| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Da Vinci Code | - | - | - | $25,289,806 | 910 | $39,197,477 | May 19 | Sony Pictures Releasing | false |
| 2 | Ice Age 2: The Meltdown | - | - | - | $8,078,278 | 544 | $25,985,050 | Apr 21 | 20th Century Fox International | false |
| 3 | Mission: Impossible III | - | - | - | $7,185,317 | 621 | $7,636,309 | May 5 | United International Pictures | false |
| 4 | Volver | - | - | - | $4,167,033 | 309 | $8,641,208 | May 19 | Warner Bros. | false |
| 5 | Take the Lead | - | - | - | $3,695,499 | 351 | $5,672,559 | Apr 28 | Eagle Pictures | false |
| 6 | X-Men: The Last Stand | - | - | - | $3,427,089 | 463 | $7,401,192 | May 26 | 20th Century Fox International | false |
| 7 | Scary Movie 4 | - | - | - | $1,913,230 | 408 | $9,487,282 | Apr 21 | Buena Vista International | false |
| 8 | Romance & Cigarettes | - | - | - | $1,343,818 | 114 | $1,455,348 | May 5 | Nexo | false |
| 9 | Inside Man | - | - | - | $1,264,526 | 301 | $9,116,281 | Apr 7 | United International Pictures | false |
| 10 | The Devil's Rejects | - | - | - | $1,101,520 | 232 | $1,101,520 | May 12 | Eagle Pictures | false |
| 11 | The Valet | - | - | - | $988,746 | 186 | $86,983 | May 12 | Medusa Distribuzione | false |
| 12 | The Wedding Director | - | - | - | $855,349 | 209 | $2,468,448 | Apr 21 | 01 Distribution | false |
| 13 | Libero (Along the Ridge) | - | - | - | $790,501 | 74 | $975,349 | May 5 | 01 Distribution | false |
| 14 | Firewall | - | - | - | $756,345 | 168 | $1,438,493 | Apr 28 | Warner Bros. | false |
| 15 | One Last Dance 2006 Re-release | - | - | - | $651,804 | 219 | $1,041,160 | May 26 | Eagle Pictures | false |
| 16 | Two for the Money | - | - | - | $589,571 | 150 | $1,123,368 | Apr 28 | United International Pictures | false |
| 17 | Ask the Dust | - | - | - | $472,626 | 140 | $844,879 | Apr 28 | Moviemax | false |
| 18 | Il mio miglior nemico | - | - | - | $323,919 | 561 | $23,500,977 | Mar 10 | Filmauro | false |
| 19 | The Caiman | - | - | - | $315,609 | 386 | $8,571,161 | Mar 24 | Sacher Distribuzione | false |
| 20 | In ascolto | - | - | - | $251,744 | 143 | $362,742 | Apr 28 | Medusa Distribuzione | false |
| 21 | Into Great Silence | - | - | - | $241,986 | 47 | $897,895 | Mar 31 | Metacinema | false |
| 22 | Atomised | - | - | - | $217,587 | 44 | $514,310 | Apr 21 | Lucky Red | false |
| 23 | Big Momma's House 2 | - | - | - | $208,039 | 99 | $236,634 | May 12 | 20th Century Fox International | false |
| 24 | Yours, Mine & Ours | - | - | - | $193,004 | 79 | $193,004 | May 5 | Sony Pictures Releasing | false |
| 25 | 4-4-2 - Il gioco più bello del mondo | - | - | - | $152,504 | 101 | $452,097 | May 19 | Medusa Distribuzione | false |
| 26 | Notte prima degli esami | - | - | - | $119,553 | 327 | $15,905,030 | Feb 17 | 01 Distribution | false |
| 27 | Bubble | - | - | - | $111,913 | 29 | $111,913 | May 12 | Mediafilm | false |
| 28 | Ti lascio perché ti amo troppo | - | - | - | $108,201 | 47 | $930,096 | Apr 14 | Mikado Film | false |
| 29 | Midsummer Dream | - | - | - | $59,699 | 110 | $149,675 | May 26 | Medusa Distribuzione | false |
| 30 | Three Days of Anarchy | - | - | - | $40,883 | 81 | $40,883 | May 12 | Thule | false |
| 31 | Mission: Impossible 2006 Re-release | - | - | - | $34,807 | 10 | $34,807 | May 5 | United International Pictures | false |
| 32 | The Cave of the Yellow Dog | - | - | - | $13,917 | 14 | $162,267 | Apr 28 | BIM Distribuzione | false |
| 33 | Whisky | - | - | - | $13,185 | 10 | $13,185 | May 26 | Kitchen | false |
