| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $2,884,260 | 103 | $5,983,284 | May 21 | Universal Pictures International (UPI) | false |
| 2 | Iron Man | - | - | - | $1,679,066 | 54 | $1,970,548 | Apr 30 | Universal Pictures International (UPI) | false |
| 3 | What Happens in Vegas | - | - | - | $1,435,418 | 50 | $2,268,743 | May 7 | 20th Century Fox International | false |
| 4 | Welcome to the Sticks | - | - | - | $642,956 | 64 | $10,746,995 | Feb 27 | Alternative Films | false |
| 5 | 21 | - | - | - | $612,464 | 41 | $1,408,885 | Apr 16 | Sony Pictures Releasing | false |
| 6 | Fool's Gold | - | - | - | $477,170 | 25 | $553,082 | Apr 30 | Warner Bros. | false |
| 7 | Nim's Island | - | - | - | $449,191 | 66 | $620,611 | Apr 30 | Belga Films | false |
| 8 | Street Kings | - | - | - | $413,811 | 30 | $610,305 | May 14 | 20th Century Fox International | false |
| 9 | The Mist | - | - | - | $324,237 | 23 | $587,258 | Apr 23 | Benelux Film Distributors | false |
| 10 | Taken | - | - | - | $294,820 | 30 | $680,286 | Apr 16 | Belga Films | false |
| 11 | The Other Boleyn Girl | - | - | - | $264,281 | 38 | $892,458 | Apr 9 | Universal Pictures International (UPI) | false |
| 12 | Horton Hears a Who! | - | - | - | $264,075 | 125 | $2,756,850 | Mar 19 | 20th Century Fox International | false |
| 13 | Cash | - | - | - | $247,917 | 20 | $395,143 | Apr 23 | Belga Films | false |
| 14 | Mongol: The Rise of Genghis Khan | - | - | - | $139,638 | 12 | $225,998 | May 7 | Benelux Film Distributors | false |
| 15 | 10,000 BC | - | - | - | $137,027 | 60 | $2,442,136 | Mar 12 | Warner Bros. | false |
| 16 | REC | - | - | - | $129,303 | 12 | $149,676 | Apr 30 | Paradiso Entertainment | false |
| 17 | The Spiderwick Chronicles | - | - | - | $119,460 | 58 | $1,638,189 | Mar 19 | Universal Pictures International (UPI) | false |
| 18 | U2 3D | - | - | - | $108,284 | 13 | $393,906 | Apr 9 | Kinepolis Film Distribution (KFD) | false |
| 19 | Doomsday | - | - | - | $105,485 | 15 | $134,257 | May 7 | Kinepolis Film Distribution (KFD) | false |
| 20 | Moscow, Belgium | - | - | - | $104,929 | 20 | $1,898,002 | Jan 30 | Kinepolis Film Distribution (KFD) | false |
| 21 | Hotel op stelten | - | - | - | $104,075 | 38 | $1,258,387 | Mar 12 | Kinepolis Film Distribution (KFD) | false |
| 22 | Over Her Dead Body | - | - | - | $102,346 | 12 | $234,293 | May 21 | Kinepolis Film Distribution (KFD) | false |
| 23 | The Eye | - | - | - | $97,903 | 26 | $489,462 | Apr 9 | Kinepolis Film Distribution (KFD) | false |
| 24 | Meet the Spartans | - | - | - | $89,543 | 40 | $799,917 | Apr 2 | 20th Century Fox International | false |
| 25 | Definitely, Maybe | - | - | - | $77,975 | 23 | $138,908 | May 7 | Universal Pictures International (UPI) | false |
| 26 | I've Loved You So Long | - | - | - | $73,451 | 23 | $549,993 | Mar 19 | Benelux Film Distributors | false |
| 27 | Winx Club: The Secret of the Lost Kingdom | - | - | - | $72,138 | 28 | $608,596 | Mar 26 | Independent Films | false |
| 28 | Disco | - | - | - | $71,024 | 21 | $833,837 | Apr 2 | Universal Pictures International (UPI) | false |
| 29 | The Band's Visit | - | - | - | $68,899 | 9 | $144,108 | Apr 23 | Paradiso Entertainment | false |
| 30 | Love in the Time of Cholera | - | - | - | $67,130 | 18 | $106,811 | Apr 30 | Cinéart | false |
| 31 | Funny Games | - | - | - | $63,381 | 26 | $202,177 | Apr 16 | Cinéart | false |
| 32 | Step Up 2: The Streets | - | - | - | $61,920 | 47 | $3,434,617 | Feb 27 | Benelux Film Distributors | false |
| 33 | Untraceable | - | - | - | $61,120 | 26 | $1,061,789 | Mar 5 | Kinepolis Film Distribution (KFD) | false |
| 34 | The Great Alibi | - | - | - | $60,691 | 8 | $68,513 | May 7 | Les Films de l'Elysée | false |
| 35 | The Ruins | - | - | - | $60,271 | 25 | $225,485 | Apr 16 | Universal Pictures International (UPI) | false |
| 36 | 3:10 to Yuma | - | - | - | $57,227 | 12 | $207,277 | May 28 | Benelux Film Distributors | false |
| 37 | Fly Me to the Moon 3D | - | - | - | $51,941 | 14 | $1,184,962 | Jan 30 | Kinepolis Film Distribution (KFD) | false |
