| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Spider-Man 3 | - | - | - | $3,859,641 | 326 | $6,053,014 | May 1 | - | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $2,217,627 | 204 | $4,463,110 | May 23 | - | false |
| 3 | Next | - | - | - | $735,168 | 64 | $743,793 | May 10 | - | false |
| 4 | 28 Weeks Later | - | - | - | $327,560 | 61 | $401,676 | May 17 | - | false |
| 5 | Me... Myself | - | - | - | $250,990 | 57 | $1,043,070 | Apr 19 | - | false |
| 6 | Epic Movie | - | - | - | $213,563 | 35 | $218,867 | May 10 | - | false |
| 7 | Train of the Dead | - | - | - | $180,797 | 44 | $180,797 | May 10 | - | false |
| 8 | Wild Hogs | - | - | - | $103,788 | 26 | $104,062 | May 10 | - | false |
| 9 | Pathfinder | - | - | - | $89,264 | 52 | $245,259 | Apr 26 | - | false |
| 10 | Bus Lane | - | - | - | $84,721 | 89 | $2,508,776 | Apr 12 | - | false |
| 11 | Shooter | - | - | - | $81,975 | 66 | $628,021 | Apr 19 | - | false |
| 12 | Protégé | - | - | - | $77,414 | 30 | $77,414 | May 10 | - | false |
| 13 | The Last Mimzy | - | - | - | $72,562 | 31 | $73,355 | May 17 | - | false |
| 14 | Death Water | - | - | - | $62,742 | 30 | $62,853 | May 17 | - | false |
| 15 | Now and Forever | - | - | - | $36,954 | 9 | $36,954 | May 10 | - | false |
| 16 | The Haunted Drum | - | - | - | $32,959 | 45 | $426,623 | Apr 19 | - | false |
| 17 | Blood and Chocolate | - | - | - | $25,946 | 24 | $93,004 | Apr 26 | - | false |
| 18 | Hannibal Rising | - | - | - | $25,391 | 38 | $288,738 | Apr 19 | - | false |
| 19 | Miss Potter | - | - | - | $23,393 | 19 | $47,097 | Apr 26 | - | false |
| 20 | Ma-Mha See Kha Krab | - | - | - | $9,944 | 63 | $1,759,455 | Apr 5 | - | false |
| 21 | Pan's Labyrinth | - | - | - | $4,169 | 12 | $86,203 | Apr 12 | - | false |
| 22 | Meet the Robinsons | - | - | - | $1,242 | 32 | $84,026 | Apr 19 | - | false |
| 23 | Feast | - | - | - | $758 | 5 | $3,610 | Apr 26 | - | false |
| 24 | One Missed Call 3: Final | - | - | - | $695 | 1 | $695 | May 24 | - | false |
| 25 | The Fountain | - | - | - | $415 | 1 | $22,420 | Mar 29 | - | false |
