| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Spider-Man 3 | - | - | - | $379,142 | 10 | $400,371 | May 3 | - | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $98,678 | 10 | $238,954 | May 24 | - | false |
| 3 | Epic Movie | - | - | - | $19,841 | 3 | $23,118 | May 10 | - | false |
| 4 | Pathfinder | - | - | - | $15,551 | 6 | $29,733 | Apr 19 | - | false |
| 5 | 300 | - | - | - | $8,151 | 9 | $159,240 | Mar 29 | - | false |
| 6 | Perfect Stranger | - | - | - | $4,986 | 4 | $21,140 | Apr 19 | - | false |
| 7 | Charlotte's Web | - | - | - | $4,490 | 3 | $4,490 | May 17 | - | false |
| 8 | Meet the Robinsons | - | - | - | $4,457 | 6 | $55,167 | Apr 5 | - | false |
| 9 | Miami Vice | - | - | - | $4,325 | 2 | $4,325 | May 10 | - | false |
| 10 | Curse of the Golden Flower | - | - | - | $4,169 | 5 | $8,992 | Apr 26 | - | false |
| 11 | Cocalero | - | - | - | $3,259 | 3 | $8,563 | Apr 26 | - | false |
| 12 | Little Children | - | - | - | $3,113 | 2 | $3,113 | May 3 | - | false |
| 13 | Little Miss Sunshine | - | - | - | $2,422 | 2 | $5,024 | Apr 26 | - | false |
| 14 | Keeping Mum | - | - | - | $2,156 | 2 | $2,156 | May 17 | - | false |
