| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $3,363,557 | 146 | $6,116,602 | May 21 | Universal Pictures International (UPI) | false |
| 2 | What Happens in Vegas | - | - | - | $1,805,623 | 73 | $2,400,166 | May 7 | 20th Century Fox International | false |
| 3 | Iron Man | - | - | - | $1,234,745 | 69 | $1,361,378 | Apr 30 | Universal Pictures International (UPI) | false |
| 4 | Sex and the City | - | - | - | $857,549 | 103 | $3,589,705 | May 28 | Warner Bros. | false |
| 5 | The Wave | - | - | - | $637,611 | 23 | $907,999 | May 1 | Rialto Distribution | false |
| 6 | Made of Honor | - | - | - | $566,006 | 42 | $244,603 | May 15 | Walt Disney Pictures | false |
| 7 | Welcome to the Sticks | - | - | - | $501,702 | 28 | $9,897,101 | Feb 27 | Pathé | false |
| 8 | Fool's Gold | - | - | - | $417,154 | 58 | $708,693 | Apr 24 | Warner Bros. | false |
| 9 | Step Up 2: The Streets | - | - | - | $310,993 | 53 | $3,351,591 | Mar 12 | Universal Pictures International (UPI) | false |
| 10 | The Game Plan | - | - | - | $249,635 | 28 | $413,001 | Apr 30 | Walt Disney Pictures | false |
| 11 | Street Kings | - | - | - | $225,796 | 34 | $766,903 | Apr 17 | 20th Century Fox International | false |
| 12 | Summer | - | - | - | $208,233 | 35 | $513,952 | Apr 17 | Walt Disney Pictures | false |
| 13 | 27 Dresses | - | - | - | $200,179 | 47 | $1,385,812 | Feb 14 | 20th Century Fox International | false |
| 14 | Cherry Blossoms | - | - | - | $171,442 | 15 | $763,780 | Mar 27 | Ascot Elite Entertainment Group | false |
| 15 | Once | - | - | - | $167,731 | 8 | $530,986 | Apr 10 | Ascot Elite Entertainment Group | false |
| 16 | The Other Boleyn Girl | - | - | - | $152,674 | 22 | $908,294 | Mar 6 | Universal Pictures International (UPI) | false |
| 17 | Shine a Light | - | - | - | $149,130 | 13 | $478,424 | Apr 16 | Filmcoopi Zürich | false |
| 18 | Horton Hears a Who! | - | - | - | $145,313 | 78 | $2,149,220 | Mar 13 | 20th Century Fox International | false |
| 19 | Goodbye Beautiful Days | - | - | - | $118,113 | 8 | $118,113 | Apr 30 | JMH Distribution | false |
| 20 | Nim's Island | - | - | - | $106,020 | 35 | $508,229 | Apr 9 | Ascot Elite Entertainment Group | false |
| 21 | Lemon Tree | - | - | - | $84,136 | 8 | $223,086 | Apr 30 | Agora Films | false |
| 22 | Cash | - | - | - | $74,906 | 7 | $129,140 | Apr 23 | Pathé | false |
| 23 | Days and Clouds | - | - | - | $73,333 | 10 | $451,278 | Nov 2 | Filmcoopi Zürich | false |
| 24 | The Drummer | - | - | - | $66,098 | 9 | $66,098 | May 15 | Filmcoopi Zürich | false |
| 25 | Vantage Point | - | - | - | $52,139 | 27 | $449,207 | Feb 28 | Walt Disney Pictures | false |
| 26 | Speed Racer | - | - | - | $50,568 | 53 | $67,752 | May 8 | Warner Bros. | false |
| 27 | Juno | - | - | - | $34,808 | 34 | $1,746,565 | Feb 6 | 20th Century Fox International | false |
| 28 | A Christmas Tale | - | - | - | $30,806 | 11 | $86,038 | May 21 | JMH Distribution | false |
| 29 | No Country for Old Men | - | - | - | $29,642 | 38 | $2,258,973 | Jan 23 | Universal Pictures International (UPI) | false |
| 30 | Untraceable | - | - | - | $28,927 | 21 | $534,433 | Mar 5 | Universal Pictures International (UPI) | false |
| 31 | Quiet Chaos | - | - | - | $26,672 | 9 | $114,536 | Feb 29 | Filmcoopi Zürich | false |
| 32 | Superhero Movie | - | - | - | $21,604 | 30 | $391,167 | May 16 | Ascot Elite Entertainment Group | false |
| 33 | The Kite Runner | - | - | - | $19,968 | 33 | $3,312,635 | Jan 17 | Universal Pictures International (UPI) | false |
| 34 | Non pensarci | - | - | - | $12,210 | 5 | $172,791 | Apr 4 | Xenix Filmdistribution | false |
| 35 | Zu Fuss nach Santiago de Compostela | - | - | - | $11,109 | 12 | $363,496 | Nov 1 | Frenetic Films | false |
| 36 | The Spiderwick Chronicles | - | - | - | $6,928 | 41 | $433,761 | Mar 19 | Universal Pictures International (UPI) | false |
| 37 | Definitely, Maybe | - | - | - | $6,413 | 22 | $491,033 | Mar 27 | Universal Pictures International (UPI) | false |
| 38 | The Water Horse | - | - | - | $1,073 | 17 | $323,758 | Jan 31 | Walt Disney Pictures | false |
