| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Spider-Man 3 | - | - | - | $2,567,647 | 109 | $3,017,668 | May 4 | - | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $1,029,145 | 127 | $3,336,141 | May 25 | - | false |
| 3 | 13 segundos | - | - | - | $585,295 | 30 | $1,404,294 | Apr 20 | - | false |
| 4 | The Reaping | - | - | - | $536,630 | 52 | $1,078,410 | Apr 20 | - | false |
| 5 | Wild Hogs | - | - | - | $503,721 | 32 | $1,020,589 | Apr 20 | - | false |
| 6 | Epic Movie | - | - | - | $433,104 | 31 | $571,252 | May 11 | - | false |
| 7 | Mr. Bean's Holiday | - | - | - | $262,410 | 76 | $576,332 | May 18 | - | false |
| 8 | Pathfinder | - | - | - | $251,996 | 30 | $347,466 | Apr 27 | - | false |
| 9 | A Virgin Grandmother | - | - | - | $225,050 | 16 | $1,256,116 | Mar 2 | - | false |
| 10 | Perfume: The Story of a Murderer | - | - | - | $189,891 | 20 | $393,168 | May 11 | - | false |
| 11 | Cry Wolf | - | - | - | $150,255 | 24 | $252,430 | May 18 | - | false |
| 12 | Primeval | - | - | - | $129,437 | 16 | $171,824 | Apr 27 | - | false |
| 13 | Meet the Robinsons | - | - | - | $111,322 | 59 | $1,717,847 | Mar 30 | - | false |
| 14 | Shooter | - | - | - | $100,244 | 35 | $499,567 | Apr 13 | - | false |
| 15 | Keeping Mum | - | - | - | $93,304 | 12 | $105,447 | May 4 | - | false |
| 16 | Curse of the Golden Flower | - | - | - | $76,096 | 12 | $119,677 | Apr 27 | - | false |
| 17 | Apocalypto | - | - | - | $63,763 | 39 | $431,981 | Apr 13 | - | false |
| 18 | TMNT | - | - | - | $63,268 | 40 | $1,020,916 | Mar 30 | - | false |
| 19 | Cake | - | - | - | $51,311 | 10 | $95,225 | May 11 | - | false |
| 20 | Step Up | - | - | - | $48,592 | 15 | $127,526 | Apr 20 | - | false |
| 21 | Five Times Two | - | - | - | $33,164 | 2 | $44,056 | Apr 27 | - | false |
| 22 | 300 | - | - | - | $29,203 | 65 | $2,030,133 | Mar 23 | - | false |
| 23 | Lucky Number Slevin | - | - | - | $28,326 | 14 | $509,187 | Mar 2 | - | false |
| 24 | Ghost Rider | - | - | - | $26,446 | 63 | $1,204,696 | Mar 30 | - | false |
| 25 | Manual of Love 2 | - | - | - | $8,401 | 7 | $182,188 | Mar 16 | - | false |
| 26 | The Pursuit of Happyness | - | - | - | $5,200 | 9 | $1,268,108 | Feb 9 | - | false |
