| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Chronicles of Narnia: Prince Caspian | - | - | - | $1,516,120 | 71 | $2,215,829 | May 15 | Walt Disney Pictures | false |
| 2 | Iron Man | - | - | - | $1,278,443 | 41 | $1,383,728 | Apr 30 | United International Pictures | false |
| 3 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $872,758 | 70 | $1,255,634 | May 22 | United International Pictures | false |
| 4 | Speed Racer | - | - | - | $603,380 | 40 | $664,921 | May 8 | Warner Bros. | false |
| 5 | The Orphanage | - | - | - | $515,162 | 16 | $733,144 | May 1 | CDI Films | false |
| 6 | An American Haunting | - | - | - | $260,342 | 18 | $410,016 | Apr 17 | Bazuca Films | false |
| 7 | Charlie Wilson's War | - | - | - | $179,420 | 21 | $191,422 | May 8 | United International Pictures | false |
| 8 | 31 Minutos: La Película | - | - | - | $148,763 | 38 | $1,065,000 | Mar 27 | MC Film Dagitim | false |
| 9 | Lokas | - | - | - | $112,156 | 39 | $645,800 | Apr 3 | Andes Films | false |
| 10 | What Happens in Vegas | - | - | - | $100,664 | 25 | $375,070 | May 29 | 20th Century Fox International | false |
| 11 | Eastern Promises | - | - | - | $91,654 | 18 | $273,739 | Apr 10 | Bazuca Films | false |
| 12 | Shutter | - | - | - | $84,852 | 21 | $209,914 | Apr 17 | 20th Century Fox International | false |
| 13 | Meet the Spartans | - | - | - | $84,710 | 24 | $153,041 | Apr 24 | 20th Century Fox International | false |
| 14 | Vantage Point | - | - | - | $76,705 | 27 | $273,843 | Apr 10 | Sony Pictures Releasing | false |
| 15 | The Spiderwick Chronicles | - | - | - | $76,111 | 34 | $439,982 | Mar 20 | United International Pictures | false |
| 16 | Horton Hears a Who! | - | - | - | $55,689 | 41 | $629,280 | Mar 13 | 20th Century Fox International | false |
| 17 | August Rush | - | - | - | $53,751 | 18 | $53,751 | May 1 | Bazuca Films | false |
| 18 | Elizabeth: The Golden Age | - | - | - | $45,037 | 4 | $48,413 | May 15 | United International Pictures | false |
| 19 | U2 3D | - | - | - | $43,702 | 1 | $46,583 | May 1 | - | false |
| 20 | Lassie | - | - | - | $40,359 | 13 | $40,569 | May 1 | Bazuca Films | false |
| 21 | Two Days in Paris | - | - | - | $27,076 | 6 | $94,113 | May 29 | Impacto Cine | false |
| 22 | Bordertown | - | - | - | $25,693 | 12 | $25,693 | May 15 | Bazuca Films | false |
| 23 | Jumper | - | - | - | $24,117 | 40 | $394,341 | Mar 27 | 20th Century Fox International | false |
| 24 | The Eye | - | - | - | $22,584 | 19 | $105,678 | Apr 10 | United International Pictures | false |
| 25 | The Page Turner | - | - | - | $20,177 | 2 | $24,630 | May 9 | Four Films | false |
| 26 | P2 | - | - | - | $18,256 | 12 | $41,312 | May 29 | Bazuca Films | false |
| 27 | The Darjeeling Limited | - | - | - | $15,987 | 4 | $74,146 | Apr 3 | 20th Century Fox International | false |
| 28 | After the Wedding | - | - | - | $14,864 | 5 | $69,637 | Mar 27 | Transeuropa | false |
| 29 | Mansacue | - | - | - | $14,543 | 20 | $43,800 | Apr 24 | - | false |
| 30 | Mirageman | - | - | - | $11,855 | 29 | $390,003 | Mar 20 | Bazuca Films | false |
| 31 | Fool's Gold | - | - | - | $11,597 | 25 | $86,500 | Apr 10 | Warner Bros. | false |
| 32 | 10,000 BC | - | - | - | $5,978 | 39 | $1,222,724 | Mar 6 | Warner Bros. | false |
| 33 | The Game Plan | - | - | - | $5,271 | 22 | $943,428 | Jan 17 | Walt Disney Pictures | false |
| 34 | In the Valley of Elah | - | - | - | $4,531 | 15 | $179,931 | Mar 13 | Bazuca Films | false |
| 35 | Atonement | - | - | - | $4,414 | 14 | $271,072 | Feb 14 | United International Pictures | false |
| 36 | Rambo | - | - | - | $3,977 | 26 | $154,770 | Apr 3 | - | false |
| 37 | Whisper | - | - | - | $3,371 | 12 | $21,877 | Apr 24 | Transeuropa | false |
| 38 | The Bucket List | - | - | - | $1,002 | 19 | $518,715 | Jan 31 | Warner Bros. | false |
| 39 | P.S. I Love You | - | - | - | $872 | 19 | $307,491 | Feb 14 | Bazuca Films | false |
| 40 | The Water Horse | - | - | - | $783 | 26 | $600,376 | Feb 7 | Sony Pictures Releasing | false |
| 41 | Mr. Woodcock | - | - | - | $718 | 12 | $26,703 | Apr 17 | Bazuca Films | false |
| 42 | No Country for Old Men | - | - | - | $431 | 11 | $381,610 | Feb 14 | United International Pictures | false |
| 43 | The Flock | - | - | - | $111 | 13 | $25,066 | Apr 10 | CDI Films | false |
