| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $12,972,879 | 732 | $32,751,799 | May 22 | Universal Pictures International (UPI) | false |
| 2 | What Happens in Vegas | - | - | - | $8,937,018 | 408 | $11,838,452 | May 9 | 20th Century Fox International | false |
| 3 | Iron Man | - | - | - | $8,203,851 | 559 | $12,030,026 | Apr 30 | Sony Pictures Releasing | false |
| 4 | 88 Minutes | - | - | - | $2,597,370 | 171 | $3,919,422 | Apr 30 | Filmax | false |
| 5 | Chef's Special | - | - | - | $2,223,285 | 232 | $7,819,057 | Apr 11 | Warner Bros. | false |
| 6 | Street Kings | - | - | - | $2,158,275 | 302 | $4,185,842 | Apr 25 | 20th Century Fox International | false |
| 7 | Speed Racer | - | - | - | $1,705,000 | 427 | $2,048,700 | May 9 | Warner Bros. | false |
| 8 | 21 | - | - | - | $1,460,734 | 255 | $6,840,432 | Apr 11 | Sony Pictures Releasing | false |
| 9 | Fool's Gold | - | - | - | $1,340,957 | 272 | $2,959,860 | Apr 25 | Warner Bros. | false |
| 10 | Elegy | - | - | - | $1,339,544 | 128 | $3,914,620 | Apr 18 | On Pictures | false |
| 11 | Prom Night | - | - | - | $1,181,641 | 228 | $1,873,142 | May 14 | Sony Pictures Releasing | false |
| 12 | Casual Day | - | - | - | $1,100,645 | 120 | $1,405,814 | May 9 | Walt Disney Pictures | false |
| 13 | My Mom's New Boyfriend | - | - | - | $1,013,480 | 202 | $1,324,291 | Apr 30 | DeAPlaneta | false |
| 14 | Death Sentence | - | - | - | $806,293 | 139 | $1,263,144 | May 16 | TriPictures | false |
| 15 | Before the Devil Knows You're Dead | - | - | - | $735,687 | 106 | $3,620,899 | May 23 | Baditri | false |
| 16 | Cowards | - | - | - | $730,395 | 251 | $1,528,988 | Apr 25 | Filmax | false |
| 17 | The Game Plan | - | - | - | $671,358 | 250 | $6,016,924 | Mar 28 | Walt Disney Pictures | false |
| 18 | A Thousand Years of Good Prayers | - | - | - | $490,927 | 337 | $1,163,809 | Apr 18 | Karma Films | false |
| 19 | Shutter | - | - | - | $483,512 | 300 | $3,782,211 | Apr 11 | 20th Century Fox International | false |
| 20 | Horton Hears a Who! | - | - | - | $415,184 | 476 | $11,301,036 | Mar 14 | 20th Century Fox International | false |
| 21 | Shattered | - | - | - | $357,292 | 107 | $482,919 | Apr 30 | Manga Entertainment | false |
| 22 | 8 Dates | - | - | - | $352,256 | 171 | $1,354,462 | Apr 18 | Alta Films | false |
| 23 | A Girl Cut in Two | - | - | - | $312,223 | 39 | $493,500 | May 16 | Wanda Visión S.A. | false |
| 24 | Drillbit Taylor | - | - | - | $290,954 | 112 | $406,806 | May 16 | Universal Pictures International (UPI) | false |
| 25 | Late Bloomers | - | - | - | $253,435 | 18 | $416,081 | May 9 | Yedra Films | false |
| 26 | Never Back Down | - | - | - | $250,522 | 202 | $1,628,270 | Apr 18 | Aurum Films | false |
| 27 | The Counterfeiters | - | - | - | $233,443 | 119 | $3,871,085 | Mar 14 | Wanda Visión S.A. | false |
| 28 | Island of Lost Souls | - | - | - | $225,754 | 59 | $408,900 | May 16 | Flins & Piniculas | false |
| 29 | Rudy: The Return of the Racing Pig | - | - | - | $220,059 | 64 | $407,216 | Apr 25 | Flins & Piniculas | false |
| 30 | Definitely, Maybe | - | - | - | $219,698 | 45 | $306,791 | May 9 | Universal Pictures International (UPI) | false |
| 31 | A Tram in SP | - | - | - | $214,014 | 52 | $271,475 | Apr 30 | Aurum Films | false |
| 32 | Rendition | - | - | - | $187,872 | 222 | $1,350,950 | Apr 18 | TriPictures | false |
