | $141,787 | 124 | $72,198 | 50.9% | 124 | May 2 | - | Tartan | false |
| 25 | Welcome Home, Roscoe Jenkins | - | - | - | $126,464 | 100 | $80,024 | 63.3% | 100 | May 30 | - | Universal Pictures International (UPI) | false |
| 26 | XXY | - | - | - | $122,577 | 8 | $21,502 | 17.5% | 7 | May 9 | - | Peccadillo Pictures | false |
| 27 | A Secret | - | - | - | $68,262 | 3 | $15,534 | 22.8% | 2 | May 9 | - | Arrow Films | false |
| 28 | California Dreamin' | - | - | - | $58,590 | 6 | $19,009 | 32.4% | 6 | May 30 | - | Artificial Eye | false |
| 29 | Timber Falls | - | - | - | $53,335 | 22 | $24,208 | 45.4% | 22 | May 23 | - | Scanbox Entertainment | false |
| 30 | Mr. White Mr. Black | - | - | - | $51,321 | 11 | $29,852 | 58.2% | 11 | May 2 | - | Eros Worldwide | false |
| 31 | Manufactured Landscapes | - | - | - | $41,503 | 6 | $10,908 | 26.3% | 6 | May 9 | - | British Film Institute (BFI) | false |
| 32 | Woodstock Villa | - | - | - | $38,830 | 13 | $24,485 | 63.1% | 13 | May 30 | - | DM Productions | false |
| 33 | Terror's Advocate | - | - | - | $35,887 | 3 | $5,850 | 16.3% | 2 | May 16 | - | Artificial Eye | false |
| 34 | Shotgun Stories | - | - | - | $35,365 | 7 | $8,525 | 24.1% | 7 | May 23 | - | Vertigo Films | false |
| 35 | Some Came Running | - | - | - | $28,594 | 2 | $8,484 | 29.7% | 2 | May 16 | - | British Film Institute (BFI) | false |
| 36 | Chemical Wedding | - | - | - | $9,439 | 18 | $9,439 | 100% | 18 | May 30 | - | Warner Music | false |
| 37 | Garbage Warrior | - | - | - | $8,844 | 2 | $2,422 | 27.4% | 2 | May 23 | - | ICA Films | false |
| 38 | Dangerous Parking | - | - | - | $7,337 | 7 | $2,929 | 39.9% | 7 | May 23 | - | Delanic Films | false |
| 39 | The Air I Breathe | - | - | - | $7,058 | 3 | $3,909 | 55.4% | 3 | May 16 | - | Pathé | false |
| 40 | Vexille | - | - | - | $6,377 | 1 | $1,344 | 21.1% | 1 | May 9 | - | Momentum Pictures | false |
| 41 | Cashback | - | - | - | $6,103 | 4 | $2,987 | 48.9% | 4 | May 9 | - | The Works UK Distribution | false |
| 42 | The Unwinking Gaze: The Inside Story of the Dalai Lama's Struggle for Tibet | - | - | - | $3,155 | 5 | $3,155 | 100% | 5 | May 29 | - | MercuryMedia International | false |
| 43 | Winter Soldier | - | - | - | $2,825 | 1 | $1,364 | 48.3% | 1 | May 8 | - | Stoney Road Films | false |
| 44 | Tovarisch, I Am Not Dead | - | - | - | $2,397 | 1 | $2,397 | 100% | 1 | May 2 | - | - | false |
| 45 | RFK Must Die: The Assassination of Bobby Kennedy | - | - | - | $2,218 | 2 | $1,141 | 51.4% | 2 | May 16 | - | Soda Pictures | false |
| 46 | Mouth to Mouth 2008 Re-release | - | - | - | $1,667 | 1 | $920 | 55.2% | 1 | May 9 | - | - | false |
| 47 | I Served the King of England | - | - | - | $1,407 | 1 | $1,407 | 100% | 1 | May 9 | - | Arrow Films | false |
