| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Spider-Man 3 | - | - | - | $2,701,420 | 90 | $2,916,160 | May 3 | Sony Pictures Releasing | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $1,152,492 | 100 | $2,772,756 | May 24 | Buena Vista International | false |
| 3 | Papelucho y el marciano | - | - | - | $146,069 | 33 | $969,819 | May 17 | Bazuca Films | false |
| 4 | The Queen | - | - | - | $136,436 | 9 | $265,563 | Apr 26 | Bazuca Films | false |
| 5 | Hoodwinked! | - | - | - | $126,617 | 20 | $257,026 | Apr 26 | Transeuropa | false |
| 6 | Scoop | - | - | - | $121,682 | 7 | $192,110 | May 10 | CDI Films | false |
| 7 | The Reaping | - | - | - | $113,316 | 31 | $469,168 | Apr 5 | Warner Bros. | false |
| 8 | 300 | - | - | - | $96,476 | 76 | $1,500,771 | Mar 29 | Warner Bros. | false |
| 9 | Pulse | - | - | - | $75,185 | 14 | $173,249 | Apr 19 | Bazuca Films | false |
| 10 | Meet the Robinsons | - | - | - | $71,599 | 39 | $519,115 | Apr 5 | Buena Vista International | false |
| 11 | The Good Shepherd | - | - | - | $60,851 | 6 | $119,694 | Apr 26 | United International Pictures | false |
| 12 | Mr. Bean's Holiday | - | - | - | $59,204 | 25 | $309,265 | Apr 5 | United International Pictures | false |
| 13 | Epic Movie | - | - | - | $58,151 | 14 | $166,404 | Apr 19 | 20th Century Fox International | false |
| 14 | Sunshine | - | - | - | $50,241 | 14 | $115,056 | Apr 26 | 20th Century Fox International | false |
| 15 | Happily N'Ever After | - | - | - | $43,885 | 15 | $144,606 | Apr 19 | Bazuca Films | false |
| 16 | Apocalypto | - | - | - | $24,213 | 23 | $365,537 | Mar 8 | 20th Century Fox International | false |
| 17 | Pathfinder | - | - | - | $21,676 | 18 | $122,882 | Apr 12 | 20th Century Fox International | false |
| 18 | Man About Town | - | - | - | $18,831 | 7 | $19,885 | May 10 | Andes Films | false |
| 19 | TMNT | - | - | - | $16,769 | 26 | $234,670 | Apr 5 | Bazuca Films | false |
| 20 | Music and Lyrics | - | - | - | $12,983 | 27 | $209,768 | Mar 15 | Warner Bros. | false |
| 21 | Ghost Rider | - | - | - | $8,353 | 36 | $268,740 | Apr 5 | Sony Pictures Releasing | false |
| 22 | Hard Candy | - | - | - | $8,079 | 3 | $30,108 | May 17 | Bazuca Films | false |
| 23 | Shooter | - | - | - | $5,178 | 22 | $106,196 | Apr 12 | United International Pictures | false |
| 24 | The Pursuit of Happyness | - | - | - | $2,104 | 11 | $237,232 | Feb 8 | Sony Pictures Releasing | false |
| 25 | Curse of the Golden Flower | - | - | - | $1,547 | 13 | $117,232 | Mar 22 | Sony Pictures Releasing | false |
| 26 | The Road to Guantanamo | - | - | - | $1,321 | 1 | $7,614 | Apr 26 | Transeuropa | false |
| 27 | Pan's Labyrinth | - | - | - | $866 | 10 | $245,640 | Feb 22 | Warner Bros. | false |
| 28 | The Last King of Scotland | - | - | - | $866 | 5 | $106,993 | Feb 15 | 20th Century Fox International | false |
| 29 | Infection 2006 Re-release | - | - | - | $55 | 1 | $42,955 | Mar 1 | Andes Films | false |
