| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Iron Man | - | - | - | $1,717,341 | 34 | $1,841,925 | May 1 | - | false |
| 2 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $1,188,439 | 36 | $1,496,148 | May 22 | - | false |
| 3 | The Forbidden Kingdom | - | - | - | $658,625 | 26 | $1,252,955 | May 29 | - | false |
| 4 | What Happens in Vegas | - | - | - | $568,788 | 19 | $698,672 | May 15 | - | false |
| 5 | Step Up 2: The Streets | - | - | - | $404,697 | 18 | $408,436 | May 1 | - | false |
| 6 | Untraceable | - | - | - | $343,460 | 16 | $351,996 | May 8 | - | false |
| 7 | Nim's Island | - | - | - | $239,464 | 18 | $266,237 | May 15 | - | false |
| 8 | Made of Honor | - | - | - | $214,306 | 16 | $214,306 | May 1 | - | false |
| 9 | 21 | - | - | - | $170,626 | 19 | $480,410 | Apr 24 | - | false |
| 10 | College Road Trip | - | - | - | $154,549 | 19 | $378,784 | Apr 24 | - | false |
| 11 | Prom Night | - | - | - | $140,982 | 17 | $237,319 | May 29 | - | false |
| 12 | Speed Racer | - | - | - | $140,200 | 19 | $140,200 | May 8 | - | false |
| 13 | Outlaw | - | - | - | $110,574 | 16 | $110,574 | May 15 | - | false |
| 14 | Taymour W Shafika | - | - | - | $107,647 | 8 | $117,183 | May 15 | - | false |
| 15 | Morgan Ahmed Morgan | - | - | - | $87,851 | 19 | $696,949 | Apr 10 | - | false |
| 16 | The Night Listener | - | - | - | $73,083 | 16 | $74,140 | May 15 | - | false |
| 17 | The Other Boleyn Girl | - | - | - | $64,824 | 9 | $64,824 | May 8 | - | false |
| 18 | Stop-Loss | - | - | - | $55,511 | 18 | $55,511 | May 8 | - | false |
| 19 | Before the Devil Knows You're Dead | - | - | - | $50,225 | 10 | $50,225 | May 8 | - | false |
| 20 | King of California | - | - | - | $41,360 | 14 | $43,850 | May 22 | - | false |
| 21 | Miss Pettigrew Lives for a Day | - | - | - | $37,364 | 8 | $40,644 | May 22 | - | false |
| 22 | The Ferryman | - | - | - | $22,360 | 13 | $124,278 | Apr 24 | - | false |
| 23 | Ana Mesh Maahom | - | - | - | $21,360 | 14 | $21,360 | May 1 | - | false |
| 24 | Rescue Dawn | - | - | - | $19,719 | 18 | $133,770 | Apr 24 | - | false |
| 25 | The Spiderwick Chronicles | - | - | - | $19,272 | 19 | $372,671 | Mar 20 | - | false |
| 26 | Horton Hears a Who! | - | - | - | $19,233 | 19 | $444,414 | Mar 20 | - | false |
| 27 | Leabet el hob | - | - | - | $19,024 | 15 | $26,096 | May 22 | - | false |
| 28 | Agamista | - | - | - | $15,475 | 18 | $15,475 | May 29 | - | false |
| 29 | Mad Money | - | - | - | $14,837 | 18 | $268,191 | Apr 17 | - | false |
| 30 | Chrysalis | - | - | - | $12,824 | 8 | $12,824 | May 15 | - | false |
| 31 | The Pirates Who Don't Do Anything: A VeggieTales Movie | - | - | - | $12,267 | 17 | $50,430 | Apr 24 | - | false |
| 32 | Street Kings | - | - | - | $12,033 | 19 | $326,101 | Apr 17 | - | false |
| 33 | Kamel El Awsaf | - | - | - | $10,124 | 9 | $10,124 | May 8 | - | false |
| 34 | St. Trinian's | - | - | - | $5,838 | 5 | $5,838 | May 1 | - | false |
| 35 | Drillbit Taylor | - | - | - | $4,378 | 18 | $238,647 | Apr 10 | - | false |
| 36 | Fool's Gold | - | - | - | $3,482 | 18 | $448,458 | Apr 3 | - | false |
| 37 | Definitely, Maybe | - | - | - | $2,469 | 15 | $192,508 | Mar 27 | - | false |
| 38 | Pan's Labyrinth | - | - | - | $782 | 12 | $36,162 | Apr 17 | - | false |
| 39 | 10,000 BC | - | - | - | $745 | 23 | $1,355,277 | Mar 13 | - | false |
