| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $117,194 | 5 | $276,765 | May 22 | - | false |
| 2 | What Happens in Vegas | - | - | - | $97,551 | 3 | $186,816 | May 9 | - | false |
| 3 | Iron Man | - | - | - | $71,666 | 3 | $83,069 | May 1 | - | false |
| 4 | Made of Honor | - | - | - | $32,111 | 2 | $49,095 | May 1 | - | false |
| 5 | Forgetting Sarah Marshall | - | - | - | $30,464 | 2 | $52,879 | Apr 25 | - | false |
| 6 | The Bucket List | - | - | - | $18,833 | 1 | $42,893 | Apr 18 | - | false |
| 7 | 21 | - | - | - | $17,892 | 1 | $44,194 | Apr 18 | - | false |
| 8 | Horton Hears a Who! | - | - | - | $14,170 | 8 | $305,929 | Mar 14 | - | false |
| 9 | Shutter | - | - | - | $11,250 | 1 | $24,916 | Apr 25 | - | false |
| 10 | The Ruins | - | - | - | $10,426 | 1 | $40,835 | Apr 18 | - | false |
| 11 | Deception | - | - | - | $10,240 | 2 | $10,565 | May 9 | - | false |
| 12 | Speed Racer | - | - | - | $9,796 | 3 | $13,196 | May 16 | - | false |
| 13 | Baby Mama | - | - | - | $8,015 | 1 | $11,736 | May 16 | - | false |
| 14 | Fool's Gold | - | - | - | $7,132 | 3 | $86,561 | Apr 4 | - | false |
| 15 | Street Kings | - | - | - | $4,793 | 3 | $50,220 | Apr 11 | - | false |
| 16 | 10,000 BC | - | - | - | $1,175 | 4 | $153,429 | Mar 21 | - | false |
| 17 | Vantage Point | - | - | - | $133 | 2 | $30,593 | Mar 7 | - | false |
