| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Da Vinci Code | - | - | - | $43,165,356 | 523 | $55,532,575 | May 19 | Sony Pictures Releasing | false |
| 2 | Mission: Impossible III | - | - | - | $27,569,447 | 512 | $29,032,559 | May 4 | United International Pictures | false |
| 3 | X-Men: The Last Stand | - | - | - | $22,364,930 | 470 | $35,645,846 | May 26 | 20th Century Fox International | false |
| 4 | The Wild | - | - | - | $5,086,470 | 439 | $7,905,493 | May 26 | Buena Vista International | false |
| 5 | Prime | - | - | - | $4,847,115 | 383 | $5,203,312 | May 12 | Momentum Pictures | false |
| 6 | Confetti | - | - | - | $3,812,335 | 300 | $3,908,918 | May 5 | 20th Century Fox International | false |
| 7 | 16 Blocks | - | - | - | $2,826,353 | 302 | $4,251,554 | Apr 28 | Warner Bros. | false |
| 8 | Silent Hill | - | - | - | $2,768,229 | 308 | $6,734,879 | Apr 21 | Pathé | false |
| 9 | When a Stranger Calls | - | - | - | $2,385,590 | 304 | $2,400,135 | May 12 | Sony Pictures Releasing | false |
| 10 | Curious George | - | - | - | $1,763,827 | 319 | $2,763,105 | May 26 | United International Pictures | false |
| 11 | Scary Movie 4 | - | - | - | $1,691,078 | 409 | $11,037,123 | Apr 14 | Buena Vista International | false |
| 12 | She's the Man | - | - | - | $1,351,430 | 306 | $8,673,300 | Apr 7 | Entertainment Film Distributors | false |
| 13 | Slither | - | - | - | $1,288,496 | 321 | $2,179,983 | Apr 28 | Entertainment Film Distributors | false |
| 14 | Waiting... | - | - | - | $1,160,297 | 238 | $1,171,170 | May 19 | Momentum Pictures | false |
| 15 | Fanaa | - | - | - | $1,113,027 | 39 | $2,183,369 | May 26 | Yash Raj Films | false |
| 16 | Brick | - | - | - | $1,038,472 | 49 | $1,330,381 | May 12 | Optimum Releasing | false |
| 17 | Eight Below | - | - | - | $732,700 | 397 | $2,102,130 | Apr 21 | Buena Vista International | false |
| 18 | Take the Lead | - | - | - | $640,271 | 301 | $4,240,032 | Apr 7 | Entertainment Film Distributors | false |
| 19 | The Shaggy Dog | - | - | - | $585,846 | 430 | $5,534,468 | Mar 31 | Buena Vista International | false |
| 20 | 36 China Town | - | - | - | $569,467 | 34 | $581,202 | May 5 | Tip Top Entertainment (TTE) | false |
| 21 | An American Haunting | - | - | - | $447,778 | 269 | $3,394,905 | Apr 14 | Lionsgate | false |
| 22 | The Squid and the Whale | - | - | - | $433,737 | 24 | $1,229,887 | Apr 7 | Sony Pictures Releasing | false |
| 23 | Friends with Money | - | - | - | $357,887 | 51 | $889,902 | May 26 | Sony Pictures Releasing | false |
| 24 | Syriana | - | - | - | $282,452 | 236 | $7,162,144 | Mar 3 | Warner Bros. | false |
| 25 | Yours, Mine & Ours | - | - | - | $210,825 | 265 | $2,369,263 | Mar 31 | Sony Pictures Releasing | false |
| 26 | V for Vendetta | - | - | - | $203,323 | 410 | $20,863 | Oct 30 | Warner Bros. | false |
| 27 | The Thief Lord | - | - | - | $200,952 | 140 | $227,056 | May 26 | Warner Bros. | false |
| 28 | Tristan + Isolde | - | - | - | $188,841 | 245 | $1,108,254 | Apr 21 | 20th Century Fox International | false |
| 29 | Enron: The Smartest Guys in the Room | - | - | - | $169,004 | 25 | $303,736 | Apr 28 | Lionsgate | false |
| 30 | The King | - | - | - | $161,268 | 29 | $198,419 | May 19 | Tartan | false |
| 31 | Transamerica | - | - | - | $158,246 | 42 | $1,392,753 | Mar 24 | Pathé | false |
| 32 | Down in the Valley | - | - | - | $137,080 | 21 | $210,507 | May 26 | Icon Film Distribution Australia | false |
| 33 | Time to Leave | - | - | - | $134,587 | 41 | $156,439 | May 12 | Artificial Eye | false |
