| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Spider-Man 3 | - | - | - | $22,742,189 | 916 | $26,340,543 | May 4 | Sony Pictures Releasing | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $10,068,283 | 909 | $22,456,358 | May 23 | Buena Vista International | false |
| 3 | My Brother is an Only Child | - | - | - | $3,245,638 | 482 | $9,406,247 | Apr 20 | Warner Bros. | false |
| 4 | Epic Movie | - | - | - | $2,618,494 | 247 | $4,270,127 | Apr 27 | 20th Century Fox International | false |
| 5 | The Number 23 | - | - | - | $2,322,098 | 258 | $4,079,576 | Apr 23 | 01 Distribution | false |
| 6 | Zodiac | - | - | - | $2,118,135 | 230 | $3,349,611 | May 18 | Warner Bros. | false |
| 7 | Man of the Year | - | - | - | $1,669,701 | 256 | $1,858,106 | May 11 | Medusa Distribuzione | false |
| 8 | The Good Shepherd | - | - | - | $1,623,785 | 320 | $4,105,822 | Apr 20 | Medusa Distribuzione | false |
| 9 | The Lives of Others | - | - | - | $1,447,111 | 112 | $5,220,873 | Apr 6 | 01 Distribution | false |
| 10 | Wild Hogs | - | - | - | $1,347,244 | 292 | $4,024,291 | Apr 20 | Buena Vista International | false |
| 11 | La Vie En Rose | - | - | - | $1,086,033 | 162 | $1,458,533 | May 4 | Mikado Film | false |
| 12 | Night Bus | - | - | - | $1,084,700 | 195 | $1,473,810 | May 11 | 01 Distribution | false |
| 13 | Voce del verbo amore | - | - | - | $689,247 | 222 | $1,062,488 | Apr 27 | Medusa Distribuzione | false |
| 14 | Curse of the Golden Flower | - | - | - | $669,087 | 155 | $2,082,430 | May 25 | 01 Distribution | false |
| 15 | The Hills Have Eyes 2 | - | - | - | $611,586 | 159 | $630,079 | May 11 | 20th Century Fox International | false |
| 16 | Four Minutes | - | - | - | $580,035 | 44 | $1,092,673 | May 4 | Lady Film | false |
| 17 | A Dream House Nightmare | - | - | - | $553,306 | 141 | $1,554,077 | Apr 13 | Moviemax | false |
| 18 | Slow Burn | - | - | - | $493,546 | 129 | $493,546 | May 4 | Eagle Pictures | false |
| 19 | Breach | - | - | - | $478,505 | 153 | $555,526 | May 18 | Mikado Film | false |
| 20 | One Hundred Nails | - | - | - | $391,596 | 157 | $3,404,025 | Mar 30 | Mikado Film | false |
| 21 | Prey | - | - | - | $320,284 | 135 | $325,151 | May 18 | Eagle Pictures | false |
| 22 | Mr. Bean's Holiday | - | - | - | $215,361 | 429 | $7,493,771 | Apr 6 | Universal Pictures International (UPI) | false |
| 23 | Perfect Stranger | - | - | - | $209,308 | 285 | $2,273,376 | Apr 13 | Sony Pictures Releasing | false |
| 24 | Sunshine | - | - | - | $197,979 | 238 | $1,123,238 | Apr 20 | 20th Century Fox International | false |
| 25 | Me, the Other | - | - | - | $197,090 | 60 | $233,611 | May 18 | 20th Century Fox International | false |
| 26 | Ghost Son | - | - | - | $184,407 | 80 | $295,024 | May 4 | Moviemax | false |
| 27 | Breakfast on Pluto | - | - | - | $184,029 | 82 | $531,180 | May 25 | Fandango | false |
| 28 | Goya's Ghosts | - | - | - | $178,990 | 200 | $1,199,024 | Apr 13 | Medusa Distribuzione | false |
| 29 | The Lark Farm | - | - | - | $85,670 | 68 | $1,033,304 | Mar 23 | 01 Distribution | false |
| 30 | Salvador | - | - | - | $75,083 | 40 | $120,145 | Apr 27 | Istituto Luce | false |
| 31 | Selon Charlie | - | - | - | $74,754 | 19 | $272,154 | Apr 13 | Lucky Red | false |
| 32 | Could This Be Love? | - | - | - | $74,193 | 42 | $74,193 | May 11 | Buena Vista International | false |
| 33 | Chronicle of an Escape | - | - | - | $70,627 | 17 | $70,627 | May 4 | Fandango | false |
| 34 | Le ferie di Licu | - | - | - | $65,314 | 6 | $142,015 | May 4 | Independent Films | false |
| 35 | 7 km da Gerusalemme | - | - | - | $63,711 | 31 | $113,486 | May 4 | Mediafilm | false |
| 36 | The Illusionist | - | - | - | $60,118 | 309 | $3,211,198 | Apr 6 | Eagle Pictures | false |