| 33 | The Savages | - | - | - | $177,723 | 48 | $989,819 | Apr 4 | 20th Century Fox International | false |
| 34 | Todos estamos invitados | - | - | - | $164,262 | 111 | $1,251,557 | Apr 11 | Alta Films | false |
| 35 | Be Kind Rewind | - | - | - | $152,505 | 32 | $561,516 | Apr 11 | Universal Pictures International (UPI) | false |
| 36 | The Duchess of Langeais | - | - | - | $142,918 | 10 | $188,572 | Apr 30 | Baditri | false |
| 37 | The Edge of Heaven | - | - | - | $141,887 | 33 | $1,340,082 | Mar 14 | Golem Distribución | false |
| 38 | Lars and the Real Girl | - | - | - | $133,545 | 21 | $287,503 | Apr 25 | Versus Entertainment | false |
| 39 | Things We Lost in the Fire | - | - | - | $131,458 | 68 | $322,292 | Apr 25 | Universal Pictures International (UPI) | false |
| 40 | The Band's Visit | - | - | - | $131,243 | 27 | $462,560 | Apr 11 | Manga Entertainment | false |
| 41 | Days of Darkness | - | - | - | $109,366 | 26 | $380,203 | Apr 11 | Golem Distribución | false |
| 42 | Sultanes del Sur | - | - | - | $109,208 | 113 | $277,041 | May 16 | Filmax | false |
| 43 | Before the Fall | - | - | - | $100,612 | 128 | $328,946 | Apr 25 | Universal Pictures International (UPI) | false |
| 44 | The Kite Runner | - | - | - | $98,712 | 135 | $1,870,588 | Mar 7 | Universal Pictures International (UPI) | false |
| 45 | The Ruins | - | - | - | $91,331 | 200 | $787,302 | Apr 18 | Universal Pictures International (UPI) | false |
| 46 | Courthouse on Horseback | - | - | - | $90,281 | 17 | $335,160 | May 23 | Karma Films | false |
| 47 | The Water Horse | - | - | - | $86,720 | 205 | $3,438,882 | Mar 7 | Sony Pictures Releasing | false |
| 48 | La crisis carnívora | - | - | - | $85,472 | 84 | $94,858 | May 16 | Aurum Films | false |
| 49 | We Own the Night | - | - | - | $83,705 | 224 | $3,742,720 | Mar 28 | Universal Pictures International (UPI) | false |
| 50 | The Contract | - | - | - | $80,589 | 121 | $1,885,696 | Apr 4 | Filmax | false |
| 51 | Untraceable | - | - | - | $69,918 | 201 | $1,893,655 | Apr 4 | Universal Pictures International (UPI) | false |
| 52 | Death Defying Acts | - | - | - | $66,152 | 250 | $2,839,345 | Apr 4 | DeAPlaneta | false |
| 53 | The Spiderwick Chronicles | - | - | - | $60,359 | 291 | $5,532,022 | Mar 14 | Universal Pictures International (UPI) | false |
| 54 | Enloquecidas | - | - | - | $58,833 | 10 | $200,134 | Apr 11 | Premium Film | false |
| 55 | The Pope's Toilet | - | - | - | $50,931 | 15 | $94,542 | Apr 25 | Golem Distribución | false |
| 56 | Cashback | - | - | - | $50,395 | 26 | $206,570 | Apr 11 | Laurenfilm | false |
| 57 | Honeydripper | - | - | - | $48,538 | 7 | $85,165 | May 16 | Golem Distribución | false |
| 58 | Abrígate | - | - | - | $44,940 | 20 | $87,863 | May 23 | Walt Disney Pictures | false |
| 59 | The Aerial | - | - | - | $35,931 | 4 | $45,123 | May 9 | Sherlock Films | false |
| 60 | Bab'Aziz: The Prince That Contemplated His Soul | - | - | - | $34,253 | 6 | $257,291 | Mar 7 | Karma Films | false |
| 61 | Dan in Real Life | - | - | - | $33,946 | 191 | $2,706,563 | Mar 19 | Universal Pictures International (UPI) | false |
| 62 | Caramel | - | - | - | $29,467 | 60 | $1,848,875 | Jan 18 | Alta Films | false |
| 63 | Franklin and the Turtle Lake Treasure | - | - | - | $28,016 | 106 | $766,086 | Feb 22 | Wanda Visión S.A. | false |