| 34 | The Mistress of Spices | - | - | - | $133,849 | 56 | $465,948 | Apr 21 | Entertainment Film Distributors | false |
| 35 | Humko Deewana Kar Gaye | - | - | - | $131,250 | 38 | $899,334 | Apr 14 | UTV Motion Pictures | false |
| 36 | Deep Sea | - | - | - | $129,236 | 3 | $2,869,929 | Mar 3 | IMAX | false |
| 37 | Junebug | - | - | - | $124,731 | 20 | $399,619 | Apr 14 | Miracle Films | false |
| 38 | Ballets Russes | - | - | - | $113,468 | 20 | $261,752 | Apr 21 | Revolver Entertainment | false |
| 39 | Tsotsi | - | - | - | $111,797 | 87 | $1,442,451 | Mar 17 | Momentum Pictures | false |
| 40 | Hostel | - | - | - | $105,194 | 304 | $7,736,178 | Mar 24 | Sony Pictures Releasing | false |
| 41 | The Three Burials of Melquiades Estrada | - | - | - | $99,736 | 29 | $720,843 | Mar 31 | Optimum Releasing | false |
| 42 | Alien Autopsy | - | - | - | $90,722 | 417 | $4,009,720 | Apr 7 | Warner Bros. | false |
| 43 | The Devil and Daniel Johnston | - | - | - | $87,184 | 10 | $97,889 | May 5 | Tartan | false |
| 44 | Paradise Now | - | - | - | $82,434 | 14 | $257,795 | Apr 14 | Warner Bros. | false |
| 45 | Love + Hate | - | - | - | $79,934 | 44 | $79,934 | May 5 | Verve Pictures | false |
| 46 | Pierrepoint: The Last Hangman | - | - | - | $73,254 | 18 | $429,706 | Apr 7 | Lionsgate | false |
| 47 | Freedomland | - | - | - | $68,216 | 78 | $130,490 | Apr 28 | Sony Pictures Releasing | false |
| 48 | Fateless | - | - | - | $63,933 | 5 | $76,285 | May 5 | - | false |
| 49 | C.R.A.Z.Y. | - | - | - | $63,028 | 28 | $175,862 | Apr 21 | Soda Pictures | false |
| 50 | U-Carmen eKhayelitsha | - | - | - | $61,900 | 9 | $115,141 | Apr 21 | Tartan | false |
| 51 | Once in a Lifetime: The Extraordinary Story of the New York Cosmos | - | - | - | $55,151 | 22 | $67,197 | May 19 | Pathé | false |
| 52 | The White Countess | - | - | - | $54,233 | 57 | $540,512 | Mar 31 | Sony Pictures Releasing | false |
| 53 | The Little Polar Bear 2: The Mysterious Island | - | - | - | $50,865 | 226 | $1,003,680 | Feb 10 | Warner Bros. | false |
| 54 | Darna Zaroori Hai | - | - | - | $47,234 | 19 | $104,314 | Apr 28 | Tip Top Entertainment (TTE) | false |
| 55 | Shooting Dogs 2006 Re-release | - | - | - | $45,360 | 20 | $286,065 | Mar 31 | Metrodome Distribution | false |
| 56 | Tom, Dick, and Harry | - | - | - | $42,204 | 8 | $42,204 | May 12 | Venus | false |
| 57 | Romance & Cigarettes | - | - | - | $40,091 | 29 | $439,112 | Mar 24 | Icon Film Distribution Australia | false |
| 58 | Caché | - | - | - | $31,673 | 40 | $2,667,906 | Jan 27 | Artificial Eye | false |
| 59 | Wal-Mart: The High Cost of Low Price | - | - | - | $29,255 | 6 | $47,197 | May 12 | Tartan | false |
| 60 | Good Night, and Good Luck. | - | - | - | $27,943 | 139 | $4,400,071 | Feb 19 | Redbus Film Distribution | false |
| 61 | Tathastu | - | - | - | $21,374 | 17 | $21,374 | May 12 | Spark Worldwide | false |
| 62 | The Magician | - | - | - | $18,218 | 18 | $18,218 | May 5 | Miracle Films | false |
| 63 | Quo Vadis, Baby? | - | - | - | $11,454 | 6 | $34,451 | May 12 | Yume Pictures | false |
| 64 | Ankahee | - | - | - | $11,062 | 4 | $11,062 | May 19 | Venus | false |
| 65 | Initial D | - | - | - | $8,090 | 15 | $8,090 | May 12 | Contender Entertainment Group | false |
| 66 | The World's Fastest Indian | - | - | - | $7,219 | 78 | $840,237 | Mar 10 | Icon Film Distribution Australia | false |
| 67 | Kidulthood | - | - | - | $7,062 | 42 | $849,650 | Mar 3 | Revolver Entertainment | false |
| 68 | Pudhu Pettai | - | - | - | $4,652 | 2 | $4,652 | May 26 | Ayngaran International | false |