| 37 | Shooter | - | - | - | $59,461 | 145 | $513,983 | Apr 20 | Universal Pictures International (UPI) | false |
| 38 | Quatre étoiles | - | - | - | $57,056 | 27 | $60,759 | May 11 | BIM Distribuzione | false |
| 39 | Tutte le donne della mia vita | - | - | - | $56,776 | 243 | $1,084,921 | Apr 13 | Eagle Pictures | false |
| 40 | The Ball | - | - | - | $53,946 | 4 | $306,304 | Mar 30 | Independent Films | false |
| 41 | Climates | - | - | - | $53,913 | 15 | $138,638 | Apr 20 | BIM Distribuzione | false |
| 42 | American Masters: Sketches of Frank Gehry | - | - | - | $53,157 | 9 | $205,170 | Mar 30 | BIM Distribuzione | false |
| 43 | Tales from Earthsea | - | - | - | $46,031 | 34 | $199,415 | Apr 20 | Lucky Red | false |
| 44 | Still Life | - | - | - | $37,940 | 23 | $391,607 | Mar 23 | Lucky Red | false |
| 45 | My Brother's Summer | - | - | - | $37,554 | 7 | $38,405 | May 4 | Independent Films | false |
| 46 | Stay Alive | - | - | - | $28,539 | 162 | $1,411,248 | Mar 30 | Medusa Distribuzione | false |
| 47 | The Wind Blows Round | - | - | - | $24,030 | 15 | $659,151 | May 4 | Aranciafilm | false |
| 48 | Goodbye Bafana | - | - | - | $23,952 | 105 | $546,873 | Mar 30 | Istituto Luce | false |
| 49 | Manslaughter 2007 Re-release | - | - | - | $19,521 | 8 | $76,061 | Apr 13 | Teodora Film | false |
| 50 | Il punto rosso | - | - | - | $18,336 | 9 | $21,273 | May 25 | Independent Films | false |
| 51 | Il 7 e l'8 | - | - | - | $13,921 | 306 | $10,412,376 | Mar 16 | Medusa Distribuzione | false |
| 52 | Flying Lessons | - | - | - | $13,194 | 147 | $2,270,431 | Mar 16 | 01 Distribution | false |
| 53 | The History Boys | - | - | - | $12,170 | 20 | $22,402 | May 25 | 20th Century Fox International | false |
| 54 | The Unknown Woman | - | - | - | $11,434 | 297 | $5,459,456 | Oct 20 | Medusa Distribuzione | false |
| 55 | Last Minute Marocco | - | - | - | $10,615 | 147 | $553,065 | Apr 13 | 01 Distribution | false |
| 56 | Cuando la verdad despierta | - | - | - | $9,683 | 2 | $71,149 | Apr 27 | Independent Films | false |
| 57 | Dry Season | - | - | - | $9,367 | 4 | $16,708 | May 25 | Lucky Red | false |
| 58 | Notes on a Scandal | - | - | - | $7,489 | 94 | $1,983,521 | Feb 23 | 20th Century Fox International | false |
| 59 | Bridge to Terabithia | - | - | - | $7,375 | 315 | $3,249,576 | Mar 30 | Moviemax | false |
| 60 | Il Sorriso dell'ultima notte | - | - | - | $7,367 | 1 | $11,683 | May 18 | Independent Films | false |
| 61 | Fratelli di sangue | - | - | - | $3,640 | 3 | $349,952 | Nov 10 | L'Altrofilm | false |
| 62 | Lights in the Dusk | - | - | - | $3,228 | 27 | $457,035 | Jan 12 | BIM Distribuzione | false |
| 63 | Prey for Rock & Roll | - | - | - | $2,690 | 37 | $28,237 | Jun 4 | Eagle Pictures | false |
| 64 | The Hills Have Eyes | - | - | - | $2,636 | 249 | $1,589,032 | Aug 25 | 20th Century Fox International | false |
| 65 | La vita degli altri | - | - | - | $2,610 | 2 | $37,115 | Apr 22 | Thule | false |
| 66 | Charlotte's Web | - | - | - | $2,565 | 3 | $86,446 | Mar 9 | Universal Pictures International (UPI) | false |
| 67 | The Painted Veil | - | - | - | $2,087 | 65 | $610,692 | Feb 23 | Eagle Pictures | false |
| 68 | Shooting Silvio | - | - | - | $2,029 | 3 | $18,781 | Mar 3 | Independent Films | false |
| 69 | Face Addict | - | - | - | $2,014 | 1 | $11,987 | Nov 15 | Istituto Luce | false |
| 70 | Red Like the Sky | - | - | - | $1,903 | 4 | $194,758 | Mar 30 | Lady Film | false |
| 71 | Molière | - | - | - | $1,860 | 84 | $134,143 | Apr 6 | BIM Distribuzione | false |
| 72 | Maradona, the Hand of God | - | - | - | $1,035 | 115 | $642,321 | Mar 30 | 01 Distribution | false |
| 73 | The Page Turner | - | - | - | $850 | 29 | $497,134 | Feb 9 | Mikado Film | false |