| 64 | Meet the Spartans | - | - | - | $22,031 | 316 | $6,542,138 | Mar 28 | 20th Century Fox International | false |
| 65 | Broken Sky | - | - | - | $20,483 | 2 | $25,811 | May 16 | Karma Films | false |
| 66 | Shine a Light | - | - | - | $18,320 | 67 | $277,526 | Apr 4 | Vértigo Films | false |
| 67 | Closing the Ring | - | - | - | $16,006 | 24 | $269,893 | Mar 14 | Manga Entertainment | false |
| 68 | Mirror Maze | - | - | - | $14,843 | 124 | $119,572 | Apr 25 | Walt Disney Pictures | false |
| 69 | 4 Months, 3 Weeks and 2 Days | - | - | - | $14,773 | 36 | $1,063,172 | Jan 25 | Golem Distribución | false |
| 70 | 30 Days of Night | - | - | - | $13,294 | 300 | $4,113,870 | Feb 8 | Sony Pictures Releasing | false |
| 71 | Buddha Collapsed Out of Shame | - | - | - | $13,005 | 19 | $489,438 | Feb 29 | Wanda Visión S.A. | false |
| 72 | There Will Be Blood | - | - | - | $11,571 | 104 | $2,415,805 | Feb 15 | Walt Disney Pictures | false |
| 73 | The Silence Before Bach | - | - | - | $8,738 | 5 | $322,116 | Dec 21 | Sherlock Films | false |
| 74 | Reencarnación | - | - | - | $8,604 | 1 | $9,147 | Apr 30 | - | false |
| 75 | Asterix at the Olympic Games | - | - | - | $7,991 | 385 | $9,181,000 | Feb 8 | TriPictures | false |
| 76 | Juno | - | - | - | $5,856 | 200 | $8,237,494 | Feb 1 | 20th Century Fox International | false |
| 77 | 10,000 BC | - | - | - | $5,691 | 475 | $13,119,769 | Mar 7 | Warner Bros. | false |
| 78 | One Missed Call | - | - | - | $5,333 | 165 | $2,119,000 | Mar 19 | Warner Bros. | false |
| 79 | Stop-Loss | - | - | - | $4,703 | 8 | $7,245 | May 9 | Universal Pictures International (UPI) | false |
| 80 | It's a Free World... | - | - | - | $4,081 | 85 | $565,458 | Feb 22 | Alta Films | false |
| 81 | Rogue | - | - | - | $3,853 | 122 | $291,329 | Apr 4 | Notro Films | false |
| 82 | Lo mejor de mí | - | - | - | $2,828 | 30 | $401,227 | Mar 7 | Alta Films | false |
| 83 | Silk | - | - | - | $1,641 | 160 | $2,029,874 | Mar 19 | TriPictures | false |
| 84 | Love and Honor | - | - | - | $1,506 | 4 | $37,174 | Mar 28 | Notro Films | false |
| 85 | Irina Palm | - | - | - | $1,504 | 32 | $807,806 | Dec 14 | Golem Distribución | false |
| 86 | 27 Dresses | - | - | - | $1,471 | 310 | $6,462,303 | Feb 29 | 20th Century Fox International | false |
| 87 | The Oxford Murders | - | - | - | $942 | 271 | $12,525,441 | Jan 18 | Warner Bros. | false |
| 88 | American Gangster | - | - | - | $882 | 440 | $14,529,675 | Dec 28 | Universal Pictures International (UPI) | false |
| 89 | Vantage Point | - | - | - | $806 | 373 | $6,721,872 | Feb 28 | Sony Pictures Releasing | false |
| 90 | La Osa Mayor menos dos | - | - | - | $769 | 2 | $769 | May 9 | Sagrera TV | false |
| 91 | The Other Boleyn Girl | - | - | - | $605 | 217 | $5,865,854 | Feb 29 | Universal Pictures International (UPI) | false |
| 92 | Once | - | - | - | $419 | 27 | $879,999 | Oct 31 | Avalon | false |
| 93 | Joe Strummer: The Future Is Unwritten | - | - | - | $370 | 4 | $46,332 | Apr 4 | Avalon | false |
| 94 | Love Sick 2008 Re-release | - | - | - | $359 | 11 | $36,446 | Mar 28 | Baditri | false |
| 95 | Lust, Caution | - | - | - | $107 | 126 | $2,247,011 | Dec 14 | Universal Pictures International (UPI) | false |
| 96 | Women on the Verge of a Nervous Breakdown 2008 Re-release | - | - | - | $31 | 5 | $10,840 | Apr 11 | Warner Bros. | false |
