| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $1,714,542 | 141 | $3,007,401 | May 22 | United International Pictures | false |
| 2 | Speed Racer | - | - | - | $1,703,400 | 94 | $2,044,203 | May 8 | Warner Bros. | false |
| 3 | Iron Man | - | - | - | $1,370,632 | 82 | $1,606,400 | Apr 30 | United International Pictures | false |
| 4 | Death at a Funeral | - | - | - | $697,008 | 33 | $2,153,078 | Mar 6 | Compañía General de la Imagen (CGI) | false |
| 5 | The Nest | - | - | - | $623,088 | 39 | $1,008,755 | Apr 24 | Distribution Company | false |
| 6 | What Happens in Vegas | - | - | - | $448,138 | 30 | $790,709 | May 15 | 20th Century Fox International | false |
| 7 | The Oxford Murders | - | - | - | $417,674 | 23 | $589,788 | May 8 | Pachamama Cine | false |
| 8 | 21 | - | - | - | $358,835 | 57 | $737,889 | Apr 17 | Sony Pictures Releasing | false |
| 9 | Shutter | - | - | - | $262,458 | 33 | $506,762 | Apr 17 | 20th Century Fox International | false |
| 10 | The Counterfeiters | - | - | - | $255,894 | 22 | $398,205 | May 15 | Alfa Films | false |
| 11 | Awake | - | - | - | $208,525 | 31 | $274,878 | May 15 | Distribution Company | false |
| 12 | Street Kings | - | - | - | $136,645 | 37 | $249,414 | Apr 24 | 20th Century Fox International | false |
| 13 | Conversations with My Gardener | - | - | - | $130,936 | 14 | $221,688 | Apr 24 | Alfa Films | false |
| 14 | Lamb of God | - | - | - | $128,211 | 13 | $144,627 | May 8 | Alfa Films | false |
| 15 | 88 Minutes | - | - | - | $116,400 | 31 | $396,117 | May 29 | Distribution Company | false |
| 16 | Untraceable | - | - | - | $115,887 | 29 | $203,169 | Apr 24 | Sony Pictures Releasing | false |
| 17 | The Unknown Woman | - | - | - | $115,265 | 19 | $182,369 | May 22 | Impacto Cine | false |
| 18 | 10,000 BC | - | - | - | $112,047 | 76 | $2,262,479 | Mar 6 | Warner Bros. | false |
| 19 | The Savages | - | - | - | $111,148 | 16 | $120,051 | May 1 | 20th Century Fox International | false |
| 20 | Horton Hears a Who! | - | - | - | $103,074 | 105 | $1,253,165 | Mar 13 | 20th Century Fox International | false |
| 21 | Leonera | - | - | - | $91,258 | 30 | $486,380 | May 29 | Walt Disney Pictures | false |
| 22 | The Orphanage | - | - | - | $86,764 | 35 | $752,899 | Mar 13 | CDI Films | false |
| 23 | We Own the Night | - | - | - | $83,213 | 17 | $87,020 | May 1 | CDI Films | false |
| 24 | Enchanted | - | - | - | $70,131 | 108 | $2,862,455 | Jan 3 | Walt Disney Pictures | false |
| 25 | The Game Plan | - | - | - | $67,514 | 58 | $1,519,256 | Feb 14 | Walt Disney Pictures | false |
| 26 | In the Valley of Elah | - | - | - | $66,226 | 15 | $337,252 | Apr 3 | Alfa Films | false |
| 27 | Jumper | - | - | - | $66,174 | 62 | $641,845 | Apr 3 | 20th Century Fox International | false |
| 28 | The Bucket List | - | - | - | $62,174 | 70 | $1,982,902 | Feb 7 | Warner Bros. | false |
| 29 | Lust, Caution | - | - | - | $59,722 | 18 | $60,943 | May 1 | Distribution Company | false |
| 30 | The Spiderwick Chronicles | - | - | - | $56,700 | 54 | $694,010 | Mar 20 | United International Pictures | false |
