| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $17,331,069 | 535 | $27,159,421 | May 22 | Paramount Pictures International | false |
| 2 | Iron Man | - | - | - | $17,185,852 | 365 | $19,087,903 | May 1 | Paramount Pictures International | false |
| 3 | What Happens in Vegas | - | - | - | $7,987,325 | 335 | $9,625,030 | May 8 | 20th Century Fox International | false |
| 4 | Made of Honor | - | - | - | $4,880,827 | 256 | $5,095,762 | May 1 | Sony Pictures Releasing | false |
| 5 | 21 | - | - | - | $3,662,464 | 191 | $4,703,670 | May 15 | Sony Pictures Releasing | false |
| 6 | Forgetting Sarah Marshall | - | - | - | $2,013,777 | 255 | $6,456,024 | Apr 17 | Universal Pictures International (UPI) | false |
| 7 | The Painted Veil | - | - | - | $1,629,947 | 63 | $3,453,372 | Apr 24 | Paramount Pictures International | false |
| 8 | Shutter | - | - | - | $1,040,124 | 74 | $1,269,976 | May 15 | 20th Century Fox International | false |
| 9 | Then She Found Me | - | - | - | $994,390 | 55 | $1,438,126 | May 15 | Hopscotch Films | false |
| 10 | Horton Hears a Who! | - | - | - | $961,579 | 363 | $11,262,758 | Mar 20 | 20th Century Fox International | false |
| 11 | Miss Pettigrew Lives for a Day | - | - | - | $907,720 | 71 | $1,089,700 | May 8 | Roadshow Films | false |
| 12 | Street Kings | - | - | - | $777,659 | 222 | $3,878,910 | Apr 17 | 20th Century Fox International | false |
| 13 | The Counterfeiters | - | - | - | $757,231 | 37 | $1,296,678 | May 8 | Madman Entertainment | false |
| 14 | Nim's Island | - | - | - | $704,938 | 196 | $5,819,517 | Apr 3 | Universal Pictures International (UPI) | false |
| 15 | Deception | - | - | - | $670,072 | 112 | $1,447,588 | Apr 24 | 20th Century Fox International | false |
| 16 | Gone Baby Gone | - | - | - | $560,270 | 40 | $1,310,611 | Apr 17 | Walt Disney Pictures | false |
| 17 | Lars and the Real Girl | - | - | - | $449,602 | 39 | $1,398,865 | Apr 3 | Rialto Distribution | false |
| 18 | Untraceable | - | - | - | $396,613 | 122 | $1,020,322 | Apr 24 | Universal Pictures International (UPI) | false |
| 19 | The Edge of Heaven | - | - | - | $351,500 | 17 | $684,381 | Apr 24 | Sharmill Films | false |
| 20 | U2 3D | - | - | - | $349,537 | 23 | $990,192 | Apr 10 | Roadshow Films | false |
| 21 | Molière | - | - | - | $329,342 | 35 | $382,847 | May 1 | Hopscotch Films | false |
| 22 | Step Up 2: The Streets | - | - | - | $305,398 | 188 | $8,657,437 | Mar 20 | Universal Pictures International (UPI) | false |
| 23 | The Spiderwick Chronicles | - | - | - | $278,128 | 269 | $7,350,921 | Apr 3 | Paramount Pictures International | false |
| 24 | A Secret | - | - | - | $251,653 | 25 | $547,835 | May 15 | Icon Film Distribution Australia | false |
| 25 | Playground | - | - | - | $235,776 | 3 | $250,155 | May 21 | - | false |
| 26 | The Black Balloon | - | - | - | $233,198 | 76 | $2,105,473 | Mar 6 | Icon Film Distribution Australia | false |
| 27 | Superhero Movie | - | - | - | $230,705 | 188 | $3,220,326 | Apr 10 | Roadshow Films | false |
| 28 | Before the Devil Knows You're Dead | - | - | - | $206,512 | 46 | $1,539,246 | Mar 20 | Hopscotch Films | false |
| 29 | Smart People | - | - | - | $203,633 | 132 | $669,238 | Apr 24 | Icon Film Distribution Australia | false |
| 30 | The Bucket List | - | - | - | $203,495 | 256 | $7,385,515 | Feb 21 | Warner Bros. | false |
| 31 | Prom Night | - | - | - | $188,612 | 124 | $2,566,794 | Apr 10 | Sony Pictures Releasing | false |
| 32 | The Other Boleyn Girl | - | - | - | $185,629 | 132 | $3,792,878 | Mar 13 | Universal Pictures International (UPI) | false |
| 33 | Smother | - | - | - | $170,905 | 135 | $171,217 | May 8 | Hoyts Distribution | false |
| 34 | 10,000 BC | - | - | - | $166,579 | 221 | $6,276,216 | Mar 6 | Warner Bros. | false |
