| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Spider-Man 3 | - | - | - | $21,921,822 | 875 | $24,204,031 | May 4 | - | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $6,662,169 | 789 | $15,770,834 | May 25 | - | false |
| 3 | Fracture | - | - | - | $1,633,200 | 87 | $2,582,495 | May 11 | - | false |
| 4 | Mr. Bean's Holiday | - | - | - | $1,131,536 | 140 | $4,190,443 | Apr 6 | - | false |
| 5 | 300 | - | - | - | $1,103,267 | 469 | $11,207,791 | Mar 30 | - | false |
| 6 | Because I Said So | - | - | - | $1,029,201 | 67 | $1,421,246 | Apr 27 | - | false |
| 7 | Meet the Robinsons | - | - | - | $877,211 | 245 | $3,417,394 | Apr 6 | - | false |
| 8 | Wild Hogs | - | - | - | $643,303 | 120 | $1,464,109 | Apr 20 | - | false |
| 9 | Hannibal Rising | - | - | - | $547,317 | 132 | $1,365,244 | Apr 20 | - | false |
| 10 | The Reaping | - | - | - | $328,563 | 140 | $985,982 | Apr 20 | - | false |
| 11 | School for Scoundrels | - | - | - | $302,857 | 84 | $310,922 | May 18 | - | false |
| 12 | TMNT | - | - | - | $283,104 | 245 | $1,130,629 | Apr 13 | - | false |
| 13 | Alpha Dog | - | - | - | $269,136 | 34 | $316,717 | May 18 | - | false |
| 14 | Ó Pai, Ó: Look at This | - | - | - | $251,404 | 101 | $1,519,302 | Mar 30 | - | false |
| 15 | Perfect Stranger | - | - | - | $250,077 | 143 | $2,210,902 | Apr 13 | - | false |
| 16 | Drained | - | - | - | $186,193 | 21 | $786,460 | Mar 23 | - | false |
| 17 | O Mundo Em Duas Voltas | - | - | - | $176,938 | 27 | $221,391 | Apr 27 | - | false |
| 18 | The Number 23 | - | - | - | $175,887 | 75 | $1,461,806 | Mar 23 | - | false |
| 19 | Monica's Gang in an Adventure in Time | - | - | - | $157,213 | 151 | $2,184,716 | Feb 16 | - | false |
| 20 | Caixa Dois | - | - | - | $156,184 | 156 | $1,099,975 | Apr 6 | - | false |
| 21 | Miss Potter | - | - | - | $153,174 | 54 | $253,980 | Apr 27 | - | false |
| 22 | The Secret | - | - | - | $146,394 | 19 | $383,392 | Mar 30 | - | false |
| 23 | Marie Antoinette | - | - | - | $133,898 | 29 | $893,109 | Mar 16 | - | false |
| 24 | The Year My Parents Went on Vacation | - | - | - | $119,679 | 3 | $1,613,004 | Nov 2 | - | false |
| 25 | Bog of Beasts | - | - | - | $101,930 | 10 | $202,099 | May 11 | Imovision | false |
| 26 | Forbidden to Forbid | - | - | - | $88,125 | 13 | $166,288 | Apr 27 | Riofilme | false |
| 27 | Princesses | - | - | - | $87,077 | 19 | $100,903 | May 25 | Independent Films | false |
| 28 | Orchestra Seats | - | - | - | $87,077 | 12 | $546,970 | May 11 | - | false |
| 29 | The Host | - | - | - | $73,045 | 30 | $75,440 | May 18 | - | false |
| 30 | Breaking and Entering | - | - | - | $64,204 | 6 | $148,731 | May 11 | - | false |
| 31 | Primeval | - | - | - | $63,459 | 44 | $105,494 | Apr 27 | - | false |
| 32 | Scoop | - | - | - | $56,690 | 69 | $1,084,524 | Mar 16 | - | false |
| 33 | Baptism of Blood | - | - | - | $56,353 | 22 | $141,418 | Apr 20 | - | false |
| 34 | Ghost Rider | - | - | - | $42,367 | 254 | $7,041,843 | Mar 2 | - | false |
| 35 | The Mad Hatter | - | - | - | $41,258 | 19 | $218,193 | Apr 6 | - | false |
| 36 | The Tiger and the Snow | - | - | - | $39,917 | 14 | $45,964 | May 25 | - | false |
| 37 | Deja Vu | - | - | - | $20,927 | 4 | $2,988,591 | Jan 19 | - | false |
| 38 | Sunshine | - | - | - | $17,739 | 31 | $202,514 | Apr 13 | - | false |
| 39 | The Namesake | - | - | - | $15,936 | 6 | $74,549 | May 25 | - | false |
| 40 | The Knight Didi and the Princess Lili | - | - | - | $15,896 | 14 | $2,602,502 | Dec 22 | - | false |
| 41 | Prey | - | - | - | $14,530 | 54 | $159,638 | Apr 13 | - | false |
| 42 | Hollywoodland | - | - | - | $12,616 | 9 | $59,880 | Mar 9 | - | false |
| 43 | The Pursuit of Happyness | - | - | - | $5,047 | 192 | $6,331,267 | Feb 2 | - | false |
| 44 | Stranger Than Fiction | - | - | - | $1,715 | 4 | $654,919 | Jan 12 | - | false |