| 38 | 120 | - | - | - | $47,791 | 3 | $47,791 | May 7 | - | false |
| 39 | Lemon Tree | - | - | - | $46,575 | 11 | $133,785 | May 21 | Cinéart | false |
| 40 | There Will Be Blood | - | - | - | $45,692 | 10 | $675,721 | Feb 20 | Walt Disney Pictures | false |
| 41 | Never Back Down | - | - | - | $39,072 | 17 | $97,339 | Apr 23 | Paradiso Entertainment | false |
| 42 | Dragon Hunters | - | - | - | $36,663 | 41 | $402,591 | Mar 26 | Belga Films | false |
| 43 | Linkeroever | - | - | - | $34,433 | 12 | $372,486 | Mar 26 | Kinepolis Film Distribution (KFD) | false |
| 44 | Vantage Point | - | - | - | $32,449 | 41 | $932,450 | Mar 26 | Sony Pictures Releasing | false |
| 45 | Julia | - | - | - | $32,416 | 8 | $38,697 | May 7 | Cinéart | false |
| 46 | Les randonneurs à Saint-Tropez | - | - | - | $32,123 | 25 | $316,657 | Apr 9 | Belga Films | false |
| 47 | No Country for Old Men | - | - | - | $30,790 | 35 | $1,894,104 | Jan 23 | Universal Pictures International (UPI) | false |
| 48 | In Memory of Me | - | - | - | $21,977 | 6 | $27,242 | May 14 | Cinéart | false |
| 49 | Tu peux garder un secret? | - | - | - | $21,316 | 5 | $23,009 | May 14 | Les Films de l'Elysée | false |
| 50 | The Kite Runner | - | - | - | $18,673 | 30 | $825,176 | Feb 13 | Universal Pictures International (UPI) | false |
| 51 | The Game Plan | - | - | - | $18,295 | 37 | $472,512 | Mar 26 | Walt Disney Pictures | false |
| 52 | Days and Clouds | - | - | - | $15,544 | 6 | $32,168 | May 21 | ABC Distribution | false |
| 53 | How She Move | - | - | - | $14,932 | 4 | $39,376 | May 28 | Universal Pictures International (UPI) | false |
| 54 | The New Protocol | - | - | - | $14,917 | 14 | $24,513 | May 28 | Cinéart | false |
| 55 | 27 Dresses | - | - | - | $14,566 | 55 | $1,167,226 | Mar 5 | 20th Century Fox International | false |
| 56 | A Simple Heart | - | - | - | $14,093 | 2 | $27,260 | Apr 30 | Les Films de l'Elysée | false |
| 57 | Shine a Light | - | - | - | $12,548 | 7 | $66,185 | May 28 | Kinepolis Film Distribution (KFD) | false |
| 58 | Resurrecting the Champ | - | - | - | $12,210 | 8 | $13,221 | May 14 | Belga Films | false |
| 59 | Formidable | - | - | - | $11,662 | 5 | $11,662 | Apr 30 | Kinepolis Film Distribution (KFD) | false |
| 60 | The Darjeeling Limited | - | - | - | $9,284 | 12 | $224,733 | Mar 19 | 20th Century Fox International | false |
| 61 | The Bucket List | - | - | - | $9,152 | 35 | $586,727 | Mar 5 | Warner Bros. | false |
| 62 | Bhoothnath | - | - | - | $7,205 | 1 | $7,205 | May 7 | - | false |
| 63 | Mr. Magorium's Wonder Emporium | - | - | - | $5,953 | 29 | $350,117 | Dec 26 | Benelux Film Distributors | false |
| 64 | Juno | - | - | - | $5,953 | 30 | $1,052,164 | Feb 6 | 20th Century Fox International | false |
| 65 | Delirious | - | - | - | $5,729 | 2 | $5,729 | May 21 | - | false |
| 66 | Once | - | - | - | $4,806 | 5 | $44,298 | Mar 5 | Paradiso Entertainment | false |
| 67 | The Home Song Stories | - | - | - | $3,861 | 3 | $4,057 | May 14 | Paradiso Entertainment | false |
| 68 | The Year My Parents Went on Vacation | - | - | - | $3,407 | 8 | $61,062 | Apr 2 | Cinéart | false |
| 69 | Redacted | - | - | - | $1,934 | 3 | $17,223 | Feb 27 | Paradiso Entertainment | false |
| 70 | Lou Reed's Berlin | - | - | - | $1,908 | 1 | $2,863 | Apr 30 | Paradiso Entertainment | false |
| 71 | Counterparts | - | - | - | $1,616 | 3 | $1,616 | May 28 | - | false |
| 72 | Munyurangabo | - | - | - | $658 | 1 | $658 | May 21 | - | false |
| 73 | 1408 | - | - | - | $645 | 33 | $796,442 | Oct 3 | Benelux Film Distributors | false |
| 74 | Import Export | - | - | - | $542 | 3 | $12,539 | Mar 5 | Benelux Film Distributors | false |
| 75 | The Feelings Factory | - | - | - | $483 | 5 | $46,721 | Feb 20 | Benelux Film Distributors | false |
| 76 | Rescue Dawn | - | - | - | $176 | 1 | $4,823 | Apr 9 | - | false |
| 77 | California Dreamin' | - | - | - | $99 | 7 | $35,689 | Jan 9 | Benelux Film Distributors | false |