| 31 | P.S. I Love You | - | - | - | $55,655 | 29 | $463,222 | Feb 28 | Alfa Films | false |
| 32 | Two Days in Paris | - | - | - | $52,383 | 19 | $373,612 | Mar 27 | Impacto Cine | false |
| 33 | Evening | - | - | - | $52,313 | 21 | $193,691 | Apr 10 | Impacto Cine | false |
| 34 | Mrs Palfrey at the Claremont 2008 Re-release | - | - | - | $47,175 | 4 | $88,099 | May 15 | Primer Plano Film Group | false |
| 35 | No Country for Old Men | - | - | - | $44,068 | 52 | $1,002,429 | Mar 6 | Walt Disney Pictures | false |
| 36 | National Treasure: Book of Secrets | - | - | - | $41,322 | 90 | $1,701,941 | Jan 17 | Walt Disney Pictures | false |
| 37 | The Golden Compass | - | - | - | $35,152 | 84 | $1,421,819 | Dec 13 | Distribution Company | false |
| 38 | Yo soy sola | - | - | - | $34,174 | 10 | $38,523 | May 15 | Alfa Films | false |
| 39 | Persepolis | - | - | - | $31,439 | 4 | $43,912 | Apr 24 | Sony Pictures Releasing | false |
| 40 | Caramel | - | - | - | $25,810 | 13 | $232,704 | Mar 27 | Alfa Films | false |
| 41 | Twice Upon a Time | - | - | - | $22,751 | 18 | $110,611 | Apr 17 | Pachamama Cine | false |
| 42 | Love by Accident | - | - | - | $22,510 | 18 | $39,247 | May 29 | Primer Plano Film Group | false |
| 43 | Underdog | - | - | - | $21,249 | 46 | $886,546 | Oct 4 | Walt Disney Pictures | false |
| 44 | Alvin and the Chipmunks | - | - | - | $20,960 | 69 | $833,808 | Jan 3 | 20th Century Fox International | false |
| 45 | Elizabeth: The Golden Age | - | - | - | $18,972 | 13 | $110,682 | Mar 13 | United International Pictures | false |
| 46 | Odette Toulemonde | - | - | - | $17,652 | 8 | $30,472 | May 29 | Notro Films | false |
| 47 | The Hunting Party | - | - | - | $15,952 | 34 | $317,644 | Mar 20 | Distribution Company | false |
| 48 | Mr. Woodcock | - | - | - | $14,637 | 23 | $106,745 | Apr 3 | Distribution Company | false |
| 49 | Diary of the Dead | - | - | - | $13,687 | 31 | $296,292 | Mar 20 | Pachamama Cine | false |
| 50 | Elite Squad | - | - | - | $12,851 | 18 | $106,643 | Apr 3 | United International Pictures | false |
| 51 | Bee Movie | - | - | - | $12,118 | 101 | $1,481,104 | Dec 6 | United International Pictures | false |
| 52 | King of California | - | - | - | $12,096 | 25 | $72,016 | Apr 10 | Distribution Company | false |
| 53 | Silk | - | - | - | $10,837 | 5 | $11,485 | May 8 | Distribution Company | false |
| 54 | Vantage Point | - | - | - | $8,876 | 46 | $387,184 | Feb 28 | Sony Pictures Releasing | false |
| 55 | 1408 | - | - | - | $8,200 | 37 | $262,789 | Jan 24 | United International Pictures | false |
| 56 | S.O.S. Ex | - | - | - | $7,974 | 3 | $8,731 | May 15 | - | false |
| 57 | El desierto negro | - | - | - | $7,232 | 2 | $7,232 | May 15 | - | false |
| 58 | The Ugly Duckling and Me! | - | - | - | $6,664 | 54 | $79,897 | Mar 20 | - | false |
| 59 | The Nanny Diaries | - | - | - | $5,556 | 33 | $70,408 | Apr 17 | Alfa Films | false |
| 60 | Rancho aparte | - | - | - | $4,260 | 32 | $138,524 | Mar 27 | Dream Company | false |
| 61 | Rain | - | - | - | $3,913 | 31 | $164,286 | Mar 20 | Walt Disney Pictures | false |