| 35 | Love in the Time of Cholera | - | - | - | $163,554 | 49 | $205,747 | May 22 | Rialto Distribution | false |
| 36 | Paris | - | - | - | $155,921 | 30 | $694,134 | Apr 10 | Icon Film Distribution Australia | false |
| 37 | Semi-Pro | - | - | - | $152,878 | 202 | $3,890,603 | Apr 3 | Roadshow Films | false |
| 38 | Shine a Light | - | - | - | $134,738 | 28 | $871,598 | May 29 | 20th Century Fox International | false |
| 39 | Sharkwater | - | - | - | $119,183 | 42 | $144,242 | May 15 | Walt Disney Pictures | false |
| 40 | The Orphanage | - | - | - | $116,394 | 21 | $633,721 | May 29 | Roadshow Films | false |
| 41 | Cactus | - | - | - | $114,957 | 40 | $151,184 | May 1 | Hoyts Distribution | false |
| 42 | Never Back Down | - | - | - | $96,392 | 151 | $3,055,171 | Mar 27 | Roadshow Films | false |
| 43 | Leatherheads | - | - | - | $86,446 | 40 | $185,755 | May 29 | Universal Pictures International (UPI) | false |
| 44 | Run Fatboy Run | - | - | - | $80,225 | 238 | $3,196,789 | Mar 6 | Roadshow Films | false |
| 45 | Bhoothnath | - | - | - | $54,372 | 8 | $54,372 | May 8 | Eros Worldwide | false |
| 46 | Brick Lane | - | - | - | $52,597 | 25 | $629,347 | Mar 20 | Madman Entertainment | false |
| 47 | Be Kind Rewind | - | - | - | $52,058 | 42 | $920,837 | Mar 20 | Roadshow Films | false |
| 48 | Black Water | - | - | - | $50,038 | 12 | $98,901 | Apr 24 | All Interactive Distribution | false |
| 49 | Closing the Ring | - | - | - | $42,834 | 54 | $385,671 | Mar 6 | Hopscotch Films | false |
| 50 | Goal II: Living the Dream | - | - | - | $38,700 | 41 | $42,355 | May 22 | Roadshow Films | false |
| 51 | In the Valley of Elah | - | - | - | $28,553 | 44 | $572,768 | Feb 28 | Hoyts Distribution | false |
| 52 | Two Days in Paris | - | - | - | $26,683 | 37 | $1,724,376 | Dec 26 | Hopscotch Films | false |
| 53 | In the Shadow of the Moon | - | - | - | $22,702 | 19 | $376,147 | Mar 6 | Madman Entertainment | false |
| 54 | Captivity | - | - | - | $21,561 | 42 | $21,561 | May 8 | Roadshow Films | false |
| 55 | 120 | - | - | - | $21,392 | 2 | $54,243 | Apr 10 | - | false |
| 56 | St. Trinian's | - | - | - | $18,764 | 209 | $2,508,880 | Mar 27 | Sony Pictures Releasing | false |
| 57 | Earth | - | - | - | $16,079 | 5 | $92,555 | May 29 | Hoyts Distribution | false |
| 58 | Flight of the Red Balloon | - | - | - | $13,065 | 6 | $172,859 | May 29 | Madman Entertainment | false |
| 59 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $6,862 | 20 | $1,204,893 | Mar 20 | Walt Disney Pictures | false |
| 60 | The Ten Commandments | - | - | - | $5,818 | 31 | $56,355 | Apr 24 | IDT Home Entertainment | false |
| 61 | Silk | - | - | - | $4,820 | 41 | $4,820 | May 1 | Roadshow Films | false |
| 62 | U Me Aur Hum | - | - | - | $4,411 | 8 | $135,607 | Apr 10 | Eros Worldwide | false |
| 63 | No Country for Old Men | - | - | - | $2,109 | 85 | $5,625,870 | - | Paramount Pictures International | false |
| 64 | The Secret of the Grain | - | - | - | $2,101 | 14 | $360,950 | Mar 20 | Palace Films | false |
| 65 | Juno | - | - | - | $2,006 | 197 | $10,951,850 | Jan 17 | Walt Disney Studios Motion Pictures | false |
| 66 | Am Limit | - | - | - | $1,709 | 1 | $1,709 | May 1 | - | false |
| 67 | Tashan | - | - | - | $1,319 | 13 | $222,019 | Apr 24 | MG Distribution | false |
| 68 | Bella | - | - | - | $903 | 21 | $199,690 | Feb 21 | Hopscotch Films | false |
| 69 | Grand Canyon Adventure: River at Risk | - | - | - | $559 | 1 | $402,239 | Jun 19 | IMAX | false |
| 70 | Broken Sun | - | - | - | $488 | 2 | $4,799 | Apr 24 | JackaFilms | false |
| 71 | Paranoid Park | - | - | - | $333 | 5 | $71,749 | Mar 6 | Madman Entertainment | false |
| 72 | Grindhouse | - | - | - | $314 | 2 | $109,275 | Dec 13 | Roadshow Films | false |
