| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: At World's End | - | - | - | $4,699,643 | 181 | $13,770,170 | May 23 | Buena Vista International | false |
| 2 | Spider-Man 3 | - | - | - | $3,346,599 | 111 | $4,275,875 | May 1 | Sony Pictures Releasing | false |
| 3 | Mr. Bean's Holiday | - | - | - | $1,679,966 | 106 | $6,675,006 | Mar 29 | Universal Pictures International (UPI) | false |
| 4 | Next | - | - | - | $831,263 | 76 | $1,106,344 | Apr 26 | RCV Film Distribution | false |
| 5 | Fracture | - | - | - | $601,857 | 51 | $1,087,745 | May 17 | RCV Film Distribution | false |
| 6 | Wild Hogs | - | - | - | $553,622 | 74 | $1,333,102 | Apr 12 | Buena Vista International | false |
| 7 | The Reef | - | - | - | $457,285 | 85 | $922,690 | May 16 | Independent Films | false |
| 8 | Epic Movie | - | - | - | $456,397 | 50 | $613,127 | Apr 26 | 20th Century Fox International | false |
| 9 | Pan's Labyrinth | - | - | - | $444,368 | 21 | $721,198 | Apr 26 | Paradiso Entertainment | false |
| 10 | The Reaping | - | - | - | $431,820 | 31 | $514,753 | May 10 | Warner Bros. | false |
| 11 | Perfect Stranger | - | - | - | $387,191 | 36 | $790,911 | Apr 12 | Sony Pictures Releasing | false |
| 12 | The Lives of Others | - | - | - | $366,848 | 36 | $2,793,412 | Mar 1 | Cinemien | false |
| 13 | Happily N'Ever After | - | - | - | $338,411 | 67 | $447,140 | Apr 26 | Independent Films | false |
| 14 | The Number 23 | - | - | - | $291,364 | 25 | $477,170 | May 17 | Paradiso Entertainment | false |
| 15 | Shooter | - | - | - | $268,051 | 50 | $785,303 | Apr 12 | Universal Pictures International (UPI) | false |
| 16 | TMNT | - | - | - | $246,044 | 80 | $361,626 | Apr 19 | Warner Bros. | false |
| 17 | Blades of Glory | - | - | - | $197,277 | 36 | $247,412 | May 10 | Universal Pictures International (UPI) | false |
| 18 | Bridge to Terabithia | - | - | - | $182,693 | 66 | $208,517 | Apr 26 | RCV Film Distribution | false |
| 19 | Dark Blue Almost Black | - | - | - | $63,335 | 8 | $234,327 | May 17 | A-Film Distribution | false |
| 20 | Hot Fuzz | - | - | - | $62,972 | 49 | $630,779 | Apr 5 | Universal Pictures International (UPI) | false |
| 21 | La Vie En Rose | - | - | - | $57,328 | 30 | $693,645 | Mar 8 | RCV Film Distribution | false |
| 22 | Interview | - | - | - | $53,820 | 10 | $55,709 | May 10 | A-Film Distribution | false |
| 23 | Sunshine | - | - | - | $47,060 | 48 | $218,767 | Apr 19 | 20th Century Fox International | false |
| 24 | The Hoax | - | - | - | $39,883 | 15 | $106,712 | May 24 | Independent Films | false |
| 25 | 300 | - | - | - | $37,789 | 76 | $2,543,531 | Mar 22 | Warner Bros. | false |
| 26 | The Namesake | - | - | - | $33,447 | 6 | $49,005 | May 10 | 20th Century Fox International | false |
| 27 | It's a Boy Girl Thing | - | - | - | $27,810 | 20 | $261,818 | Apr 5 | RCV Film Distribution | false |
| 28 | Captain Alatriste: The Spanish Musketeer | - | - | - | $15,936 | 10 | $21,098 | May 10 | RCV Film Distribution | false |
| 29 | Music and Lyrics | - | - | - | $14,336 | 96 | $2,344,853 | Mar 8 | Warner Bros. | false |
| 30 | Barnyard | - | - | - | $14,015 | 74 | $1,161,390 | Feb 15 | Universal Pictures International (UPI) | false |
| 31 | The Dead Girl | - | - | - | $12,127 | 7 | $23,744 | May 24 | RCV Film Distribution | false |
| 32 | Golden Door | - | - | - | $11,802 | 7 | $28,396 | May 24 | A-Film Distribution | false |
| 33 | Norbit | - | - | - | $10,207 | 84 | $2,091,061 | Mar 15 | Universal Pictures International (UPI) | false |
| 34 | The Boss of It All | - | - | - | $6,716 | 5 | $6,716 | May 3 | A-Film Distribution | false |
| 35 | The Fountain | - | - | - | $3,902 | 5 | $25,518 | May 3 | 20th Century Fox International | false |
| 36 | Tough Enough | - | - | - | $2,267 | 4 | $2,267 | May 24 | Benelux Film Distributors | false |
| 37 | Close to Home | - | - | - | $2,242 | 6 | $2,242 | May 16 | Cinemien | false |
| 38 | Dry Season | - | - | - | $680 | 2 | $680 | May 17 | A-Film Distribution | false |