| 62 | The Eye | - | - | - | $3,530 | 24 | $229,916 | Feb 28 | United International Pictures | false |
| 63 | Winter Visitor | - | - | - | $3,290 | 26 | $34,155 | Apr 3 | Primer Plano Film Group | false |
| 64 | Shine a Light | - | - | - | $3,180 | 33 | $99,576 | Apr 10 | Distribution Company | false |
| 65 | Offside | - | - | - | $2,934 | 3 | $2,934 | May 1 | 791 Cine | false |
| 66 | The Darjeeling Limited | - | - | - | $2,882 | 14 | $118,402 | Mar 20 | 20th Century Fox International | false |
| 67 | The Water Horse | - | - | - | $2,571 | 38 | $590,991 | Feb 7 | Sony Pictures Releasing | false |
| 68 | La orilla que se abisma | - | - | - | $2,486 | 2 | $2,486 | May 1 | Primer Plano Film Group | false |
| 69 | Fool's Gold | - | - | - | $1,956 | 22 | $131,484 | Feb 28 | Warner Bros. | false |
| 70 | There Will Be Blood | - | - | - | $1,778 | 36 | $520,135 | Feb 21 | Walt Disney Pictures | false |
| 71 | Juno | - | - | - | $1,529 | 41 | $474,042 | Feb 14 | Alfa Films | false |
| 72 | Rambo | - | - | - | $1,503 | 49 | $324,433 | Feb 21 | CDI Films | false |
| 73 | Construcción de una ciudad | - | - | - | $1,483 | 2 | $1,483 | May 1 | - | false |
| 74 | The Mourning Forest | - | - | - | $1,294 | 3 | $5,786 | Apr 24 | CDI Films | false |
| 75 | I Could Never Be Your Woman | - | - | - | $1,226 | 34 | $302,572 | Jan 3 | CDI Films | false |
| 76 | 3:10 to Yuma | - | - | - | $1,136 | 32 | $276,073 | Feb 28 | Distribution Company | false |
| 77 | Hannibal Rising | - | - | - | $1,107 | 27 | $89,287 | Feb 21 | United International Pictures | false |
| 78 | Atonement | - | - | - | $769 | 43 | $533,834 | Feb 7 | United International Pictures | false |
| 79 | The Bothersome Man | - | - | - | $688 | 4 | $7,986 | Apr 10 | IFA | false |
| 80 | Beowulf | - | - | - | $609 | 47 | $904,033 | Nov 22 | Warner Bros. | false |
| 81 | D-Graduated | - | - | - | $514 | 3 | $15,004 | Mar 27 | Distribution Company | false |
| 82 | Bridge to Terabithia | - | - | - | $500 | 36 | $101,169 | Jan 10 | United International Pictures | false |
| 83 | Evita, otra mirada | - | - | - | $477 | 1 | $477 | May 1 | - | false |
| 84 | Explosive Brigade: Pirate Mission | - | - | - | $363 | 96 | $763,987 | Feb 1 | Argentina Sono Film S.A.C.I. | false |
| 85 | The Dog Pound | - | - | - | $359 | 4 | $4,825 | Apr 18 | Primer Plano Film Group | false |
| 86 | U2 3D | - | - | - | $292 | 1 | $140,453 | Mar 27 | IMAX | false |
| 87 | Olga, Victoria Olga | - | - | - | $208 | 3 | $3,192 | Apr 4 | - | false |
| 88 | Sweeney Todd: The Demon Barber of Fleet Street | - | - | - | $208 | 46 | $651,305 | Feb 14 | Warner Bros. | false |
| 89 | Private Property | - | - | - | $129 | 5 | $28,970 | Mar 20 | Alfa Films | false |
| 90 | Happy Feet | - | - | - | $71 | 132 | $1,378,012 | Dec 7 | Warner Bros. | false |
| 91 | Night at the Museum | - | - | - | $66 | 92 | $3,216,799 | Jan 18 | 20th Century Fox International | false |
| 92 | Martín Fierro, el ave solitaria | - | - | - | $59 | 21 | $154,324 | Jun 22 | Cinemagroup | false |
| 93 | Possible Lives | - | - | - | $40 | 5 | $19,236 | Feb 7 | Primer Plano Film Group | false |
